A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGF leads to the phosphorylation of IRS1 on tyrosine. 6 / 6
2 | 4
reach
"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
bel
"epidermal growth factor and interleukin-4 elicit tyrosine phosphorylation of IRS1"
reach
"Both insulin and EGF increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2, whereas EGF is also capable of activating additional PI 3-kinase pools and, thus, can augment the downstream signaling of insulin in insulin resistant states like Type 2 diabetes."
bel
"EGF increased the tyrosine phosphorylation of several proteins (the EGF receptor,insulin receptor substrate (IRS)-1, IRS-2, and Grb2-associated binder 1)"
reach
"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
reach
"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."
EGF leads to the phosphorylation of IRS1. 5 / 5
| 4 1
sparser
"Whereas the EGF-induced phosphorylation of the EGFR and the adapter protein insulin-receptor substrate 1 (IRS1) was drastically reduced by gefitinib ( xref ) the phosphorylation of Akt was not ( xref ), indicating that Akt signaling was unchanged in gefitinib-treated H460 cells."
reach
"Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3."
sparser
"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [ xref , xref ], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF-induced IRS-1 tyrosine phosphorylation in EGFR-transfected CHO cells [ xref ]."
sparser
"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."
sparser
"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2 ."
EGF leads to the phosphorylation of IRS1 on Y896. 2 / 2
| 2
reach
"Interestingly, simultaneous inhibition of both IGF-IR and EGFR and Her -2 by NVP-AEW541 and lapatinib completely abrogated IGF-I-, EGF-, and IGF-I+ EGF stimulated phosphorylation of Akt, Erk1/2, IRS-1 (Y612) and IRS-1 (Y896), confirming at the molecular level the strong synergy observed in cytotoxicity experiments."
reach
"Conversely, EGF stimulation resulted in elevated phosphorylation of Erk1/2, IRS-1 (Y612), and IRS-1 Y896."
EGF leads to the phosphorylation of IRS1 on S629. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
EGF leads to the phosphorylation of IRS1 on Y612. 1 / 1
| 1
reach
"Conversely, EGF stimulation resulted in elevated phosphorylation of Erk1/2, IRS-1 (Y612), and IRS-1 Y896."