IndraLab

Statements

Modified PTEN leads to the phosphorylation of AKT. 20 / 20
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"Dominant negative Akt prevents IGF-I mediated survival in Schwann cells, and PTEN overexpression, which decreases Akt phosphorylation, enhances mannitol induced NBL cell apoptosis."
19259821
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"In these experiments, expression of PTEN C124S or PTEN G129E had no detectable effect on Akt phosphorylation, whereas expression of either wild-type PTEN or PTEN Y138L at approximately physiological levels greatly reduced the phosphorylation of Akt."
19915616
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
19384426
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"Di-Poi et al. suggested that PPARbeta and delta activation increases the expression of 3-phosphoinositide-dependent-protein kinae 1 (PDPK1) and integrin linked kinase (ILK), and decreases the expression of PTEN, causing increased phosphorylation of AKT, leading to antiapoptotic signaling and enhanced cell survival [XREF_BIBR]."
23024650
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"Thus, the signaling pathway by which TGFbeta and ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation."
20147383
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"We previously demonstrated that Morgana binds to and inhibits ROCK I and II XREF_BIBR, XREF_BIBR and that through ROCK I inhibition Morgana downregulates PTEN expression levels thus enhancing AKT phosphorylation 14."
29158506
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"The downregulation of PTEN expression increased Akt phosphorylation, but did not increase that of ERK 1/2."
24155249
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"Transfection of miR-371b-5p mimic into hiPSC-ATIICs leads to significantly decreased expression of endogenous PTEN, which stimulates phosphorylation of Akt and its downstream substrates, GSK3beta and FOXOs, promoting cell proliferation."
28595637
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"PPARgamma and PTEN expression were increased and phosphorylated AKT was present at relatively low expression levels in rosiglitazone treated ovaries."
32354153
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
19384426
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"We observed that miR-429 attenuated PTEN expression induced the phosphorylation of AKT and inhibited the activity of GSK-3beta."
25931210
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"In the present study, however, although down-regulation of PTEN expression increased Akt and GSK3beta phosphorylation -- the downstream effectors of PI (3,4,5) P 3 signaling -- its down-regulation exacerbated glucose uptake (due to activation of ERK) under neuronal insulin resistance."
22875989
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"On the other hand, PTEN overexpression blunts the ability of MAF1 shRNA to promote phosphorylation of AKT, mTOR, and S6 (Supporting Fig."
26910647
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
9778245
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"The mathematical model calibrated based on these data nevertheless predicted that overexpression of SHIP1 or PTEN would decrease AKT phosphorylation even further in these cells."
28123004
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"One promising molecular target is the PI3K/PTEN/AKT/mTOR pathway, a mediator of cell survival and invasion signaling pathways which is often activated in gliomas through either loss of the tumor suppressor PTEN or growth factor mediated AKT phosphorylation (reviewed in Hambardzumyan et al., 2008)."
21827414
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"A series of in vivo and in vitro studies demonstrated that with aging endothelial PTEN levels increase, thereby promoting a decrease in Akt kinase activity, NOS3 phosphorylation and NO production."
23144940
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"We found that the decrease of cellular miR-21, significantly up-regulated the expression of PTEN modulating the phosphorylation of AKT."
26116834
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"In this context, loss of PTEN expression which can potentiate feedback Akt phosphorylation in response to rapamycin is actually a marker of rapalog resistance rather than a biomarker for the use of mTORC1 inhibitors in human bladder cancer cells."
25323681
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
9778245