IndraLab

Statements

EGF leads to the phosphorylation of IRS1 on tyrosine. 9 / 9
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"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
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"epidermal growth factor and interleukin-4 elicit tyrosine phosphorylation of IRS1"
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"EGF did not stimulate tyrosine phosphorylation of the insulin receptor or insulin receptor substrate-1."
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"EGF exerts insulin like effects on glucose transport and lipolysis and can increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2."
19997558
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"Both insulin and EGF increase the tyrosine phosphorylation and activation of IRS-1 and IRS-2, whereas EGF is also capable of activating additional PI 3-kinase pools and, thus, can augment the downstream signaling of insulin in insulin resistant states like Type 2 diabetes."
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"Maximal PI 3-kinase activity (1.8- and 2.5-fold respectively) was measured after 5-10 min of incubation and was followed by a rapid decrease to basal values.To determine whether EGF- and FGF stimulate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these results confirmed previous data obtained with the pharmacological inhibitors and demonstrated that EGF and FGF inhibit the IGF-I signaling pathway through PKD1.Since PKD1 is invo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
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"We demonstrated that IGF-I-induced IRS-1 tyrosine phosphorylation and subsequent PI 3-kinase activation were inhibited by epidermal growth factor (EGF) or fibroblast growth factor (FGF) treatment."
22227580
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"EGF increased the tyrosine phosphorylation of several proteins (the EGF receptor,insulin receptor substrate (IRS)-1, IRS-2, and Grb2-associated binder 1)"
12138086