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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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CTNNB1 increases the amount of CTNNB1. 6 / 137
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"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation."
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"Furthermore, the administration of a Wnt and beta-catenin agonist upregulated the expression of beta-catenin and the Bcl-2 and Bax ratio."
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"In BM-MSCs from wild-type cells, beta-catenin nuclear activity increases proportionally to the amount of exogenous beta-catenin (XREF_FIG, blue bars)."
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"Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin."
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"Accordingly, we previously demonstrated that over-expression of beta-catenin slightly activates Tcf/Lef mediated transcription in melanocyte lineages XREF_BIBR but is not sufficient to prime the melanogenic program XREF_BIBR, suggesting that even if beta-catenin could synergize with other pathways the exclusive presence of a large amount of nuclear beta-catenin is not sufficient to activate the melanogenic program."
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"In contrast, the changes in mRNA expression of the Wnt and beta-catenin products including beta-catenin and cyclin D1 were not as distinct."
Modified CTNNB1 increases the amount of CTNNB1. 10 / 20
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"Additionally, compared with the blank and the NC groups, the LINC00968 vector and si-WNT2 groups had decreased levels of beta-catenin, GSK3beta and Vimentin, downregulated phosphorylation levels of beta-catenin and GSK3beta, and elevated level of E-cadherin (all p < 0.05)."
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"The expression of Wnt7b and beta-catenin in radial arteries was higher in end stage renal disease than in control group, and IS increased Wnt7b and beta-catenin expression in HASMCs as early as 3days after stimulation."
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"We demonstrate that overexpression of membrane tethered beta-catenin elevates the level of free endogenous beta-catenin, which subsequently accumulates in nuclei."
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"Consequently, beta-catenin transcription and translation was down-regulated, decreasing beta-catenin levels in the cytoplasm, and ultimately inhibiting the Wnt signaling pathway."
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"We next investigated the possibility that increased levels of nuclear beta-catenin in the mutant developing cerebral cortex enhance the transcription of Wnt and beta-catenin target genes."
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"Real-time PCR and Western blot assay at 48 h after infection showed that CTNNB1 knockdown in A-498 cells significantly decreased the mRNA and protein levels of CTNNB1 (XREF_FIG), whereas overexpression of CTNNB1 in 786-O (XREF_FIG) and ACHN cells (XREF_SUPPLEMENTARY) significantly increased the mRNA and protein levels of CTNNB1."
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"The results showed that overexpression of beta-catenin increased beta-catenin level (XREF_FIG), and RNAi decreased beta-catenin expression (XREF_FIG)."
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"HONE1 hybrid cells with infected beta-catenin shRNA have reduced expression of beta-catenin and representative results from various passages of cell populations after infection of shRNA plasmids are shown in the bottom panel, Figure XREF_FIG A. beta-catenin expression was reduced by approximately 54%, 97%, 70%, and 79% in MCH4.5 and MCH4.6 cell lines at different passage levels after infection."
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"Bandapalli et al. [XREF_BIBR] reported that overexpression of beta-catenin increases nuclear level of beta-catenin and carcinogenesis including metastasis."
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"However there were increased levels of p-beta-Catenin and decreased levels of activated-beta-Catenin in old HMDSCs."
CTNNB1 bound to PKD1 increases the amount of CTNNB1. 2 / 2
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"In vitro investigation revealed that PKD1 directly interacts with beta-catenin and attenuates beta-catenin transcriptional activity by decreasing nuclear beta-catenin levels."
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"We demonstrate that PKD1 directly interacts with beta-catenin and attenuates beta-catenin transcriptional activity by decreasing nuclear beta-catenin levels."
Mutated CTNNB1 increases the amount of CTNNB1. 2 / 2
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"Our data suggest that CTNNB1 mutations that increase beta-catenin protein levels sensitize cells to navitoclax."
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"Activation of beta-catenin transcription by APC mutations or mutations of beta-catenin itself is not functionally equivalent to an up-regulated Wnt initiated signalling because Wnt activates, except for the canonical beta-catenin pathway another pathway that through kinases Tak1 and Nlk (Nemo like kinase) phosphorylates and inhibits TCF4 [XREF_BIBR] finely tuning transcriptional activity under physiologic conditions."
