IndraLab

Statements

CTNNB1 increases the amount of CTNNB1. 10 / 205
| 1 172 2
reach
"Curcumin inhibited BCSCs migration by inhibiting beta-catenin nuclear translocation, attenuating the expression of beta-catenin transcriptional targets including pro EMT factors, along with the increased formation of E, cadherin, beta, and catenin complex and suppressed expression of epithelial markers."
30632783
reach
"Similarly, we confirmed that WT beta-catenin transfection increased expression of beta-catenin target genes including Cyclin D1 and MMP7, whereas the double mutation (S552A and S675A) abolished this e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25217103
reach
"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation."
17851558
reach
"The expression of beta-catenin in MSCs was upregulated by the transfection of a beta-catenin overexpression plasmid; in contrast, the expression was downregulated by sh-beta-catenin plasmid transfection."
32977843
reach
"Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin."
29039516
reach
"In contrast, the changes in mRNA expression of the Wnt and beta-catenin products including beta-catenin and cyclin D1 were not as distinct."
26366279
reach
"Wang et al. reported that an increase in mRNA expression of beta-catenin and axin2 in kidney tissues of patients with lupus nephritis compared with control kidney tissues, accompanied by an increase of beta-catenin protein expression XREF_BIBR Their study also showed that beta-catenin mRNA expression was significantly higher in lupus nephritis patients without renal interstitial fibrosis compared to those with renal interstitial fibrosis and increased beta-catenin mRNA expression positively correlated with the creatinine clearance rate (Ccr)."
28343144
reach
"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes including CD44 and promotes malignant transformation."
21678082
reach
"In addition, representative beta-catenin target genes increase cell proliferation of ICAM-1 and c-jun by increasing the expression of beta-catenin and Tcf/LEF."
23982808
reach
"We also identified that curcumin interrupts Wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (cyclin D1, c-myc)."
26366279
Modified CTNNB1 increases the amount of CTNNB1. 10 / 23
| 23
reach
"In addition, the expression of beta-catenin target genes, Axin2, was also increased, which supports not only high expression of beta-catenin, but also high activity."
31644894
reach
"By comparing Fig. 2 and Table 3, it was found that the effects of promoter haplotypes on mRNA expression levels were identical to their effects on asthma risks : Ht1 decreased both beta-catenin mRNA e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22579815
reach
"HONE1 hybrid cells with infected beta-catenin shRNA have reduced expression of beta-catenin and representative results from various passages of cell populations after infection of shRNA plasmids are shown in the bottom panel, Figure XREF_FIG A. beta-catenin expression was reduced by approximately 54%, 97%, 70%, and 79% in MCH4.5 and MCH4.6 cell lines at different passage levels after infection."
24073846
reach
"On the other hand, overexpression of beta-catenin in shDKK1-transfectants restored the transcription of beta-catenin, and attenuated the inhibitory effect of shDKK1 on invasion."
24325363
reach
"The translocation of intact beta-catenin to the nucleus, promotes transcription of Wnt and beta-catenin target gene, cyclin D1."
27546592
reach
"The expression of Wnt7b and beta-catenin in radial arteries was higher in end stage renal disease than in control group, and IS increased Wnt7b and beta-catenin expression in HASMCs as early as 3days after stimulation."
29195902
reach
"We next investigated the possibility that increased levels of nuclear beta-catenin in the mutant developing cerebral cortex enhance the transcription of Wnt and beta-catenin target genes."
19149881
reach
"The results showed that overexpression of beta-catenin increased beta-catenin level (XREF_FIG), and RNAi decreased beta-catenin expression (XREF_FIG)."
25727520
reach
"However there were increased levels of p-beta-Catenin and decreased levels of activated-beta-Catenin in old HMDSCs."
26332075
reach
"Moreover, overexpression of LV-beta-catenin in Se-PFPs-treated HEY and SKOV3 cells could rescue the protein expression of beta-catenin to the level similar to untreated control cells."
27058760
Mutated CTNNB1 increases the amount of CTNNB1. 4 / 4
| 4
reach
"Altogether, the results showed that beta catenin mutations found in HCCs generated by TCPOBOP alone, unlike those observed in HCCs from DENA-TCPOBOP-treated mice, do not induce the transcription of cl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30201494
reach
"Our data suggest that CTNNB1 mutations that increase beta-catenin protein levels sensitize cells to navitoclax."
