IndraLab

Statements

USP47 deubiquitinates RPS2. 5 / 5
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trips
"USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2."
32370049
reach
"Further mechanistic studies showed that USP47 deubiquitinated RPS2, thereby inhibiting interaction between RPS2 and MDM2, and alleviated RPS2-mediated MDM2 inhibition under normal conditions, thus inhibiting P53."
34604226
reach
"Furthermore, we found that USP47 can function as a regulator of the MDM2-p53 axis by deubiquitinating ribosomal protein S2 (RPS2), e.g., ribosomal stress decreased the interaction between RPb2 and USP47, causing RPS2 to disassociate and inhibit MDM2, which subsequently lead to p53 stabilization."
37740002
reach
"While USP7 stabilizes MDM2 directly, USP47 regulates MDM2 by deubiquitinating RPS2, suggesting that USP47 could be a delicate regulator of p53 in some stress responses."
37740002
reach
"While USP47 and USP7 both regulate the MDM2–p53 pathway, USP7 stabilizes MDM2 directly, while USP47 regulates MDM2 by deubiquitinating RPS2 ."
37740002