IndraLab

Statements

PSMD14 affects E2F1
| 8
PSMD14 deubiquitinates E2F1. 8 / 8
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"This finding led us to hypothesize that POH1 may interact with and deubiquitinate E2F1."
26510456
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"Our present study provides evidence that POH1 deubiquitinates and stabilizes the master transcription factor E2F1 and functions as a tumour promoting protein in HCCs."
26510456
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"We propose that the deubiquitination of E2F1 by POH1 primarily occurs in the nucleus; as a consequence, the prosurvival genes, including Survivin and FOXM1, are transcriptionally activated."
26510456
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"POH1 knockdown significantly enhanced the levels of E2F1 ubiquitination (XREF_FIG)."
26510456
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"We demonstrated that POH1 efficiently deubiquitinates E2F1 by removing the K-63 polyubiquitin chains, and this observation is consistent with previous studies revealing that the JAMM domain within POH1 is responsible for removing K63 linked ubiquitin chains XREF_BIBR XREF_BIBR XREF_BIBR."
26510456
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"In addition, in MG132 treated cells, wherein the global proteasomal activity was inhibited, ectopic POH1 expression was able to deubiquitinate E2F1 (XREF_SUPPLEMENTARY), suggesting that this effect is independent of the overall proteasome function."
26510456
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"Of note, although E2F1 deubiquitination by POH1 has been revealed to be important for E2F1 stabilization, the molecular details of the regulation remain to be defined."
26510456
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"In line with our results, a previous study revealed that POH1, a deubiquitinase, binds to and deubiquitinates E2F1, contributing to its stabilization."
33816295
PSMD14 affects TGFBR
| 2
PSMD14 deubiquitinates TGFBR. 2 / 2
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"Mechanistically, POH1 deubiquitinates the TGF-beta receptors and CAV1, therefore negatively regulates lysosome pathway mediated turnover of TGF-beta receptors."
30745168
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"In hepatocellular carcinoma, PSMD14 enhanced the activation of TGF-beta signaling and tumor metastasis by deubiquitinating TGF-beta receptors and caveolin-1 XREF_BIBR."
33897885
PSMD14 affects TGFB
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PSMD14 deubiquitinates TGFB. 2 / 2
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"In hepatocellular carcinoma, PSMD14 enhanced the activation of TGF-beta signaling and tumor metastasis by deubiquitinating TGF-beta receptors and caveolin-1 XREF_BIBR."
33897885
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"Mechanistically, POH1 deubiquitinates the TGF-beta receptors and CAV1, therefore negatively regulates lysosome pathway mediated turnover of TGF-beta receptors."
30745168
PSMD14 affects JUN
| 2
Modified PSMD14 leads to the deubiquitination of JUN. 2 / 2
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"Ectopic expression of POH1 in HEK293 cells decreased the level of c-Jun ubiquitination, leading to significant accumulation of the protein and a corresponding increase in AP1 mediated gene expression."
16569633
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"A previous study indicated that POH1 overexpression in HEK293 cells downregulates c-Jun ubiquitination, resulting in c-Jun accumulation and upregulation of AP1 mediated gene expression XREF_BIBR."
26510456
PSMD14 affects ERBB2
1 | 1
PSMD14 deubiquitinates ERBB2. 2 / 2
1 | 1
ubibrowser
"POH1 regulates ErbB2, an EGFR family member"
25121098
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"We propose that POH1 may deubiquitinate ErbB2 and that this activity is not necessarily coupled to proteasomal degradation."
19436748
PSMD14 affects CAV1
| 2
PSMD14 deubiquitinates CAV1. 2 / 2
| 2
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"Mechanistically, POH1 deubiquitinates the TGF-beta receptors and CAV1, therefore negatively regulates lysosome pathway mediated turnover of TGF-beta receptors."
30745168
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"In hepatocellular carcinoma, PSMD14 enhanced the activation of TGF-beta signaling and tumor metastasis by deubiquitinating TGF-beta receptors and caveolin-1 XREF_BIBR."
33897885
PSMD14 affects specific deubiquitinating enzyme
| 1
PSMD14 deubiquitinates specific deubiquitinating enzyme on K63. 1 / 1
| 1
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"Second, proteasomal Poh1 possesses a K63 specific deubiquitinating enzyme activity, which is required for activating aggresome clearance (XREF_FIG)."