23993102
reach
"Mutation of beta-catenin, APC or Axin found in several human cancers was reported to cause elevated beta-catenin levels and yield inappropriate activation of TCF target genes such as c-Myc and cyclin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19563778
reach
"Activation of beta-catenin transcription by APC mutations or mutations of beta-catenin itself is not functionally equivalent to an up-regulated Wnt initiated signalling because Wnt activates, except for the canonical beta-catenin pathway another pathway that through kinases Tak1 and Nlk (Nemo like kinase) phosphorylates and inhibits TCF4 [XREF_BIBR] finely tuning transcriptional activity under physiologic conditions."
17488476
Phosphorylated CTNNB1 increases the amount of CTNNB1. 3 / 3
| 3
reach
"37 Mutations in the beta-catenin phosphorylation region can activate beta-catenin signaling by upholding cellular beta-catenin levels."
29188076
reach
"Phosphorylation-mediated ubiquitination of β-catenin by β-TrCP and induced proteasomal degradation resulted in a low level of β-catenin in the cytoplasm."
32074995
reach
"MP has been shown to up-regulate the expression and activation of the beta-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 (LRP) pho sphorylation, beta-catenin, and glycogen synthase kinase-3beta (GSK) phosphorylation (XREF_FIG) [XREF_BIBR]."
30582938
CTNNB1 bound to lef increases the amount of CTNNB1. 2 / 2
| 2
reach
"In the nucleus, beta-catenin binds and activates the transcription factor LEF and TCF to initiate the transcription of Wnt and beta-catenin target genes."
30551901
reach
"In the nucleus, beta-catenin binds the transcription factor LEF and TCF to drive the transcription of Wnt and beta-catenin target genes."
28233680
CTNNB1 bound to TCF_LEF increases the amount of CTNNB1. 2 / 2
| 2
reach
"In the nucleus, beta-catenin binds the transcription factor LEF and TCF to drive the transcription of Wnt and beta-catenin target genes."
28233680
reach
"In the nucleus, beta-catenin binds and activates the transcription factor LEF and TCF to initiate the transcription of Wnt and beta-catenin target genes."
30551901
CTNNB1-T41A increases the amount of CTNNB1. 2 / 2
1 | 1
bel
"From mutations file"
11170292
reach
"This beta-catenin T41A mutant protein has increased stability, and has been previously shown to significantly up-regulate the expression of beta-catenin target genes XREF_BIBR, XREF_BIBR."
23285165
CTNNB1 bound to PKD1 increases the amount of CTNNB1. 2 / 2
| 2
reach
"We demonstrate that PKD1 directly interacts with beta-catenin and attenuates beta-catenin transcriptional activity by decreasing nuclear beta-catenin levels."
25149539
reach
"In vitro investigation revealed that PKD1 directly interacts with beta-catenin and attenuates beta-catenin transcriptional activity by decreasing nuclear beta-catenin levels."
25149539
CTNNB1 phosphorylated on amino acid 44 increases the amount of CTNNB1. 1 / 1
| 1
reach
"XREF_BIBR - XREF_BIBR CK2 has been previously reported to phosphorylate beta-catenin at Thr393, 44 which increases beta-catenin expression via ubiquitin-proteasome system and activates Wnt signaling pathway."
33602894
CTNNB1 bound to CDH1 increases the amount of CTNNB1. 1 / 1
| 1
reach
"Alternatively, the interaction between E-cadherin and beta-catenin at the adherens junction raises the intriguing possibility that the loss of E-cadherin function may actively regulate the levels of free beta-catenin, thereby altering its ability to regulate target genes that support tumor invasion."
12810698
CTNNB1-S45F increases the amount of CTNNB1. 1 / 1
| 1
reach
"Our results showed that the transfection of CTNNB1 T41A or S45F mutation had no effect on the expression of total beta-catenin; however, the transfection of CTNNB1 S45F mutation induced the nuclear expression of beta-catenin, suggesting that this specific mutation might affect beta-catenin translocation to the nucleus independent of cell type."
32651460
CTNNB1 increases the amount of phosphorylated CTNNB1. 1 / 1
| 1
reach
"To test if the S33F mutation in beta-catenin increases the amount of non phosphorylated beta-catenin in cells, we measured the amount of total and non phosphorylated beta-catenin using cell fractionation followed by Western blotting."
