IndraLab

Statements

PSMD14 deubiquitinates E2F1. 8 / 8
| 8
reach
"This finding led us to hypothesize that POH1 may interact with and deubiquitinate E2F1."
26510456
reach
"Our present study provides evidence that POH1 deubiquitinates and stabilizes the master transcription factor E2F1 and functions as a tumour promoting protein in HCCs."
26510456
reach
"We propose that the deubiquitination of E2F1 by POH1 primarily occurs in the nucleus; as a consequence, the prosurvival genes, including Survivin and FOXM1, are transcriptionally activated."
26510456
reach
"POH1 knockdown significantly enhanced the levels of E2F1 ubiquitination (XREF_FIG)."
26510456
reach
"We demonstrated that POH1 efficiently deubiquitinates E2F1 by removing the K-63 polyubiquitin chains, and this observation is consistent with previous studies revealing that the JAMM domain within POH1 is responsible for removing K63 linked ubiquitin chains XREF_BIBR XREF_BIBR XREF_BIBR."
26510456
reach
"In addition, in MG132 treated cells, wherein the global proteasomal activity was inhibited, ectopic POH1 expression was able to deubiquitinate E2F1 (XREF_SUPPLEMENTARY), suggesting that this effect is independent of the overall proteasome function."
26510456
reach
"Of note, although E2F1 deubiquitination by POH1 has been revealed to be important for E2F1 stabilization, the molecular details of the regulation remain to be defined."
26510456
reach
"In line with our results, a previous study revealed that POH1, a deubiquitinase, binds to and deubiquitinates E2F1, contributing to its stabilization."
33816295