IndraLab

Statements

Mutated KRAS increases the amount of mutated KRAS. 3 / 3
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"A comprehensive proteomic analysis of these exosomes showed that, depending on cell source, they contained very different constituents, with mutant KRAS cell derived exosomes having increased levels of SRC, EGFR and mutant KRAS compared to exosomes from wild-type KRAS DKs-8 cells."
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"As shown in Figure 1A and quantified in Figure 1B, knockdown of Smurf2 in mutant KRAS driven lung adenocarcinoma cell lines [H358 (KRASG12C) and H441 (KRASG12V)] caused ~ 60% to 80% reduction in mutan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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reach
"To examine the role of TIGAR in the development of PDAC, we utilized well-established mouse models that use Pdx1-Cre to drive pancreas expression of mutant KRAS (LSL-Kras ) alone (KC) or mutant KRAS with mutant p53 (LSL-p53 ; KPC) or with loss of p53 (p53 ; KFC)."
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