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CTNNB1 increases the amount of CTNNB1. 175 / 205
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"Curcumin inhibited BCSCs migration by inhibiting beta-catenin nuclear translocation, attenuating the expression of beta-catenin transcriptional targets including pro EMT factors, along with the increased formation of E, cadherin, beta, and catenin complex and suppressed expression of epithelial markers."
30632783
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"Similarly, we confirmed that WT beta-catenin transfection increased expression of beta-catenin target genes including Cyclin D1 and MMP7, whereas the double mutation (S552A and S675A) abolished this e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25217103
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"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation."
17851558
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"The expression of beta-catenin in MSCs was upregulated by the transfection of a beta-catenin overexpression plasmid; in contrast, the expression was downregulated by sh-beta-catenin plasmid transfection."
32977843
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"Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin."
29039516
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"In contrast, the changes in mRNA expression of the Wnt and beta-catenin products including beta-catenin and cyclin D1 were not as distinct."
26366279
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"Wang et al. reported that an increase in mRNA expression of beta-catenin and axin2 in kidney tissues of patients with lupus nephritis compared with control kidney tissues, accompanied by an increase of beta-catenin protein expression XREF_BIBR Their study also showed that beta-catenin mRNA expression was significantly higher in lupus nephritis patients without renal interstitial fibrosis compared to those with renal interstitial fibrosis and increased beta-catenin mRNA expression positively correlated with the creatinine clearance rate (Ccr)."
28343144
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"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes including CD44 and promotes malignant transformation."
21678082
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"In addition, representative beta-catenin target genes increase cell proliferation of ICAM-1 and c-jun by increasing the expression of beta-catenin and Tcf/LEF."
23982808
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"We also identified that curcumin interrupts Wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (cyclin D1, c-myc)."
26366279
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"We also showed that CENPK was directly bound to SOX6 and disrupted the interactions of CENPK with β-catenin, which promoted β-catenin expression and nuclear translocation, facilitated p53 ubiquitination, and led to activation of Wnt/β-catenin signaling, but suppression of the p53 pathway."
35418160
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"Wnt and beta-catenin pathway activator treatment significantly promoted HDPC proliferation and upregulated the expression of beta-catenin (P < 0.05)."
33290799
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"Moreover, beta-catenin can increase the transcription of downstream beta-catenin signaling pathway related genes, including VEGF, MMP2, and MMP7, thereby leading to tumor cell proliferation and metastasis XREF_BIBR, XREF_BIBR."
31004081
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"In addition, silencing of beta-catenin down-regulated Sox4, nuclear beta-catenin and total beta-catenin expressions, while overexpression of beta-catenin up-regulated the expressions of these factors (XREF_FIG)."
29490000
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"LiCl, a stimulant of beta-catenin, was added into the cultures of PBMCs to increase the beta-catenin expression."
33628846
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"The expression of β-catenin, Runx2, and Osterix was markedly reduced by β-catenin knockdown, as compared to negative control, in both the absence and presence of 7,8-DHF (p<0.05) (Figure 2J–M, Figure 2—figure supplement 1)."
34227467
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"More important, knockdown of beta-catenin through siRNA not only markedly inhibited the expression of beta-catenin as well as its downstream targets c-Myc and cyclinD1 (XREF_FIG H-I), but also abrogated the effects of CBX4 on cell growth and colony formation in soft agar (XREF_FIG J-L)."
33387960
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"These results were supported by Western analysis, in which beta-catenin knockdown in mice subjected to Ad-HO-1 or Ad-IL-10 diminished the expression of beta-catenin (XREF_FIG, 0.2-0.5 AU) in the ischemic liver lobes, whereas NS siRNA followed by Ad-HO-1 or Ad-IL-10 did not affect beta-catenin levels (2.0-2.3 AU)."
23081841
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"The subcellular location of beta-catenin and cyclin D1 in 100 CMT samples was investigated via immunohistochemical analysis, and significantly increased expressions of beta-catenin in cytoplasm and cyclin D1 in nuclei were revealed."
27586466
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"We found that CTNNB1 knockdown reduced beta-catenin expression and inhibited proliferation of H295 R cells."
33287648
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"Dissociation of beta-catenin from cadherin elevates levels of nuclear beta-catenin, a frequent occurrence in tumorigenesis [XREF_BIBR]."
26908451
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"The increased concentration of beta-catenin protein in the cytoplasm favors its translocation to the nucleus as a coactivator for the TCF/LEF (T-cell factor and lymphoid enhancer factor) family and activates the transcription of Wnt and beta-catenin target genes, such as c-myc and cyclin D1, which function as oncogenes XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
23613813
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"The transfection of β-catenin siRNA decreased the protein expression of β-catenin in BON1 and NCI-H727 cells to 42 ± 16% and 49 ± 8%, compared to control transfection of non-targeting control (β-actin) siRNA (Figure 9A,B)."
