IndraLab

Statements

Mutated CTNNB1 increases the amount of CTNNB1. 4 / 4
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"Altogether, the results showed that beta catenin mutations found in HCCs generated by TCPOBOP alone, unlike those observed in HCCs from DENA-TCPOBOP-treated mice, do not induce the transcription of cl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30201494
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"Our data suggest that CTNNB1 mutations that increase beta-catenin protein levels sensitize cells to navitoclax."
23993102
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"Mutation of beta-catenin, APC or Axin found in several human cancers was reported to cause elevated beta-catenin levels and yield inappropriate activation of TCF target genes such as c-Myc and cyclin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19563778
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"Activation of beta-catenin transcription by APC mutations or mutations of beta-catenin itself is not functionally equivalent to an up-regulated Wnt initiated signalling because Wnt activates, except for the canonical beta-catenin pathway another pathway that through kinases Tak1 and Nlk (Nemo like kinase) phosphorylates and inhibits TCF4 [XREF_BIBR] finely tuning transcriptional activity under physiologic conditions."
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