IndraLab

Statements

USP41 affects SNAI1
| 19 4
USP41 binds SNAI1.
| 4 4
USP41 binds SNAI1. 8 / 8
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"USP41 Interacts with and Deubiquitinates Snail."
36675208
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"Since DUBs regulate various cellular processes by interacting with target proteins [28], we examined the interaction between USP41 and Snail."
36675208
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"USP41 interacts with Snail and stabilizes Snail via deubiquitination."
36675208
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"In mechanisms, USP41 bound to Snail, a master regulator of EMT, and induced Snail deubiquitination, thereby increasing the stabilization of Snail."
36675208
sparser
"Since DUBs regulate various cellular processes by interacting with target proteins [ xref ], we examined the interaction between USP41 and Snail."
36675208
sparser
"Therefore, these results indicated that USP41 interacts with Snail resulting in the induction of Snail destabilization."
36675208
sparser
"USP41 interacts with Snail and stabilizes Snail via deubiquitination."
36675208
sparser
"In mechanisms, USP41 bound to Snail, a master regulator of EMT, and induced Snail deubiquitination, thereby increasing the stabilization of Snail."
36675208
USP41 ubiquitinates SNAI1.
| 3
USP41 leads to the ubiquitination of SNAI1. 3 / 3
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"Moreover, siRNA-mediated USP41 downregulation increased the ubiquitination of Snail in both breast cancer cells (Figure 5B), whereas overexpression of USP41 decreased Snail ubiquitination (Figure 5C)."
36675208
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"Collectively, these results suggest that Snail ubiquitination is modulated by the expression levels of USP41 and TRIM21."
36675208
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"Therefore, we supposed that the balance of USP41 and TRIM21 may modulate the ubiquitination and stabilization of Snail."
36675208
USP41 deubiquitinates SNAI1.
| 3
USP41 deubiquitinates SNAI1. 3 / 3
| 3
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"Moreover, siRNA-mediated USP41 downregulation increased the ubiquitination of Snail in both breast cancer cells (Figure 5B), whereas overexpression of USP41 decreased Snail ubiquitination (Figure 5C)."
36675208
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"Furthermore, USP41 interacted with and inhibited ubiquitination of Snail, resulting in the increase in Snail stabilization."
36675208
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"USP41 Interacts with and Deubiquitinates Snail."
36675208
USP41 activates SNAI1.
| 3
USP41 activates SNAI1. 2 / 2
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"USP41-mediated Snail stabilization plays a critical role in EMT and metastasis, and provides a crucial target against breast cancer therapy."
36675208
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"Next, we investigated the USP41-mediated Snail protein stability using cycloheximide (CHX; protein synthesis inhibitor)."
36675208
USP41 bound to SNAI1 activates SNAI1. 1 / 1
| 1
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"In mechanisms, USP41 bound to Snail, a master regulator of EMT, and induced Snail deubiquitination, thereby increasing the stabilization of Snail."
36675208
USP41 inhibits SNAI1.
| 2
USP41 inhibits SNAI1. 2 / 2
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"As shown in Figure 4F, MG132 inhibited USP41 siRNA-induced Snail downregulation in MDA-MB-231 and MDA-MB-361 cells."
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"Knockdown of TRIM21 markedly rescued Snail downregulation by USP41 siRNA in both breast cancer cells."
36675208
USP41 increases the amount of SNAI1.
| 2
USP41 increases the amount of SNAI1. 2 / 2
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"In addition, depletion of USP41 downregulated Snail protein expression, an epithelial-mesenchymal transition marker, but not mRNA expression."
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"In addition, ectopic expression of USP41 upregulated Snail protein expression (Figure 4C)."
36675208
USP41 decreases the amount of SNAI1.
| 2
USP41 decreases the amount of SNAI1. 2 / 2
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"Downregulation of USP41 only decreased the protein level of Snail (Figure 4A,B), as a transcription repressor in the EMT process, whereas other EMT-related proteins (E-cadherin, Vimentin and Slug) were not altered (Figure 4A)."
36675208
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"In our study, knockdown or overexpression of USP41 induced the downregulation or upregulation of Snail protein expression in breast cancer cells, respectively (Figure 4A–C)."
36675208
USP41 activates cell population proliferation. 10 / 12
| 12
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"As shown in Figure 3, knockdown of USP41 suppressed the proliferation of MCF-7 and MDA-MB-231 cells (Figure 3A,3C)."
34790772
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"Our study suggested that USP41 knockdown inhibits proliferation and invasive ability of breast cancer cells."