32033025
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"The Wnt signaling function of beta-catenin is mediated by ' free ' cytoplasmic beta-catenin, which increases the transcription of Wnt and beta-catenin target genes by forming a complex with LEF and TCF (lymphoid enhancer factor/T cell factor; TCF) DNA binding proteins."
20228844
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"Mechanistically, deletion of Capns1 elevated the protein levels of beta-catenin in endothelial cells of Capns1-KO mice and constitutive activity of calpain 2 suppressed beta-catenin protein expression in cultured endothelial cells."
30778623
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"Suppression of the transactivation effects of beta-catenin and Tcf with FH535 ((N-(2-methyl-4-nitro) -2,4-dichlorosulfonamide, a beta-catenin and Tcf inhibitor) significantly decreased the protein levels of beta-catenin and METTL3, and then increased the levels of pp53, in TP53-Dox cells (XREF_FIG)."
30578766
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"Silencing of beta-catenin reduced the basal level of total beta-catenin (XREF_FIG)."
29765214
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"Activation of the Wnt and beta-catenin pathway by LiCl or Wnt3a increased beta-catenin protein levels in monocytes but not in granulocytes."
16565323
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"Our results indicate that the removal of miRNA regulation of beta-catenin by using miRNA TP MASO is able to induce an increase in beta-catenin protein level by the 32-cell stage (6 hpf) and in both mRNA and protein levels by mesenchyme blastula stage (XREF_FIG)."
25614238
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"When translocated into the nucleus, β-catenin binds to the TCF/Lef complex and promotes the expression of β-catenin target genes [6–8]."
29845518
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"It is not known whether the increased beta-catenin and YAP mRNAs lead to increased protein expression of beta-catenin and YAP in mice with intermittent fasting."
25982698
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"Although beta-catenin level is dramatically decreased, beta-catenin is still able to translocate into the nucleus (XREF_SUPPLEMENTARY), and activate beta-catenin and Tcf dependent transcription (XREF_FIG) in GEO cells with Pdcd4 knock-down."
19784072
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"Mutations in both β-catenin and its destruction complex components can increase nuclear β-catenin levels, have been observed in many tumors and are directly associated with human tumorigenesis [15,16]."
31658259
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"A preclinical study has demonstrated that the inhibition of Wnt and beta-catenin pathway induced lower levels of nuclear beta-catenin, resulting in downregulation of the beta-catenin-targeted genes such as MMP-9, cyclin-D, c-myc, and survivin [XREF_BIBR]."
22448123
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"Hemizygous Ctnnb1 gene dosage was associated with an inability of Apc bi-allelic inactivation to activate Ctnnb1 transcript levels in proximal colon tissues (XREF_FIG)."
26528816
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"No difference between groups was found in levels of nuclear cyclin D1 or beta-catenin, however, nuclear beta-catenin was increased in plant sterol fed female compared to plant sterol fed male (2.2 +/-0.2 and 1.3 +/-0.4, respectively; p = 0.011)."
| PMC
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"The present observation that the inhibitor of beta-catenin signaling, XAV939, impairs not only the amount of active beta-catenin but also the expression of PFKP in a manner similar to that of WNT5A signaling supports the idea that WNT5A impairs aerobic glycolysis in breast cancer cells via reduced beta-catenin signaling."
29069720
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"Unlike in pulmonary blastoma and low-grade ADC of fetal lung type, wherein aberrant beta-catenin expression induced by beta-catenin (CTNNB1) gene mutation can be observed frequently [9], only 2 cases [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"67,81-83 beta-Catenin protein expression in iron loaded primary rat hepatocytes may be similar to control cultures in that the degradation of beta-catenin may be inhibited to maintain the appropriate [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12651624
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"Portal-Nunez et al. [XREF_BIBR] also observed the STZ induced DM rat models with the parathyroid treatment group as the control, using the gene chip technology and rt-PCR analysis of Wnt and beta-catenin signal pathway change and analysis of beta-catenin protein expression by immunohistochemical method change."
26495008
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"Knockdown of YB-1 in hepatocellular carcinoma cells disrupted stemness and suppressed β-catenin protein expression and nuclear translocation, which was rescued by overexpression of the active form of β-catenin (Chao et al., 2017)."
31632972
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"According to the results (Fig. 4a), 0.25, 0.5, 0.75, and 1 μg siRNA interfered with β-catenin expression, of which 0.5 μg siRNA significantly lowered β-catenin expression (p < 0.05) compared to 0.25 μg siRNA, while 0.5, 0.75, and 1 μg siRNA did not significantly downregulate β-catenin expression."
30092818
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"Gene silencing of beta-catenin abrogated the expression of beta-catenin and significantly reduced the expression of p-beta-catenin during elevated D-glucose in ECs (XREF_FIG)."
21443457
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"Beta-catenin activator (CHIRON 99021) treatment could significantly elevate expression levels of activated beta-catenin and FASL, but not TERT, in BMMSCs."
24401839
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"Downregulation of beta-Catenin Expression by FH535, XAV939, and beta-Catenin Specific siRNA."
