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PSMD14 deubiquitinates TGFBR. 10 / 10
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"Taken together, this study demonstrates that POH1 deubiquitinates the TGF-β receptors and CAV1 to attenuate lysosomal degradation of the receptors, thereby promoting TGF-β signaling and HCC metastasis (Fig. 6e).4 Discussion."
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"PSMD14 also influences HCC metastasis by deubiquitinating the TGF-β receptor and caveolin-1 [28]."
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"POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1."
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"Additionally, PSMD14 enhances metastatic capacity of HCC cells by deubiquitinating TGF-β receptors and caveolin 1 (CAV1), as well as negatively regulating the turnover of TGF-β receptors [ 31 ]."
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"Another study conducted by Wang et al. (2019) demonstrated that down-regulation of PSMD14 decreased caveolin-1-mediated lysosomal degradation of TGFBR1 and TGFBR2 by deubiquitinating the TGF-β receptor."
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"Mechanistically, POH1 deubiquitinates the TGF-beta receptors and CAV1, therefore negatively regulates lysosome pathway-mediated turnover of TGF-beta receptors."
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"Another interesting report demonstrated that POH1 could deubiquitinate TGF-β receptors and repress the degradation of TGF-β receptors in HCC cells, whereas Smad3 protein was unaffected [ 43 ]."
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"Interestingly, PSMD14 could deubiquitinate TGF-β receptors and CAV1, and subsequently suppress lysosome pathway-mediated turnover of TGF-β receptors in HCC cells, which is critical for TGF-β signaling[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, PSMD14 deubiquitinates the TGF-β receptor and caveolin-1 to facilitate HCC metastasis [27]."
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"In hepatocellular carcinoma, PSMD14 enhanced the activation of TGF-beta signaling and tumor metastasis by deubiquitinating TGF-beta receptors and caveolin-1 XREF_BIBR."
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