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"It has been reported that USP41 promotes proliferation of lung cancer cells , as well as in other cancerous cell lines, through regulating the deubiquitination of the receptor for activated C kinase 1 (RACK1) and the epithelial-mesenchymal transition transcription factor (EMT-TF) Snail ."
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"In contrast, the overexpression of USP41 significantly enhanced the proliferation of MCF-7 cells and MDA-MB-231 cells (Figure 3B,3D)."
34790772
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"Likewise, the ectopic expression of Snail prevented the USP41 siRNA-mediated reduction of cancer cell proliferation, while knockdown of Snail inhibits proliferation by USP41 overexpression (Figure 6G,H)."
36675208
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"Overexpression of USP41 greatly enhanced BC colony-forming ability, proliferation, and migration."
34790772
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"In vitro experiments further revealed that the knockdown of ABHD12 and USP41 significantly inhibit the proliferation, invasion and migration of breast cancer cells."
36993976
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"Other study revealed that USP41 knockdown inhibited cell proliferation, cell migration, and increased cell apoptosis in lung cancer (Ji et al. 2021)."
37212877
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"In contrast, USP41 knockdown significantly inhibited BC colony-forming ability, proliferation, and migration."
34790772
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"Knockdown of USP41 Inhibits Migration and Proliferation of Breast Cancer Cells."
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"Interestingly, drug sensitivity analysis with IC50 further suggested that docetaxel, epirubicin and inhibitors of PI3K/AKT/mTOR signaling pathway (afuresertib, buparlisib, ipatasertib and dactolisib) are more beneficial to patients in the low-risk group, whereas tyrosine kinase inhibitors (ibrutinib, lapatinib and sapitinib) may better benefit patients in the high-risk group ( Supplementary Figure S6 ).3.9 Sponging ABHD12 and USP41 significantly inhibited the proliferation, invasion and migration of breast cancer cells."
36993976
USP41 affects NPPA
| 10
NPPA binds USP41. 10 / 10
| 10
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"An in vitro disintegration test was performed following the general disintegration testing procedure as per USP41-NF36."
34775042
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"The drug content of the prepared lornoxicam DT was found to be within the pharmacopoeial guidelines (USP41-NF36) requirement."
36558914
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"The X-SSG is available in different types and grades, differing in their degrees of substitution, sodium content, pH value, crosslink density, and swelling capacity ( JRS, 2019; Shah and Augsburger, 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31394182
sparser
"The friability testing was performed on 6.5 g equivalent number of randomly picked tablets (USP41-NF36)."
36493968
sparser
"This might be attributed to the lower sodium glycolate content of this grade (2.0–3.4%) compared to the regular and CLV grades (2.8–4.2%) ( USP41-NF36, 2019a )."
31394182
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"Sodium starch glycolate may contain up to 7.0% sodium chloride ( USP41-NF36, 2019a )."
31394182
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"Explotab® Low pH has a lower percentage of sodium (2.0–3.4% versus 2.8–4.2%), exhibiting a lower pH value (3.0–5.0 versus 5.5–7.5) ( USP41-NF36, 2019a )."
31394182
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"The results of % drug available in the dissolution media ( Table 6 ) showed values within the USP acceptance criteria, as per different monographs of opioid drugs ( USP41-NF36, 2019c, 2019d, 2019e, 20[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31394182
sparser
"The results were within the USP limits specified for different opioid drug products ( USP41-NF36, 2019b, 2019c, 2019d, 2019e, 2019f )."
31953084
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"The following solutions were prepared and used in this study: 0.1 N hydrochloric acid (8.3 mL of HCl 37% adjusted to 1 L with distilled water), pH 3 solution (distilled water adjusted to pH 3 with HCl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31394182
SNAI1 affects USP41
| 5 4
SNAI1 binds USP41.
| 4 4
USP41 binds SNAI1. 8 / 8
| 4 4
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"USP41 Interacts with and Deubiquitinates Snail."
36675208
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"Since DUBs regulate various cellular processes by interacting with target proteins [28], we examined the interaction between USP41 and Snail."
36675208
reach
"USP41 interacts with Snail and stabilizes Snail via deubiquitination."
36675208
reach
"In mechanisms, USP41 bound to Snail, a master regulator of EMT, and induced Snail deubiquitination, thereby increasing the stabilization of Snail."
36675208
sparser
"Since DUBs regulate various cellular processes by interacting with target proteins [ xref ], we examined the interaction between USP41 and Snail."
36675208
sparser
"Therefore, these results indicated that USP41 interacts with Snail resulting in the induction of Snail destabilization."
36675208
sparser
"USP41 interacts with Snail and stabilizes Snail via deubiquitination."