29872041
Tyrosine-phosphorylated CTNNB1 increases the amount of CTNNB1. 1 / 1
| 1
reach
"Contrary to phosphorylation on S33/S37/T41, beta-catenin tyrosine phosphorylation on Y86 is enhanced in CEACAM1 low cell populations exhibiting comparable total nuclear beta-catenin levels."
27572314
CTNNB1 bound to factor increases the amount of CTNNB1. 1 / 1
| 1
reach
"Then, beta-catenin is carried into the nucleus and forms a complex with T cell factor and lymphocyte enhancer factors (TCF/LEF) to activate the expression of beta-catenin responsive genes, such as c-J[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27568288
Acetylated CTNNB1 increases the amount of CTNNB1. 1 / 1
| 1
reach
"In addition, because acetylation of beta-catenin can enhance the transcription of beta-catenin, increase in acetylation of beta-catenin could enhance the expression of beta-catenin."
29069825
CTNNB1 acetylated on K49 increases the amount of CTNNB1. 1 / 1
1 |
bel
"Upon HDAC6 inhibition, Ac- Lys49 β-catenin levels increased in NPCs, which was accompanied by increased membrane localization of β-catenin."
25546293
CTNNB1 bound to enhancer factors increases the amount of CTNNB1. 1 / 1
| 1
reach
"Then, beta-catenin is carried into the nucleus and forms a complex with T cell factor and lymphocyte enhancer factors (TCF/LEF) to activate the expression of beta-catenin responsive genes, such as c-J[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27568288
Unphosphorylated CTNNB1 increases the amount of CTNNB1. 1 / 1
| 1
reach
"Dephosphorylation of beta-Catenin does not inactivate beta-Catenin but actually prevents proteasomal degradation and increases cellular levels of beta-Catenin."
21092273
CTNNB1 bound to hTcf-4 nuclear increases the amount of CTNNB1. 1 / 1
| 1
reach
"The results are in concordance with previous studies where beta-catenin protein levels have been found to be downregulated XREF_BIBR and the beta-catenin and hTcf -4 nuclear complex reduced XREF_BIBR upon Zn stimulation in HT29-APC cells indicating, decreased levels of nuclear beta-catenin."
21437251
CTNNB1-S33Y increases the amount of CTNNB1. 1 / 1
1 |
bel
"From mutations file"
9671767
CTNNB1 bound to YWHAZ increases the amount of CTNNB1. 1 / 1
1 |
bel
"We show that one of them, 14-3-3zeta, enhances beta-catenin-dependent transcription by maintaining a high level of beta-catenin protein in the cytoplasm."
15492215
CTNNB1-K180R increases the amount of CTNNB1. 1 / 1
| 1
reach
"The consequent depletion of SET7/9 by shRNA or the mutation of the beta-catenin (K180R) significantly enhanced the expression of Wnt and beta-catenin target genes such as c-myc and cyclin D1 and promoted the growth of cancer cells."
26116705
CTNNB1 bound to ASF1A increases the amount of CTNNB1. 1 / 1
| 1
reach
"Mechanistically, ASF1A interacted with beta-catenin and promoted the transcription of beta-catenin target genes including c-MYC, cyclin D1, ZEB1 and LGR5, thereby stimulating proliferation, stemness and migration and invasion of GIC cells."
28625518
CTNNB1 bound to RORalpha increases the amount of CTNNB1. 1 / 1
| 1
reach
"The inhibition is accomplished through binding of RORalpha to beta-catenin, which suppresses the transcription of Wnt and beta-catenin target genes."
23443091
CTNNB1 phosphorylated on serine and an unknown residue increases the amount of CTNNB1. 1 / 1
| 1
reach
"In our study, in both NFs and KFs, treatment with Wnt5a induced a significant increase in the total beta-catenin level but not the phosphorylated beta-catenin levels at serine 45 and threonine 41 positions, where it is phosphorylated by casein kinase 1a to undergo degradation."
23471552
CTNNB1 phosphorylated on S552 increases the amount of CTNNB1. 1 / 1
| 1
reach
"Phosphorylation of beta-catenin at S552 by AKT has also been found to enhance beta-catenin protein levels and nuclear signaling by standard reporter assays, although the precise mechanism remains unclear."
19623618