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PTEN phosphorylates AKT on S473. 16 / 18
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"Many studies have testified that PTEN was a direct target of miR-21, and levels of PTEN protein modulate Akt phosphorylation on serine 473 ( Carnero et al., 2008; Ma et al., 2011 )."
22130252
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"PTEN upregulation impaired Akt recruitment to the plasma membrane and suppressed Akt phosphorylation at Ser473, thereby inhibiting Akt/GSK3beta/beta-catenin signaling and the expression of COL1 and OCN in BMSCs in vitro and in vivo."
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"As expected, PTEN deficiency led to constitutive phosphorylation of AKT (S473) and, to a lesser degree, 4EBP1 under serum-deprived conditions ( Figures S7 A and S7B)."
32049014
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"In stimulated macrophages, PTEN oxidation led to the temporary inhibition of its phosphatase activity and in the phosphorylation of Akt on Serine 473."
19369943
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"The data in XREF_FIG and XREF_SUPPLEMENTARY (repeat experiments) also show that the extent of Akt S473 phosphorylation induced in the cells upon rescue by P110 * or Pten ablation is moderate and closer to that seen in resting mature B cells than B cells activated by BCR engagement or even just exposed to serum containing culture medium."
19879843
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"Pten deficiency induced increased phosphorylation of Akt at Ser473."
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"PTEN deficiency also was associated with robust phosphorylation of Akt S473; however, this effect did not reflect mTORC2 activation but instead, activation of alternative PDK2s."
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"Immunohistochemical staining of dorsolateral prostate lobes indicated that deletion of Sox4 reduced the PTEN loss-induced phosphorylation of AKT at serine 473 ( xref )."
26701805
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"To verify the proposed signaling mechanisms for spiral ganglion defects in Pax2 Cre/+; Pten loxP and loxP mice, we examined whether Pten deficiency (XREF_SUPPLEMENTARY) upregulates Ser473 phosphorylation of Akt and triggers Ser9 phosphorylation of GSK3beta (pGSK3beta) in the PI3K signaling cascade."
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"Downregulation of PTEN increases phosphorylation of Akt at Ser473, activating a pathway that leads to increased cell migration."
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"Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells."
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"Apart from acting as tumour suppressor, PTEN can negatively regulate the activity of AKT through its lipid phosphatase function by dephosphorylating AKT at Ser473 [XREF_BIBR]."
22035408
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"Ectopic expression of miR-144 or PTEN shRNA allowed cells to overcome the inhibition of Akt phosphorylation at Ser 473, cyclin A expression, and p-CDK2 (Thr 39) phosphorylation by TPL but suppressed t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31059711
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"AGK induced PTEN phosphorylation and inactivation, which was associated with enhanced phosphorylation of AKT at both Thr308 and Ser473, and FOXO1 at Thr24, a known target of AKT in both SU-DHL4 (Figure 3G-H) and TMD8 cells (Figure S3B-C)."
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"As expected, Pten -/- mice had increased AKT S473 phosphorylation, a signature activity of mTORC2 activity in mature thymocytes (XREF_FIG)."
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"Here, we report that Pten (-/-) mouse blood contains 25% more platelets than Pten (+/+) blood and that PTEN deficiency significantly shortened the bleeding time, increased the sensitivity of platelets to collagen induced activation and aggregation, and enhanced phosphorylation of Akt at Ser473 in response to collagen."
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