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PSMD14 deubiquitinates SNAI1. 8 / 8
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"Furthermore, knockdown of <span class="match term0">PSMD14</span> significantly blocks <span class="match term1">SNAIL</span>-induced EMT and then suppresses tumor cell migration and invasion in vitro and tumor metastasis in vivo."
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"For example, PSMD14 could deubiquitinate snail protein and promote esophageal cancer cell EMT (Epithelial Mesenchymal Transition) [24, 27]."
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"Intriguingly, in cancer cells Snail is deubiquitinated and stabilized by PSMD14 [ 44 ]."
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"In this study, we found that the deubiquitination and stabilization of SNAIL mediated by PSMD14 have a dramatic contribution to promote tumor metastasis both in vitro and in vivo ."
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"Meanwhile, the overexpression of PSMD14 could decrease endogenous SNAIL ubiquitination ( Fig. 3 E)."
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"Deubiquitinases (DUBs) also play an important role in the regulation of Snail1 protein stability, including USP3, USP11, USP13, DUB3, USP18, USP26, USP27X, USP37, USP47, OTUB1, and PSMD14, that have been shown to facilitate deubiquitination and stabilization of nuclear Snail1 in promoting cell proliferation, migration, and invasion ."
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"We would like to investigate such inhibitors for PSMD14 in future work and make efforts for searching effective therapy for particular patients.In summary, this study reveals that SNAIL is one of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Such as, the snail is deubiquitinated and stabilized by PSMD14, DUB3, and USP26 [29–31]."
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