30568936
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"The CTNNB1 level in the nucleus may also be increased by mutations in the CTNNB1 gene itself, which may interfere with normal protein degradation [XREF_BIBR, XREF_BIBR]."
27600761
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"The major output of this pathway is nuclear translocation of beta-catenin, which stimulates expression of beta-catenin responsive target genes that promote cell proliferation, differentiation, and invasion [XREF_BIBR - XREF_BIBR]."
21767405
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"As expected, beta-catenin knockdown decreased the levels of beta-catenin and its targets, including c-Myc, Cyclin D1, Axin2, and Dkk1 in both cell lines (XREF_FIG and XREF_SUPPLEMENTARY)."
24837480
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"Accumulation of beta-catenin may activate the beta-catenin transcription by TCF-4 and LEF and facilitate the oncogene expression, and eventually resulted in colorectal polyps and cancer (Fearnhead et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26625971
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"35 The stable overexpression of beta-catenin caused by mutation in APC or beta-catenin leads to an accumulation of beta-catenin in the nucleus, where it induces a set of genes encoding, for example, c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12860119
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"Stabilization of β-catenin due to multiple mechanisms including Wnt secretion likely from macrophages, secondary to AKT mediated GSK3β inhibition and via de novo β-catenin transcription, attempts to compensate to maintain homeostasis in the Raptor ∆HC mice."
35555377
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"Western blotting and RT-qPCR assays confirmed that the β-catenin vector strongly increased β-catenin expression in NCI-H1299 and NCI-H460 cells (Fig. 4a, b)."
33893396
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"Results show that both ALDOB and ALDOC had no effect on Wnt and beta-catenin mediated transcription or beta-catenin protein levels in these cells thus suggesting that the destruction complex may be required for the activity of Aldolase."
24993527
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"To further examine the role of β-catenin in osteoblast differentiation, β-catenin small interfering RNA (siRNA) (Si-β-cat) was used to knockdown β-catenin expression in osteoblast."
32070052
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"Furthermore, this study showed that GA-DM interrupts Wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF, and cyclin D1)."
29399381
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"Further studies are needed to better understand the details of the apparent feed-forward mechanisms through which beta-catenin and beta-catenin and TCF transcription may regulate Ctnnb1 and CTNNB1 transcription in the setting of Apc and APC inactivation."
26528816
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"Β-catenin was highly expressed in primary and metastatic BC, overexpression of β-catenin increased the colony formation of MCF7 cells when it was co-expressed with HER2 and synergically increased the tumor size in immunodeficient mice."
37331014
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"We next examined whether beta-catenin and TCF-LEF pathway mediates the effects of SATB2 in CSCs by measuring the expression of beta-catenin and TCF-LEF targets, and TCF-LEF transcriptional activity."
28887549
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"In conclusion, these data provide evidences that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin targeted genes and myogenesis in the muscle derived stem cells of cattle."
21402455
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"Thus, Wnt and beta-catenin signalling pathway activation is strongly induced by APC gene mutations, and increases in beta-catenin expression can promote CRC cell proliferation."
28164117
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"Beta-Catenin spared from phosphorylation by GSK3beta translocates into the nucleus and binds to TCF/LEF promoter, thereby enhancing the transcription of Axin-2, CD44, c-Myc, CCND1, and beta-catenin itself [XREF_BIBR]."
28289330
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"Interestingly, Akt1 gene silencing in HLEC resulted in the increased presence of β-catenin in the cytosol and nucleus from its normal localisation in the endothelial adherens junctions, and treatment with ICG001 and IWR-1 that prevent β-catenin nuclear localisation restored β-catenin expression in the cell–cell junctions (Fig. 2e; Supplemental Fig. 1A)."
29755115
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"In MM cells, as expected, beta-catenin protein levels were reduced by DFX treatment, accompanied by decreased levels of phosphorylated-GSK-3beta (inactive form), resulting in the degradation of beta-catenin."
27602957
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"In AML, MUC1-C associates with the beta, catenin, and TCF4 complex, which regulates cell proliferation and differentiation.5, 12 Accumulation of beta-catenin in the cytoplasm promotes its translocation to the nucleus as a cofactor for transcription factors of the T-cell factor (TCF) family and activates the transcription of Wnt and beta-catenin target genes."
29761849
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"By comparison in colonic adenocarcinomas, elevated beta-catenin levels caused by mutations in CTNNB1 or APC result in activation of the Wnt/beta-catenin/LEF1 pathway through a LEF1 binding site in the cyclin D1 promotor, triggering cyclin D1 gene expression, and subsequently, uncontrolled progression of tumor cells into the cell cycle [XREF_BIBR, XREF_BIBR]."
20368795
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"APC is effective at least in part by degrading beta-catenin and lack of APC leads to markedly enhanced cellular beta-catenin levels."
21476133
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"CTNNB1 overexpression partly restored proliferation repressed by sh‐SNHG12#1, and joint overexpression of CTNNB1 and BMI1 furthered the restoration (Fig. 7B,C)."
