IndraLab

Statements

Mutated PTEN leads to the phosphorylation of AKT. 7 / 7
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"In their study, Pten mutation alone led to enhanced Akt phosphorylation and lipid aggradation in hepatocytes."
27994508
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"While both PKB and Akt and GSK3 phosphorylation was inhibited by p110beta inhibitors in PTEN mutant cell lines, S6 phosphorylation remained unchanged (XREF_FIG)."
18498248
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"It has been reported that PTEN mutation could promote phosphorylation of Akt in the context of PIK3CA mutation, and in turn provide additive effect on the activation of PI3K pathway."
27899621
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"While both PKB and Akt and GSK3 phosphorylation was inhibited by p110beta inhibitors in PTEN mutant cell lines, S6 phosphorylation remained unchanged (XREF_FIG)."
18498248
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"However, the mutated PTEN-cell line EN-1078D express weak levels of phospho-Akt (data not shown) which suggests that the simple mutation of PTEN in this cell line is not sufficient to induce constitutive Akt phosphorylation."
17894888
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"These results suggest that PIK3CA and PTEN mutations more effectively activate AKT kinase activity and phosphorylation of select AKT downstream targets in cervical tumors when the patient is non obese."
29423104
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"In ovaries, PTEN mutation leaded to over-phosphorylation of AKT."
29409506