IndraLab

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Modified CTNNB1 increases the amount of CTNNB1. 23 / 23
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"In addition, the expression of beta-catenin target genes, Axin2, was also increased, which supports not only high expression of beta-catenin, but also high activity."
31644894
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"By comparing Fig. 2 and Table 3, it was found that the effects of promoter haplotypes on mRNA expression levels were identical to their effects on asthma risks : Ht1 decreased both beta-catenin mRNA e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22579815
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"HONE1 hybrid cells with infected beta-catenin shRNA have reduced expression of beta-catenin and representative results from various passages of cell populations after infection of shRNA plasmids are shown in the bottom panel, Figure XREF_FIG A. beta-catenin expression was reduced by approximately 54%, 97%, 70%, and 79% in MCH4.5 and MCH4.6 cell lines at different passage levels after infection."
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"On the other hand, overexpression of beta-catenin in shDKK1-transfectants restored the transcription of beta-catenin, and attenuated the inhibitory effect of shDKK1 on invasion."
24325363
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"The translocation of intact beta-catenin to the nucleus, promotes transcription of Wnt and beta-catenin target gene, cyclin D1."
27546592
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"The expression of Wnt7b and beta-catenin in radial arteries was higher in end stage renal disease than in control group, and IS increased Wnt7b and beta-catenin expression in HASMCs as early as 3days after stimulation."
29195902
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"We next investigated the possibility that increased levels of nuclear beta-catenin in the mutant developing cerebral cortex enhance the transcription of Wnt and beta-catenin target genes."
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"The results showed that overexpression of beta-catenin increased beta-catenin level (XREF_FIG), and RNAi decreased beta-catenin expression (XREF_FIG)."
25727520
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"However there were increased levels of p-beta-Catenin and decreased levels of activated-beta-Catenin in old HMDSCs."
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"Moreover, overexpression of LV-beta-catenin in Se-PFPs-treated HEY and SKOV3 cells could rescue the protein expression of beta-catenin to the level similar to untreated control cells."
27058760
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"Our data extend those of previous studies in which conditional pancreas specific disruption of beta-catenin resulted in decreased numbers of beta cells and total islet area at birth [XREF_BIBR], whereas levels of a constitutively activated beta-catenin in beta cells increased nuclear levels of beta-catenin, resulting in increased cyclin D2 levels and beta cell proliferation [XREF_BIBR]."
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"Moreover, miR-152-suppressed beta-catenin expression was reversed by forced expression of beta-catenin."
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"Additionally, compared with the blank and the NC groups, the LINC00968 vector and si-WNT2 groups had decreased levels of beta-catenin, GSK3beta and Vimentin, downregulated phosphorylation levels of beta-catenin and GSK3beta, and elevated level of E-cadherin (all p < 0.05)."
30791958
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"We demonstrate that overexpression of membrane tethered beta-catenin elevates the level of free endogenous beta-catenin, which subsequently accumulates in nuclei."
9314542
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"Consequently, beta-catenin transcription and translation was down-regulated, decreasing beta-catenin levels in the cytoplasm, and ultimately inhibiting the Wnt signaling pathway."
27910912
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"This results in the translocation of beta-Catenin to nucleus, where it interacts with TCF/LEF transcription factors to activate transcription of beta-Catenin regulated genes."
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"Real-time PCR and Western blot assay at 48 h after infection showed that CTNNB1 knockdown in A-498 cells significantly decreased the mRNA and protein levels of CTNNB1 (XREF_FIG), whereas overexpression of CTNNB1 in 786-O (XREF_FIG) and ACHN cells (XREF_SUPPLEMENTARY) significantly increased the mRNA and protein levels of CTNNB1."
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"Bandapalli et al. [XREF_BIBR] reported that overexpression of beta-catenin increases nuclear level of beta-catenin and carcinogenesis including metastasis."
25210229
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"Moreover, overexpression of beta-catenin along with Sox1 greatly enhanced the amount of beta-catenin that was co-immunoprecipitated by the Sox1 antibody, suggesting that Sox1 can bind to beta-catenin [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15110721
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"Second, beta-catenin overexpression in the metanephric mesenchyme leads to elevated levels of transcriptionally active beta-catenin in the ureteric epithelium."
24637293
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"We thus postulated that the increased cytosolic beta-catenin levels with TRIM33 suppression is directly caused by the up-regulation of nuclear beta-catenin levels by TRIM33 suppression."
25639486
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"The lack of known TCF consensus element binding sites in the mouse Ctnnb1 and human CTNNB1 promoter regions currently limits support for the argument that beta-catenin and TCF transcription directly regulates Ctnnb1 transcription, though further studies to address the point will need to be pursued."
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"After induction of IL-1beta, gene expression of Wnt-3a, beta-catenin and MMP-13 were increased, so were the protein expression of beta-catenin and MMP-13."
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