32239639
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"Hedyotis diffusa Willd inhibited beta-catenin and TCF4 gene transcription in Wnt and beta-catenin pathway, suppressed the activity of Wnt and beta-catenin, which inhibited the transcription of gene CK20 and gene CD133, and affected CSC differentiation and viability [XREF_BIBR]."
29234398
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"Pharmacologic inhibition of beta-catenin using the cyclooxygenase inhibitor indomethacin reduces beta-catenin levels and leads to a reduction in LSCs."
28479420
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"Western blot analysis showed that the constitutively active beta-catenin (beta-catenin-C) increased the expression levels of beta-catenin."
27281614
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"Of note, mRNA expression of CTNNB1 gene encoding β-catenin is likely not affected by mutations in WNT/β-catenin pathway genes, as these stabilise and enhance β-catenin expression by preventing its ubiquitylation and/or proteasomal degradation."
34389725
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"To determine whether active beta-catenin levels in mutant cells can be restored by pharmacological Wnt and beta-catenin activators, we treated control and GD NPCs with the GSK3beta inhibitor CHIR, which prevents beta catenin destruction."
29198828
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"First, Wnt and beta-catenin signaling inhibitor (DKK1) and Smad3 inhibitor (SIS3) both could effectively inhibit the expression of beta-catenin and p-Smad3 respectively in MSCs on PCL nanofiber scaffolds."
28646917
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"Beta-Catenin and T-cell factor dependent promoter activity was markedly activated in PDK1- and PKCalpha expressing cells, but not in Akt1 expressing cells, which resulted in increased levels of the beta-catenin and T-cell factor target genes c-myc and cyclin D1."
14500370
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"Furthermore, it is suggested that beta-catenin over-expression is not caused by genetic alteration of either the beta-catenin or the APC gene."
10709091
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"Clearly, pBabe-HSF1 transfection in the beta-catenin FL/FL cells markedly increased HSF1 and beta-catenin expression but inhibited TLR4 expression (XREF_FIG) compared to the control vector transfected cells."
27474884
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"As beta-catenin functions as a transcriptional co-activator to promote cell proliferation after being transported into the nucleus [XREF_BIBR, XREF_BIBR], we guess that the increased beta-catenin and active-beta-catenin in the nucleus after YAP over-expression may promote the transcription of beta-catenin target genes."
28962630
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"Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation."
17851558
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"Arguably, perhaps the key consequence of the loss-of-function mutations in APC and the Axins or the gain-of-function mutations in beta-catenin is to elevate beta-catenin levels in the cytoplasm and nu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12086873
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"Moreover, the cytoplasmic and nuclear accumulation of beta-catenin could be observed in premalignant lesions (atrophic gastritis and IM) [XREF_BIBR], and increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type GC [XREF_BIBR]."
25962957
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"Nuclear beta-catenin increases the TCF reporter activity and enhances beta-catenin target gene expression such as cyclin D1, c-myc, and MMP-7."
28977889
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"Furthermore, β-catenin IHC staining demonstrated that subcutaneous tumors formed by full-length SPINT1-AS1 overexpressed HeLa cells had increased β-catenin expression compared with those formed by control HeLa cells, which was largely reversed by the deletion of DNM3OS binding site on SPINT1-AS1 (Figure 6E)."
34350182
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"Therefore, with the activation of GSK3beta, total beta-catenin was reduced, which also resulted in reduced expression of active beta-catenin in CMTM6 depleted cisplatin resistant lines."
33434185
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"Nuclear expression of beta-catenin was down-regulated in LN229 and U87 glioma cells by a small molecule inhibitor of beta-catenin and TCF4 signaling, demonstrating strongly inhibited beta-catenin and TCF4 transcriptional activity and STAT3 luciferase activity, as well as decreased mRNA and protein levels of nuclear beta-catenin, TCF4, EGFR, AKT1, AKT2 and STAT3."
22415719
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"Silencing circβ-catenin reduces the β-catenin expression, thereby inhibiting cell invasiveness, which promotes circRNA as a favorable candidate for therapeutic targets [53,94]."
32781555
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"Activation of beta-catenin signalling upregulates the expression of Wnt and beta-catenin target genes including Axin2."
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"It has been reported that Wnt1 and β -catenin depletion and overexpression of nuclear β -catenin, together with TCF binding sites activation, demonstrates that ABCB1 in CML is positively regulated by the canonical pathway of Wnt signaling [ xref ]."
32149112
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"Because silence of circβ-catenin suppressed the protein level of β-catenin without affecting the RNA level of β-catenin, we thus speculated that circβ-catenin might modulate the expression of β-catenin in protein level rather than the transcription level."
31027518
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"Moreover, FOXP4, a transcription factor of β-catenin, promotes the transcription of β-catenin and ultimately leads to the malignant progression of ESCC."
34970490
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"Detected by proteomic approaches, members of the Wnt and beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis."
