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PTEN leads to the phosphorylation of AKT on T308. 5 / 5
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"As expected, WT PTEN and PTEN Y138L, but not PTEN C124S and PTEN G129E mutants, inhibited AKT T308 phosphorylation ( Figure S1 A)."
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"However, a recent report by Rodrik-Outmezguine et al. showed that phosphorylation of AKT at the Thr308 site and of the AKT substrates including PRAS40, GSK-3beta and FOXO1/3 are only transiently repressed by mTORKIs in PIK3CA mutant (MCF7, BT474) and PTEN deficient (MDA-MB-468) breast cancer cell lines [XREF_BIBR]."
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"As expected, infection of Pten loxP and loxP MEFs with Adeno-Cre reduces PTEN expression, and elevates both Akt S473 and Akt T308 phosphorylation in serum deprived cells [XREF_FIG, lanes 1 & 3] and in insulin stimulated cells [XREF_FIG, lanes 2 & 4]."
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"AGK induced PTEN phosphorylation and inactivation, which was associated with enhanced phosphorylation of AKT at both Thr308 and Ser473, and FOXO1 at Thr24, a known target of AKT in both SU-DHL4 (Figure 3G-H) and TMD8 cells (Figure S3B-C)."
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"PTEN then acts to inhibits PI3K activity and thus block phosphorylation of Akt on its other activating site, at Thr308."
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