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EGF leads to the phosphorylation of IRS1. 8 / 8
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"These investigators have documented that an endosomal fraction is the primary site for EGF stimulated Shc phosphorylation and Grb2 recruitment in addition to insulin stimulated IRS1 phosphorylation an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [ xref , xref ], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF-induced IRS-1 tyrosine phosphorylation in EGFR-transfected CHO cells [ xref ]."

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"Inhibition of PI 3-kinase totally impaired the EGF- and FGF induced serine 307 phosphorylation of IRS-1."

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"Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3."

sparser
"Whereas the EGF-induced phosphorylation of the EGFR and the adapter protein insulin-receptor substrate 1 (IRS1) was drastically reduced by gefitinib ( xref ) the phosphorylation of Akt was not ( xref ), indicating that Akt signaling was unchanged in gefitinib-treated H460 cells."

sparser
"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."

sparser
"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2 ."

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"Taken together, these results demonstrated that the serine 307 phosphorylation of IRS-1 induced by EGF and FGF is mediated by a PI 3-kinase-dependent but a PKD1 independent signaling pathway.Knowledge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"