IndraLab

Statements

EGF leads to the phosphorylation of IRS1 on tyrosine. 9 / 9
2 | 7
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"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
25361902
bel
"epidermal growth factor and interleukin-4 elicit tyrosine phosphorylation of IRS1"
9553137
reach
"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."
7835273
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"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
19997558
reach
"Both insulin and EGF increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2, whereas EGF is also capable of activating additional PI 3-kinase pools and, thus, can augment the downstream signaling of insulin in insulin resistant states like Type 2 diabetes."
12138086
reach
"Maximal PI 3-kinase activity (1.8- and 2.5-fold respectively) was measured after 5-10 min of incubation and was followed by a rapid decrease to basal values.To determine whether EGF- and FGF stimulate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
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"Taken together, these results confirmed previous data obtained with the pharmacological inhibitors and demonstrated that EGF and FGF inhibit the IGF-I signaling pathway through PKD1.Since PKD1 is invo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
reach
"We demonstrated that IGF-I-induced IRS-1 tyrosine phosphorylation and subsequent PI 3-kinase activation were inhibited by epidermal growth factor (EGF) or fibroblast growth factor (FGF) treatment."
22227580
bel
"EGF increased the tyrosine phosphorylation of several proteins (the EGF receptor,insulin receptor substrate (IRS)-1, IRS-2, and Grb2-associated binder 1)"
12138086
EGF leads to the phosphorylation of IRS1. 8 / 8
| 4 4
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"These investigators have documented that an endosomal fraction is the primary site for EGF stimulated Shc phosphorylation and Grb2 recruitment in addition to insulin stimulated IRS1 phosphorylation an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10884687
sparser
"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [ xref , xref ], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF-induced IRS-1 tyrosine phosphorylation in EGFR-transfected CHO cells [ xref ]."
21939528
reach
"Inhibition of PI 3-kinase totally impaired the EGF- and FGF induced serine 307 phosphorylation of IRS-1."
22227580
reach
"Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3."
11875115
sparser
"Whereas the EGF-induced phosphorylation of the EGFR and the adapter protein insulin-receptor substrate 1 (IRS1) was drastically reduced by gefitinib ( xref ) the phosphorylation of Akt was not ( xref ), indicating that Akt signaling was unchanged in gefitinib-treated H460 cells."
22815959
sparser
"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."
7835273
sparser
"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2 ."
19997558
reach
"Taken together, these results demonstrated that the serine 307 phosphorylation of IRS-1 induced by EGF and FGF is mediated by a PI 3-kinase-dependent but a PKD1 independent signaling pathway.Knowledge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
EGF leads to the phosphorylation of IRS1 on Y612. 2 / 2
| 1 1
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"Conversely, EGF stimulation resulted in elevated phosphorylation of Erk1/2, IRS-1 (Y612), and IRS-1 Y896."
25886138
sparser
"EGF did not induce IRS1 phosphorylation at Tyr612."
35159006
EGF leads to the phosphorylation of IRS1 on Y896. 2 / 2
| 2
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"Interestingly, simultaneous inhibition of both IGF-IR and EGFR and Her -2 by NVP-AEW541 and lapatinib completely abrogated IGF-I-, EGF-, and IGF-I+ EGF stimulated phosphorylation of Akt, Erk1/2, IRS-1 (Y612) and IRS-1 (Y896), confirming at the molecular level the strong synergy observed in cytotoxicity experiments."
25886138
reach
"Conversely, EGF stimulation resulted in elevated phosphorylation of Erk1/2, IRS-1 (Y612), and IRS-1 Y896."
25886138
EGF leads to the phosphorylation of IRS1 on S307. 2 / 2
| 2
reach
"Taken together, these results demonstrated that the serine 307 phosphorylation of IRS-1 induced by EGF and FGF is mediated by a PI 3-kinase-dependent but a PKD1 independent signaling pathway.Knowledge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
reach
"As shown in Fig. 9 A, EGF and FGF strongly stimulated the phosphorylation of IRS-1 on serine 307."
22227580
EGF leads to the phosphorylation of IRS1 on S629. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983