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Mutated KRAS increases the amount of KRAS. 3 / 3
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"We observed that mutant KRAS modestly suppressed p53 protein expression but increased p21 protein expression at the highest levels of KRAS activation (Fig. 3A)."
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"In H1650 mutant EGFR cells, mutant KRAS knockdown also reduced KRAS protein levels but without a significant effect on the downstream signal transduction pathways."
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"As reported earlier, we also observed that siRNA mediated downregulation of beta-TrCP1 in mutant KRAS driven H358 and H441 cells enhances KRAS steady-state level; overexpression of beta-TrCP1 causes d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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