17330951
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"Reduction in either beta-catenin or TNKS was sufficient to decrease expression of beta-catenin transcriptional targets, as demonstrated by a reduction in the expression of MYC, CCND1, AXIN2, LEF1, and BIRC5 (XREF_SUPPLEMENTARY)."
23535903
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"Increased betacatenin activity in Mll-Ell + cells activates transcription of betacatenin target genes, including CDX4 and HOXA10, in an Fgf2 dependent manner [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
27340869
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"Three small molecules -- Inhibitor of beta-Catenin And TCF4 (ICAT), niclosamide, and XAV939 -- have been shown to strongly and specifically reduce levels of active beta-catenin in vitro by inhibiting beta-catenin stabilization and downstream beta-catenin signaling (TCF/LEF reporter activity)."
24534281
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"In BM-MSCs from wild-type cells, beta-catenin nuclear activity increases proportionally to the amount of exogenous beta-catenin (XREF_FIG, blue bars)."
22406973
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"Accordingly, we previously demonstrated that over-expression of beta-catenin slightly activates Tcf/Lef mediated transcription in melanocyte lineages XREF_BIBR but is not sufficient to prime the melanogenic program XREF_BIBR, suggesting that even if beta-catenin could synergize with other pathways the exclusive presence of a large amount of nuclear beta-catenin is not sufficient to activate the melanogenic program."
22427932
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"It has been reported Wnt1 and β -catenin depletion and overexpression of nuclear β -catenin, together with TCF binding sites activation demonstrates that ABCB1 in CML is positively regulated by the canonical pathway of Wnt signaling."
32149112
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"Here, we show that beta-catenin is differently modulated in patients with multiple sclerosis (MS), displaying that different pharmacological treatments used for clinical MS management cause different nuclear expression levels of beta-catenin."
26592242
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"Additionally, Flii overexpression resulted in decreased beta-catenin levels, inhibited Wnt and beta-catenin signalling and impaired regeneration of colonic crypts."
31488864
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"Stabilization of beta-catenin in proximal epithelium using the Catnb floxedExon3 allele raised epithelial beta-catenin levels, resulting in squamous, cuboidal, and goblet cell dysplasia in intrapulmonary conducting airways and the appearance of alveolar type 2 like cells in the bronchioles."
20691848
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"BMP/Smad signaling and Wnt/beta-catenin were activated by enhanced Smad1/5/8 phosphorylation and increased nuclear beta-catenin protein expression."
34426741
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"It is believed that accumulation of beta-catenin in the cytoplasm favors its translocation to the nucleus as a cofactor for transcription factors of the T-cell factor and lymphoid enhancing factor (TCF/LEF) family and activates the transcription of Wnt and beta-catenin target genes, which regulates cell proliferation and differentiation [XREF_BIBR]."
16959035
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"We found that PAK7 overexpression dramatically up-regulated the expression of beta-catenin, p-GSK3beta (S9) and downstream target genes cyclin D1 and c-myc, but did n't affect protein expression level of GSK-3beta in MCF-7 cells, besides that, the expression of beta-catenin and c-myc in nucleus also increased."
29805709
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"Furthermore, Yang et al. reported that Wnt3a, a representative canonical member of the Wnt family of ligands, upregulates the expression of beta-catenin and enhances the osteogenic differentiation of dental follicle cells, while dickkopf1, a Wnt and beta-catenin signalling inhibitor, decreases the expression of beta-catenin and attenuates the osteogenic differentiation of dental follicle cells 13."
28887537
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"Moreover, Wnt and beta-catenin pathway inhibitor XAV939 could inhibit the expressions of c-myc, cyclin D1 and beta-catenin, but activator LiCl could promote their expression."
32103979
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"For example, in colorectal cancer, elevated beta-catenin levels caused by mutations in CTNNB1 or the APC genes result in activation of the Wnt-beta-catenin-LEF-1 pathway through a LEF-1 binding site i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11957146
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"Furthermore, CGP049090, a small molecule inhibitor of Wnt and beta-catenin, inhibited the expression of beta-catenin (5 microM, P = 0.0227; 10 microM, P = 0.0086), c-myc (5 microM, P = 0.0213; 10 microM, P = 0.0017) and cyclin D1 (5 microM, P = 0.0243; 10 microM, P = 0.0033) in MG63 cells in a concentration dependent manner (XREF_FIG)."
27602115
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"Activation of WNT signalling leads to stabilisation of beta-catenin which localises to the nucleus and associates with TCFs to activate expression of TCF and beta-catenin target genes, such as Cyclin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19124064
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"Knockdown of beta-catenin or treatment with BC2059 that disrupts binding of beta-catenin to TBL1X (TBL1) depleted nuclear beta-catenin levels."
30575820
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"Inhibiting beta-catenin with XAV-939 effectively abrogated beta-catenin expression caused by lenvatinib treatment."
33735820
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"Beta-Catenin is upregulated in fibrotic human liver tissue, and increased beta-catenin levels in rat hepatic stellate cells were associated with collagen production and proliferation [XREF_BIBR]."
