IndraLab

Statements

USP47 affects CDH1
1 | 4
USP47 deubiquitinates CDH1. 5 / 5
1 | 4
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"As mentioned above, E-cadherin is deubiquitinated by USP47."
34604226
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"USP47 can be recruited to AJs and suppress the ubiquitination of E-cadherin, thus inhibiting its resultant proteasomal degradation."
29080116
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"However, as mentioned above, E-cadherin can also be deubiquitinated and stabilized by USP47."
34604226
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
"USP47 can be recruited to AJs and suppress the ubiquitination of E-cadherin, thus inhibiting its resultant proteasomal degradation"
29080116
USP47 affects SNAI1
1 | 2
USP47 deubiquitinates SNAI1. 3 / 3
1 | 2
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"USP47 has been shown to induce the decomposition of E-cadherin and promote the epithelial–mesenchymal transition via Snail-deubiquitination (Choi et al., 2017)."
34604226
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"USP47, which deubiquitinates SNAIL1, is upregulated in hypoxia via a transcription factor cascade."
32470488
ubibrowser
"Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9"
29162839
USP47 affects NLRP3
| 3
USP47 deubiquitinates NLRP3. 3 / 3
| 3
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"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC
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"USP47 reversed the ubiquitination of NLRP3."
35678979
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"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
33414510
USP47 affects RPS2
| 1 1
USP47 deubiquitinates RPS2. 2 / 2
| 1 1
trips
"USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2."
32370049
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"Further mechanistic studies showed that USP47 deubiquitinated RPS2, thereby inhibiting interaction between RPS2 and MDM2, and alleviated RPS2-mediated MDM2 inhibition under normal conditions, thus inhibiting P53."
34604226
USP47 affects POLB
1 | 1
USP47 deubiquitinates POLB. 2 / 2
1 | 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
No evidence text available
USP47 affects CTNNB1
1 | 1
USP47 deubiquitinates CTNNB1. 2 / 2
1 | 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
ubibrowser
"Additionally, DUBs USP14, USP15, USP47, and Fam/USP9X have been reported to prevent β-catenin turnover by inhibiting its Ub-proteasomal degradation"
29080116
USP47 deubiquitinates ubiquitinated ribosomal protein S2. 1 / 1
| 1
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"We show that ubiquitinated ribosomal protein S2 (RPS2) by Mouse double minute 2 homolog (MDM2) is deubiquitinated by USP47."
32370049
USP47 affects katanin-p60 32
| 1
USP47 deubiquitinates katanin-p60 32. 1 / 1
| 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects beta-Trcp 31
| 1
USP47 deubiquitinates beta-Trcp 31. 1 / 1
| 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects YBX1
| 1
Modified USP47 leads to the deubiquitination of YBX1. 1 / 1
| 1
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"XREF_FIG, USP47 overexpression significantly inhibits ubiquitination of full-length YB-1 and YB-1-S3, but not that of the truncated YB-1-S2, which can not bind USP47."
33397955
USP47 affects YB-1-S3
| 1
Modified USP47 leads to the deubiquitination of YB-1-S3. 1 / 1
| 1
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"XREF_FIG, USP47 overexpression significantly inhibits ubiquitination of full-length YB-1 and YB-1-S3, but not that of the truncated YB-1-S2, which can not bind USP47."
33397955
USP47 affects USP47
| 1
USP47 deubiquitinates USP47. 1 / 1
| 1
trips
"Furthermore, USP47 deubiquitinates itself, whereas β-TrCP promotes USP47 ubiquitination through interaction with an atypical motif in USP47."
26169834
USP47 affects SNAIL
| 1
USP47 deubiquitinates SNAIL. 1 / 1
| 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects Polβ
| 1
USP47 deubiquitinates Polβ. 1 / 1
| 1
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"Parsons et al. (2011) found that USP47 could deubiquitinate Polβ, and USP47 knockdown inhibited the base excised repair pathway and increased hydrogen peroxide-induced DNA damage sensitivity."
34604226
USP47 affects Pol beta
| 1
USP47 deubiquitinates Pol beta. 1 / 1
| 1
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"Intriguingly, we discovered that USP47 was able to deubiquitylate both mono- and polyubiquitylated forms of Pol beta in vitro."
25076968
USP47 affects POLL
1 |
USP47 deubiquitinates POLL. 1 / 1
1 |
ubibrowser
"DNA Pol?β?is a component of the BER complex. It is ubiquitinated by Mule and CHIP and is deubiquitinated by USP47?"
25121098
USP47 affects MAPK
| 1
USP47 deubiquitinates MAPK. 1 / 1
| 1
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"Specifically, USP47 deubiquitinates and stabilizes MAPK 25, DNA polymerase beta (Polbeta) 26, E-cadherin 27, beta-catenin 28, SNAIL 29, YAP 30, beta-Trcp 31, and katanin-p60 32."
33397955
USP47 affects Groucho/TLE
| 1
USP47 deubiquitinates Groucho/TLE. 1 / 1
| 1
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"USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling."
36749823