CTNNB1-T41A increases the amount of CTNNB1. 2 / 2
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"This beta-catenin T41A mutant protein has increased stability, and has been previously shown to significantly up-regulate the expression of beta-catenin target genes XREF_BIBR, XREF_BIBR."
bel
"From mutations file"
CTNNB1 bound to ASF1A increases the amount of CTNNB1. 1 / 1
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"Mechanistically, ASF1A interacted with beta-catenin and promoted the transcription of beta-catenin target genes including c-MYC, cyclin D1, ZEB1 and LGR5, thereby stimulating proliferation, stemness and migration and invasion of GIC cells."
CTNNB1 bound to TCF_LEF increases the amount of CTNNB1. 1 / 1
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"In the nucleus, beta-catenin binds the transcription factor LEF and TCF to drive the transcription of Wnt and beta-catenin target genes."
CTNNB1 bound to RORalpha increases the amount of CTNNB1. 1 / 1
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"The inhibition is accomplished through binding of RORalpha to beta-catenin, which suppresses the transcription of Wnt and beta-catenin target genes."
Phosphorylated CTNNB1 increases the amount of CTNNB1. 1 / 1
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"37 Mutations in the beta-catenin phosphorylation region can activate beta-catenin signaling by upholding cellular beta-catenin levels."
CTNNB1 phosphorylated on serine and an unknown residue increases the amount of CTNNB1. 1 / 1
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"In our study, in both NFs and KFs, treatment with Wnt5a induced a significant increase in the total beta-catenin level but not the phosphorylated beta-catenin levels at serine 45 and threonine 41 positions, where it is phosphorylated by casein kinase 1a to undergo degradation."
CTNNB1 phosphorylated on S552 increases the amount of CTNNB1. 1 / 1
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"Phosphorylation of beta-catenin at S552 by AKT has also been found to enhance beta-catenin protein levels and nuclear signaling by standard reporter assays, although the precise mechanism remains unclear."
CTNNB1-S33Y increases the amount of CTNNB1. 1 / 1
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bel
"From mutations file"
CTNNB1 bound to YWHAZ increases the amount of CTNNB1. 1 / 1
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bel
"We show that one of them, 14-3-3zeta, enhances beta-catenin-dependent transcription by maintaining a high level of beta-catenin protein in the cytoplasm."
CTNNB1-K180R increases the amount of CTNNB1. 1 / 1
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"The consequent depletion of SET7/9 by shRNA or the mutation of the beta-catenin (K180R) significantly enhanced the expression of Wnt and beta-catenin target genes such as c-myc and cyclin D1 and promoted the growth of cancer cells."
CTNNB1 bound to CDH1 increases the amount of CTNNB1. 1 / 1
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"Alternatively, the interaction between E-cadherin and beta-catenin at the adherens junction raises the intriguing possibility that the loss of E-cadherin function may actively regulate the levels of free beta-catenin, thereby altering its ability to regulate target genes that support tumor invasion."
CTNNB1 bound to lef increases the amount of CTNNB1. 1 / 1
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"In the nucleus, beta-catenin binds the transcription factor LEF and TCF to drive the transcription of Wnt and beta-catenin target genes."
CTNNB1 bound to hTcf-4 nuclear increases the amount of CTNNB1. 1 / 1
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"The results are in concordance with previous studies where beta-catenin protein levels have been found to be downregulated XREF_BIBR and the beta-catenin and hTcf -4 nuclear complex reduced XREF_BIBR upon Zn stimulation in HT29-APC cells indicating, decreased levels of nuclear beta-catenin."
Phosphorylated CTNNB1 increases the amount of CTNNB1. 1 / 1
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"Dephosphorylation of beta-Catenin does not inactivate beta-Catenin but actually prevents proteasomal degradation and increases cellular levels of beta-Catenin."
Acetylated CTNNB1 increases the amount of CTNNB1. 1 / 1
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"In addition, because acetylation of beta-catenin can enhance the transcription of beta-catenin, increase in acetylation of beta-catenin could enhance the expression of beta-catenin."
Tyrosine-phosphorylated CTNNB1 increases the amount of CTNNB1. 1 / 1
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"Contrary to phosphorylation on S33/S37/T41, beta-catenin tyrosine phosphorylation on Y86 is enhanced in CEACAM1 low cell populations exhibiting comparable total nuclear beta-catenin levels."
CTNNB1 increases the amount of phosphorylated CTNNB1. 1 / 1
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"To test if the S33F mutation in beta-catenin increases the amount of non phosphorylated beta-catenin in cells, we measured the amount of total and non phosphorylated beta-catenin using cell fractionation followed by Western blotting."