24035499
PSMD14 affects proIL‐1β
| 1
PSMD14 deubiquitinates proIL‐1β. 1 / 1
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"In line with this work, Zhang et al.81 have shown that POH1, a DUB that forms part of the 19S subunit of the proteasome, interacts with and deubiquitinates proIL‐1β by decreasing the K63‐linked polyubiquitin chains, as well as decreasing the efficacy of proIL‐1β cleavage."
31679183
PSMD14 affects pro-IL-1β
| 1
PSMD14 deubiquitinates pro-IL-1β. 1 / 1
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"POH1 deubiquitinates pro-IL-1β and inhibits mature IL-1β production, thus restricting inflammasome activity and LPS-induced inflammation [93]."
32650621
PSMD14 affects bortezomib
| 1
PSMD14 leads to the deubiquitination of bortezomib. 1 / 1
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"Together with the finding that POH1 inhibition induced a distinctly different change in the ubiquitination profile from bortezomib, this compound may have potential as a treatment modality in patients previously treated with bortezomib."
29134486
PSMD14 affects TRIM21
| 1
PSMD14 deubiquitinates TRIM21. 1 / 1
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"Concurrently, with proteasome-mediated degradation, Poh1 de-ubiquitinates TRIM21 [12]."
28829373
PSMD14 affects SNAIL
| 1
PSMD14 deubiquitinates SNAIL. 1 / 1
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"In ESCC, PSMD14 deubiquitinates and stabilizes SNAIL to promote tumor metastasis XREF_BIBR."
33897885
PSMD14 affects SNAI1
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PSMD14 deubiquitinates SNAI1. 1 / 1
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ubibrowser
"Furthermore, knockdown of PSMD14 significantly blocks SNAIL-induced EMT and then suppresses tumor cell migration and invasion in vitro and tumor metastasis in vivo."
29331416
PSMD14 affects RNF8
| 1
PSMD14 leads to the deubiquitination of RNF8. 1 / 1
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"These findings are consistent with the previous conclusion that POH1 activity antagonizes RNF8 and RNF168 dependent ubiquitylation and restricts 53BP1 foci size."
24013561
PSMD14 affects RNF168
| 1
PSMD14 leads to the deubiquitination of RNF168. 1 / 1
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"These findings are consistent with the previous conclusion that POH1 activity antagonizes RNF8 and RNF168 dependent ubiquitylation and restricts 53BP1 foci size."
24013561
PSMD14 affects Proteasome
| 1
PSMD14 deubiquitinates Proteasome. 1 / 1
| 1
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"It is also speculated that DSF inhibits POH1, a protein which plays an important role in deubiquitinating function of the proteasome lid rather than the actual core proteasome (Chen et al., 2006; Cvek and Dvorak, 2007; Gallery et al., 2007; Yu et al., 2007; Cvek et al., 2008; Yoshino et al., 2020)."
34604310
PSMD14 affects PTBP1
| 1
PSMD14 deubiquitinates PTBP1. 1 / 1
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"PSMD14 was revealed to promote the deubiquitination and stabilization of PTBP1, and PTBP1 knockdown reversed the effects caused by PSMD14 overexpression on cell function."
35405117
PSMD14 affects POU5F1
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PSMD14 deubiquitinates POU5F1. 1 / 1
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PSMD14 affects IL1B
| 1
PSMD14 deubiquitinates IL1B. 1 / 1
| 1
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"In addition, IL-1beta is also deubiquitinated by POH1 inhibiting its cleavage by caspase-1 [XREF_BIBR]."
33432113
PSMD14 affects GRB2
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PSMD14 deubiquitinates GRB2. 1 / 1
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ubibrowser
"PSMD14 inhibits degradation of GRB2 via deubiquitinating this oncoprotein in HCC cells."
31634528
PSMD14 affects EGFR
| 1
PSMD14 deubiquitinates EGFR. 1 / 1
| 1
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"It is also possible that POH1 may de-ubiquitinate EGFR under steady-state conditions, in which case the receptor will be rescued from degradation in the lysosomal pathway."
19436748