31382613
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"The activation of the coreceptors leads to stabilization of beta-catenin, indicated by the increase in presynaptic inputs when beta-catenin levels are increased either by inhibition of GSK3beta by LiCl or transfection of a constitutively active form of beta-catenin."
18986540
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"The expressions of PSMD4, ZEB1, and beta-catenin downstream genes, Cyclin D1 and c-Myc were concomitantly decreased by beta-catenin silencing."
27033953
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"Direct interaction of Notch and beta-catenin has been reported in Drosophila, in which the Notch C-terminal region to the cdc10 and ankyrin repeats is associated with Armadillo and beta-catenin and negatively regulates beta-catenin and TCF transcription."
20404113
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"Studies have shown that in osteosarcomas, FoxM1 and β-catenin directly bind to the cytoplasm and nucleus, enhancing the nuclear transcription of β-catenin, promoting its binding with TCF4 on the Wnt target gene promoter, enhancing the activity of the Wnt pathway [23]."
32035486
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"In addition, the authors proved that lncAFAP1-AS1 blocked the function of β-catenin destruction complex, which then led to the release of β-catenin and the activation of the Wnt/β-catenin signaling pathway, thus inducing the radioresistance of BRCA."
34595090
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"On the other hand, overexpressing beta-catenin (v 12) in the model also increases the basal level of beta-catenin (XREF_FIG)."
20005849
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"CagA also activates nuclear factor of activated T-cells (NFAT) signal pathway, and interacts with E-cadherin to deregulate beta-catenin signaling, which induces beta-catenin downstream genes expression such as CDX1 and promotes cell intestinal transdifferentiation [XREF_BIBR]."
23217022
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"Importantly, a novel Wnt and beta-catenin signalling inhibitor, AV65, has been reported to reduce the beta-catenin expression and inhibit the proliferation of IM resistant and hypoxia adapted CML cells [XREF_BIBR]."
23301832
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"Notably, abnormal activation of the Wnt and beta-catenin signaling pathway leads to beta-catenin accumulation in the nucleus and subsequent binding to the T cell factor (TCF) or lymphoid enhancer factor (LEF) transcription factors, thereby inducing the expression of Wnt and beta-catenin target genes, which are essential for EMT and metastatic progression of epithelial cancers."
27333045
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"Intriguingly, the mechanism governing D-DT-dependent beta-catenin transcription was found to be through stabilization of beta-catenin protein thus increasing cellular beta-catenin levels and subsequent transcription [XREF_BIBR]."
22507380
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"TMEM97 also positively regulated the β-catenin signaling pathway in CRC cells and xenografts by modulating the phosphorylated-GSK-3β and active (non-phospho) β-catenin levels."
35907137
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"Lentivirus over-expressing beta-catenin successfully up-regulated beta-catenin protein expression in TGR5 -/- BMDMs (XREF_FIG)."
31930324
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"Our aim was to investigate whether the nuclear overexpression of beta-catenin, possibly caused by mutations in exon 3 of beta-catenin (CTNNB1), is correlated with distant metastatic spread or disease-free survival in rectal carcinoma."
9788389
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"Silencing β-catenin reduced the binding level of downstream target gene β-catenin, MMP-2 and MMP-9 promoters by luciferase assay (Figure 9E, 9F)."
31895692
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"Several growth factors, such as FGF2, increase beta-catenin signaling through different mechanisms that include increasing the expression of beta-catenin mRNA, increasing nuclear translocation of beta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21184762
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"Inhibition of Src kinase by PP2 further indicates that GSLs in cell membrane may mediate the phosphorylation of cSrc and of beta-catenin that decreases beta-catenin levels in the nucleus."
20540746
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"Multiple myeloma cell lines and primary MM cells overexpress beta-catenin, XREF_BIBR, XREF_BIBR and soluble Wnt proteins increase beta-catenin protein levels and beta-catenin and TCF transcription."
25788321
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"Sirt3 deficiency not only led to the downregulation of VE-cadherin but also enhanced the transcriptional activity of beta-catenin that further increased beta-catenin target gene MMP-7 expression, thereby promoting inflammatory factor COX-2 expression."
34630854
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"LncRNA-CR594175 was significantly decreased by Lv-shRNA-CR594175 (p < 0.05), and no change in cells infected with Lv-CTNNB1 (p> 0.05) was obsserved; CTNNB1 protein level was significantly increased by Lv-CTNNB1 and decreased by Lv-shRNA-CR594175 (p < 0.05)."
32983253
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"In both BRCA2-deficient H1299 cells and BRCA1 RPE1 cells, oncogenic β-catenin triggered aberrant origin firing (Fig. 4a, b, red), relative to cells with normal β-catenin expression (Fig. 4a, b, blue)."
34389725
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"One recent report provides evidence that HPV16 E6 is able to augment beta-catenin and TCF-dependent transcription induced by Wnt3a or beta-catenin expression."
22087269
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"We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1)."
