IndraLab

Statements

KRAS-G12D increases the amount of KRAS-G12D. 7 / 7
| 7
reach
"The propensity of Kras G12D HSCs to generate T-ALL led us to investigate the effects of Kras G12D expression in early T-lineage cells."
19296721
reach
"Overall, our findings suggest that IKK2 and KRAS G12D cooperate to rapidly elevate the protein level and activity of both KRAS G12D and NRAS, contributing to an overall augmentation in the abundance o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307409
reach
"In our study, we present a knock-in model of oncogenic variant KRAS G12D that enables the "activation" of KRAS G12D expression together with production of red fluorescent protein tdTomato."
39786607
reach
"These findings indicate that IKK2 and oncogenic KRAS G12D cooperate to rapidly elevate KRAS G12D protein levels to promote extensive PanIN lesions, while KRAS G12D alone is considerably less efficient[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307409
reach
"Oncogenic KRAS is a key driver of human lung adenocarcinoma, and early stage lung tumors can be modeled using LoxP-Stop-LoxP Kras G12D knock-in mice (Kras LSL-G12D/+) in which expression of Cre in lung epithelial cells leads to the expression of oncogenic Kras G12D 18,19."
28530655
reach
"Using the CCSP Cre mouse to specifically activate expression of the oncogenic Kras G12D in Club cells, we investigated the expression of Mig-6 in CCSP Cre Kras G12D -induced lung tumors."
29191600
reach
"Lentiviruses expressing Cre recombinase together with lentiviruses expressing control or FLAG-RALY were delivered into the lungs of Kras LSL-G12D/+ mice to induce the expression of Kras G12D alone (Kr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36952348