IndraLab

Statements

USP47 deubiquitinates NLRP3. 7 / 7
| 7
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"ZNF883 targets miR-138-5p which negatively regulates ubiquitin-specific peptidase 47 (USP47), which reverses the ubiquitination of NLRP3 (Gong et al. 2022)."
40056236
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"A previous study revealed that USP7 and USP47 activated NLRP3 inflammasome by regulating ASC oligomerization, NLRP3 ubiquitination, and speck formation in macrophages, but remained unclear whether USP7 and USP47 contributed to NLRP3 deubiquitination directly or indirectly [32]."
38467635
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"However, it is not clear whether USP7 and USP47 directly contribute to NLRP3 deubiquitination or regulate the process somewhere upstream of NLRP3 inflammasome action [108]."
| PMC
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"Conversely, deubiquitination of NLRP3 by USP7 and USP47 positively regulates inflammasome activation and USP47 is significantly downregulated in dopaminergic neurons from idiopathic PD patient post-mortem brain samples [XREF_BIBR, XREF_BIBR]."
33414510
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"A recent study has found that USP7 and USP47 are involved in the activation of inflammasomes in macrophages and play a direct role in the deubiquitination of NLRP3 [69]."
39767641
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"Both regulate various signaling pathways, such as the inflammasome pathway , WNT signaling , Hedgehog signaling , etc. USP7 and USP47 deubiquitinate NLRP3 and control the assembly and activation of inflammasomes in macrophages ."
37740002
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"USP47 reversed the ubiquitination of NLRP3."
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