24064724
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"Real-time PCR and Western blot assay at 48 h after infection showed that CTNNB1 knockdown in A-498 cells significantly decreased the mRNA and protein levels of CTNNB1 (XREF_FIG), whereas overexpression of CTNNB1 in 786-O (XREF_FIG) and ACHN cells (XREF_SUPPLEMENTARY) significantly increased the mRNA and protein levels of CTNNB1."
28260916
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"Addition of both Wnt5a and calcium to NHEKs activated the Wnt and beta-catenin signaling pathway as indicated by (i) increased stability of beta-catenin in the cells, (ii) enhanced beta-catenin transcriptional activity, demonstrated by a luciferase based beta-catenin-activated reporter assay, and (iii) augmented Wnt and beta-catenin target gene expression."
24658506
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"In the hepatocyte, a few minutes after PH, the Wnt and beta-catenin pathway promotes increased levels and translocation of beta-catenin to the nucleus, and in cooperation with Yap and Hedgehog pathways, regulates proliferation, survival, and differentiation."
33748499
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"Furthermore, the administration of a Wnt and beta-catenin agonist upregulated the expression of beta-catenin and the Bcl-2 and Bax ratio."
26994873
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"AQP1 interacts with beta-catenin, GSK3beta, LRP6, and Axin1, and deficiency of AQP1 increased the levels of stabilized beta-catenin."
28409350
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"In addition, kirenol up-regulated the expression of beta-catenin, CCND1, ALP, and ColA1 which were down-regulated by siRNA knockdown of beta-catenin."
25062891
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"It is believed that accumulation of beta-catenin in the cytoplasm favours its translocation to the nucleus as a cofactor for transcription factors of the T-cell factor and lymphoid enhancing factor (TCF/LEF) family and activates the transcription of Wnt and beta-catenin target genes, which are involved in cellular differentiation and proliferation (Giles et al, 2003)."
16479254
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"Finally, we used immunohistochemistry to verify that our LiCl pharmacological approach resulted in beta-catenin stabilization, elevated levels of nuclear beta-catenin accumulation and henceforth increased Wnt and beta-catenin signaling levels (XREF_FIG, XREF_FIG)."
31655130
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"Indeed, using in vitro culture system, we found that macrophage Foxo1 and β-catenin colocalized in the nucleus, and increased nuclear expression of Foxo1 and β-catenin in response to LPS stimulation."
33288903
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"Then, nuclear beta-catenin binds to the transcription factors of the T cell factor and lymphocyte enhancer factor (TCF/LEF) family and promotes the transcription of Wnt and beta-catenin pathway target genes, including cMYC, cyclin D1, survivin, bcl-2, Rac1, Rho, and Cdc42."
32983019
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"Homozygous and heterozygous deletion of beta-catenin at E13.5 reduced beta-catenin expression but did not alter GS or CPSI immunostaining in E15.5 liver."
29426940
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"Thus, the molecular mechanisms of action of the β-catenin inhibitor PRI-724 and β-catenin siRNA seem somehow different, however, this finding might be limited by the fact that β-catenin siRNA caused only a partial decrease of β-catenin protein expression (Figure 9A)."
32033025
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"However, we noted that the level of beta-catenin was not noticeably increased by the beta-catenin vector infection in unstimulated keratinocytes."
21383695
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"Therefore, the membranous cytoplasmic overexpression of beta-catenin in some cases of SeCC may be caused in part by dysregulation of the Wnt and beta-catenin pathway."
26503156
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"Moreover, knockdown of endogenous Peg3 and Pw1 protein using three separate shRNAs increased beta-catenin expression in 293T cells (XREF_FIG F), and knockdown of endogenous Peg3 and Pw1 also increased beta-catenin expression in HeLa cells (data not shown)."
20064927
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"Further, stabilized beta-catenin may induce the expression of Wnt and beta-catenin target genes by interacting with TCF/LEF transcription factors."
27446433
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"We found that mechanical or pharmacological activation of beta-catenin signaling in PDL cells upregulated the expression of beta-catenin target genes."
24021281
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"To further explore the role of beta-catenin, the inhibitor of beta-catenin, XAV-939, was recruited to repress beta-catenin levels."
33173996
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"Restoring c-Met or beta-catenin protein level by MET or CTNNB1 transient overexpression partially restored the malignancy of HCC cells in vitro ."
35518051
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"SNF2H promotes the growth of HCC cells by activating the Wnt and beta-catenin pathway, which increases beta-catenin protein levels and enhances the nuclear accumulation beta-catenin."
27446433
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"We discovered that overexpressing beta-catenin in MSCs clearly upregulated the expression of beta-catenin and c-Myc, whereas repression of beta-catenin significantly suppressed the proliferation related proteins."
32977843
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"Stabilization of beta-catenin in the ureteric cell lineage before the onset of kidney development increased beta-catenin levels and caused renal aplasia or severe hypodysplasia."
21436291
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"They found that interacting beta-catenin with FoxM1 could increase the expression of Wnt and beta-catenin target genes, thus promoting the cell proliferation and growth of gliomas [XREF_BIBR]."
