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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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KRAS increases the amount of KRAS. 8 / 38
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"Kras G12D/+ mice were treated with AdCre to initiate expression of oncogenic Kras."
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"23 However, the KRAS variant is associated with a BRCA1 mutation like gene expression signature, supporting the notion that there might be increased oncogenic risk in the presence of the KRAS variant and high KRAS expression and low BRCA1 expression, either through mutation or other mechanisms."
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"In addition, Morpholino knocked-down zebrafish embryos of kras caused heart and craniofacial malformations, and expression of mutated kras resulted in maldevelopment of the heart."
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"LCS6 in the KRAS 3 '-UTR mRNA causes an increase in expression of KRAS in vitro and a reduction in let-7 levels in vivo (Chin et al., 2008)."
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"KRAS siRNA effectively reduced KRAS expression, resulting in marked inhibition of p-ERK (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Western blot analysis confirmed that KRAS transfection increased KRAS expression in silibinin treated cells."
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"Western blotting revealed that the expression of KRAS and beta-catenin was eliminated by DDX3 or KRAS silencing, but KRAS expression was unchanged by LY294002, shDDX3 plus KRAS or shDDX3, LY294002 plus KRAS treatments in CCM2 cells."
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"KRAS siRNA sequences induced> 90% knockdown of KRAS expression, significantly reducing viability in mutant cell lines."
KRAS increases the amount of KRAS-G12D. 4 / 4
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"We further explored the effects of p53 restoration in lung cancer type by crossing the p53 LSL allele to the Kras LA2 allele that drives oncogenic Kras G12D expression after a spontaneous recombination event [XREF_BIBR]."
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"Kras shRNA molecules reduce the expression of both WT Kras and Kras G12D and more potent constructs than shKras.54 inhibited the growth of AML 101-R (data not shown)."
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"Here we report that Kras LSL-G12D/+; Pdx1-cre, a mouse model known for pancreatic cancer, also mediates Kras G12D expression in the stomach, causing gastric hyperplasia and metaplasia prior to the pathologic changes in the pancreas."
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"The lung epithelium of BRaf CA/+ or KRas LSL/+ littermates was infected with 10 7 pfu of Ad-Cre to initiate expression of BRAF V600E or KRAS G12D oncoproteins respectively."
Modified KRAS increases the amount of KRAS. 4 / 4
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"KRAS mRNA expression in these cells was increased up to 60-fold compared to control cells, illustrating that forced expression of mutant cDNAs using viral vectors often results in supraphysiologic KRAS levels, which complicates assessment of the biochemical and functional consequences."
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"Induction of KRAS shRNA by addition of DOX reduced KRAS protein levels (XREF_FIG, red arrow) and withdrawal of DOX restored KRAS expression to almost normal levels within 48 hours (XREF_FIG, green arrow) suggesting inducible and reversible knockdown of KRAS in these cells (note that the KRAS western blots shown in XREF_FIG were probed with an anti-KRAS antibody that binds to both wildtype and mutant KRAS)."
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"Notably, however, overexpression of the 3 ' UTR of the KRAS pseudogene KRAS1P increases KRAS levels and promotes cells growth."
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"As seen in Figures XREF_FIG and XREF_SUPPLEMENTARY, activation of KRAS transcription during starvation increased the level of wild-type KRAS, associated with an increase in the amount of free GFP generated, hence of autophagy induction."
KRAS-G12D increases the amount of KRAS-G12D. 3 / 3
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"The propensity of Kras G12D HSCs to generate T-ALL led us to investigate the effects of Kras G12D expression in early T-lineage cells."
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"Oncogenic KRAS is a key driver of human lung adenocarcinoma, and early stage lung tumors can be modeled using LoxP-Stop-LoxP Kras G12D knock-in mice (Kras LSL-G12D/+) in which expression of Cre in lung epithelial cells leads to the expression of oncogenic Kras G12D 18,19."
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"Using the CCSP Cre mouse to specifically activate expression of the oncogenic Kras G12D in Club cells, we investigated the expression of Mig-6 in CCSP Cre Kras G12D -induced lung tumors."
Mutated KRAS increases the amount of KRAS. 1 / 1
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"In H1650 mutant EGFR cells, mutant KRAS knockdown also reduced KRAS protein levels but without a significant effect on the downstream signal transduction pathways."
KRAS-G12D increases the amount of KRAS. 1 / 1
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"However, in this model, KRAS G12D cooperated with PTEN silencing to induce thyroid cancer indicating that KRAS is expressed in mouse thyrocytes."
Modified mutated KRAS increases the amount of KRAS. 1 / 1
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"Overexpression of mutant KRAS (pCMV6-KRAS G12D, Figure XREF_FIG a) led to increased expression of KRAS, CIP2A, and pERK, and increased cell proliferation."
Mutated KRAS increases the amount of mutated KRAS. 1 / 1
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"A comprehensive proteomic analysis of these exosomes showed that, depending on cell source, they contained very different constituents, with mutant KRAS cell derived exosomes having increased levels of SRC, EGFR and mutant KRAS compared to exosomes from wild-type KRAS DKs-8 cells."
Modified KRAS increases the amount of KRAS-G12D. 1 / 1
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"Diminished pancreas desmoplasia, enhanced cancer cell apoptosis, suppressed cancer cell proliferation, reduced phospho-ERK, phospho-AKT and Kras levels are noted in KTC tumors, as well as diminished oncogenic Kras G12D expression with iExosomes treatment (XREF_FIG, XREF_FIG)."
GTP-bound active KRAS increases the amount of KRAS bound to RASSF2. 1 / 1
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"RASSF2 binds directly to K-Ras in a GTP-dependent manner via the Ras effector domain."