IndraLab

Statements


KRAS increases the amount of KRAS-G12D. 4 / 4
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"We further explored the effects of p53 restoration in lung cancer type by crossing the p53 LSL allele to the Kras LA2 allele that drives oncogenic Kras G12D expression after a spontaneous recombination event [XREF_BIBR]."

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"Kras shRNA molecules reduce the expression of both WT Kras and Kras G12D and more potent constructs than shKras.54 inhibited the growth of AML 101-R (data not shown)."

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"The lung epithelium of BRaf CA/+ or KRas LSL/+ littermates was infected with 10 7 pfu of Ad-Cre to initiate expression of BRAF V600E or KRAS G12D oncoproteins respectively."

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"Here we report that Kras LSL-G12D/+; Pdx1-cre, a mouse model known for pancreatic cancer, also mediates Kras G12D expression in the stomach, causing gastric hyperplasia and metaplasia prior to the pathologic changes in the pancreas."