28837560
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"Moreover, knockdown of OPN significantly decreased the protein levels of p-MEK, p-MAPK1, and beta-Catenin, OPN up-regulation distinctly activated the MEK and MAPK pathway and beta-Catenin expression in RBE cells, and this activation of MEK and MAPK pathway was abrogated by MEK inhibitor U0126."
29415992
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"In adenocarcinomas, elevated beta-catenin levels caused by mutations in CTNNB1 or APC result in the activation of the Wnt and beta-catenin pathway."
23784889
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"When the pathway is activated, Wnt inhibits β-catenin phosphorylation, which in turn will increase the levels of unphosphorylated β-catenin in the cytoplasm."
| PMC
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"Finally, knockdown of beta-catenin decreased beta-catenin target gene expression and hIPC proliferation."
18422699
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"Activation of the Wnt / beta-catenin pathway via inhibitors specific to GSK3beta and GSK3alpha increased beta-catenin levels."
26546268
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"Additionally, the Wnt and beta-catenin agonist, CP21, significantly restored the expression of beta-catenin and abilities of migration and invasion in BCL9-knockdown A549 and DDP cell lines."
30009824
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"As shown in XREF_FIG, liposome mediated transduction of plasmid DNA expressing beta-catenin restored the protein expression of beta-catenin in FoxM1 CKO mouse lungs."
20660612
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"The release of beta-catenin from this complex promotes cell motility and causes the level of cytosolic beta-catenin to rise (reviewed by Conacci-Sorrell et al., 2002)."
12408824
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"Our model shows that (1) Pdcd4 knock-down leads to down-regulation of E-cadherin through up-regulating Snail expression, (2) decreased E-cadherin expression changes cell morphology and releases beta-catenin, and (3) the free beta-catenin then translocates into the nucleus, binds to Tcf4 transcription factors, and activates beta-catenin and Tcf dependent transcription to stimulate the expression of u-PAR and c-Myc, which promote tumor cell invasion (XREF_FIG)."
19784072
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"Likewise, small interfering RNA (siRNA) knockdown of beta-catenin in BTSM strips reduced beta-catenin expression and attenuated maximal KCl- and methacholine induced contractions without affecting sm-alpha-actin or sm-MHC expression."
20472712
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"The m6A modification of CTNNB1 promotes the expression of β-catenin and activates the Wnt pathway (Liu L. et al., 2019)."
34277630
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"And most importantly, Wnt and beta-catenin signaling pathway activation by overexpression of beta-catenin not only significantly reversed the anti-proliferation and induction apoptosis of baicalein, but also attenuated the baicalein induced motility restriction, indeed promoting its motile ability."
29156780
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"First, knockdown of beta-catenin by siRNA significantly decreased beta-catenin protein levels in parallel with an increase of E-cadherin and a decrease of vimentin, compared to that in control, suggesting the reverse of EMT (XREF_FIG)."
32606745
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"On the contrary, beta-catenin could eliminate the effect of PFD and enhance the protein levels of beta-catenin, TGF-beta1, TGF-betaRIota, TGF-betaRIotaIota and p-Smad2/3 in cells (P < 0.05, Fig."
32448163
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"We then performed the western blotting and found that this antibody can recognize several β-catenin isoforms and knockdown of circβ-catenin reduced the protein levels of full-length β-catenin and β-catenin-370aa (Fig. 5d)."
31027518
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"Wnt and beta-catenin signaling activation contributes to chemoresistance in OS cells, and increased beta-catenin expression has been correlated with shorter cumulative survival in OS patients XREF_BIBR, XREF_BIBR."
25347326
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"Overexpression of HIF1A-AS2 increased SOX4, MET, C-myc, cyclinD1, Fra-1, VEGF, and β-catenin expressions in renal cells (Figure 5E); knockdown of HIF1A-AS2 decreased SOX4, MET, C-myc, cyclinD1, Fra-1, VEGF, and β-catenin expression in renal carcinomas cells (Figure 5F)."
33710813
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"In Wnt dependent cancers, Wnt pathways are aberrantly activated by mutational mechanisms, including the inactivation of APC or AXIN, or by activating mutations in beta-catenin, all of which lead to constitutive transcription of beta-catenin and TCF-regulated genes [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
30813388
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"Since beta-catenin (CTNNB1) is an important regulator of the Wnt and beta-catenin signaling pathway, and many transcriptional regulators have been shown to regulate the transcription of CTNNB1, nuclear MYH9 induced CTNNB1 transcription in GC cells found in this study further contributed to our understanding of the mechanisms regulating the transcription of CTNNB1."
32685004
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"The aims of this study were to address the distribution of beta-catenin expression in invasive breast cancers, the correlations between beta-catenin expression and clinicopathological features and survival of breast cancer patients, and to determine whether aberrant beta-catenin expression is driven by CTNNB1 (beta-catenin encoding gene) activating mutations."
21076461