IndraLab

Statements


EGF leads to the phosphorylation of IRS1 on Y896. 2 / 2
| 2

reach
"Interestingly, simultaneous inhibition of both IGF-IR and EGFR and Her -2 by NVP-AEW541 and lapatinib completely abrogated IGF-I-, EGF-, and IGF-I+ EGF stimulated phosphorylation of Akt, Erk1/2, IRS-1 (Y612) and IRS-1 (Y896), confirming at the molecular level the strong synergy observed in cytotoxicity experiments."

reach
"Conversely, EGF stimulation resulted in elevated phosphorylation of Erk1/2, IRS-1 (Y612), and IRS-1 Y896."