IndraLab
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"Interestingly, simultaneous inhibition of both IGF-IR and EGFR and Her -2 by NVP-AEW541 and lapatinib completely abrogated IGF-I-, EGF-, and IGF-I+ EGF stimulated phosphorylation of Akt, Erk1/2, IRS-1 (Y612) and IRS-1 (Y896), confirming at the molecular level the strong synergy observed in cytotoxicity experiments."