IndraLab
Statements
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"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [ xref , xref ], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF-induced IRS-1 tyrosine phosphorylation in EGFR-transfected CHO cells [ xref ]."
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"Whereas the EGF-induced phosphorylation of the EGFR and the adapter protein insulin-receptor substrate 1 (IRS1) was drastically reduced by gefitinib ( xref ) the phosphorylation of Akt was not ( xref ), indicating that Akt signaling was unchanged in gefitinib-treated H460 cells."