36675208
sparser
"In mechanisms, USP41 bound to Snail, a master regulator of EMT, and induced Snail deubiquitination, thereby increasing the stabilization of Snail."
36675208
SNAI1 activates USP41.
| 1
SNAI1 activates USP41. 1 / 1
| 1
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"Likewise, the ectopic expression of Snail prevented the USP41 siRNA-mediated reduction of cancer cell proliferation, while knockdown of Snail inhibits proliferation by USP41 overexpression (Figure 6G,H)."
36675208
USP41 affects RACK1
| 5 3
USP41 binds RACK1.
| 3
USP41 binds RACK1. 3 / 3
| 3
sparser
"The Co-IP results indicated that USP41 could interact with RACK1 ( xref )."
34790772
sparser
"USP41 interacted with RACK1 in BC cells."
34790772
sparser
"Moreover, Co-Immunoprecipitation mass spectrometry results indicated that USP41 could interact with RACK1 ."
34790772
USP41 activates RACK1.
| 3
USP41 activates RACK1. 3 / 3
| 3
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"Thus, USP41 promoted BC function through upregulating RACK1."
34790772
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"Since function of RACK1 is diverse and extensive in breast cancer, they mentioned that the investigation of the roles of USP41-mediated RACK1 in cancer cell migration are necessary."
36675208
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"Previously, Huang et al. identified the RACK1 as a novel protein interacting with USP41 through CoIP-MS analysis and indicated the promotion of migration via USP41-induced RACK1 upregulation [25]."
36675208
USP41 increases the amount of RACK1.
| 2
USP41 increases the amount of RACK1. 2 / 2
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"Immunoblotting results showed that USP41 promoted the protein expression of RACK1 (Figure 6B)."
34790772
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"USP41 promoted the protein expression of RACK1."
34790772
USP41 activates Neoplasm Invasiveness.
| 5
USP41 activates Neoplasm Invasiveness. 5 / 5
| 5
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"We found that USP41 upregulation enhanced the growth, proliferation, and invasion of BC cells."
34790772
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"Meanwhile, the overexpression of USP41 enhanced cell invasion in MCF-7 cells (Figure 4C)."
34790772
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"In vitro experiments further revealed that the knockdown of ABHD12 and USP41 significantly inhibit the proliferation, invasion and migration of breast cancer cells."
36993976
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"Ectopic expression of USP41 promoted cell migration and invasion in MDA-MB-231 and MDA-MB-361 cells (Figure 3B,C)."
36675208
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"Together, these data suggest that USP41 overexpression could enhance the growth and invasion of breast cancer cells."
36675208
USP41 inhibits Neoplasm Invasiveness. 1 / 1
| 1
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"Interestingly, drug sensitivity analysis with IC50 further suggested that docetaxel, epirubicin and inhibitors of PI3K/AKT/mTOR signaling pathway (afuresertib, buparlisib, ipatasertib and dactolisib) are more beneficial to patients in the low-risk group, whereas tyrosine kinase inhibitors (ibrutinib, lapatinib and sapitinib) may better benefit patients in the high-risk group ( Supplementary Figure S6 ).3.9 Sponging ABHD12 and USP41 significantly inhibited the proliferation, invasion and migration of breast cancer cells."
36993976
USP41P affects USP18
4 | 1
USP18 binds USP41P. 5 / 5
4 | 1
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
sparser
"Here, we show that USP18 interacts with its paralog USP41, whose catalytic domain shares 97% identity with USP18."
38853827
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
eidos
"USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer ."
33619866
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"Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration."
33619866
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"MTT, EdU, flow cytometry, and transwell assays further determined that USP41 enhanced the proliferation and migration of lung cancer cells."
33619866
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"USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer."
33619866
USP41 affects UBD
| 4
USP41 inhibits UBD.
| 2
USP41 inhibits UBD. 2 / 2
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"Finally, we propose that USP41 antagonizes conjugation of the understudied ubiquitin-like protein FAT10 (HLA-F adjacent transcript 10) from substrates in a catalytic-independent manner."
38853827
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"Based on our data and the AlphaFold prediction, it is tempting to speculate that USP41 might be sequestering FAT10 away from its conjugation machinery, leading to decreased levels of FAT10 conjugation, but this will require additional investigation.Finally, it is notable that over the course of our study, USP41 went from being annotated as a protein-coding gene in databases to now being a pseudogene."
38853827
USP41 binds UBD.
| 2
USP41 binds UBD. 2 / 2
| 2
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"We first assessed binding between USP41 and FAT10 by co-immunoprecipitation experiment."
38853827
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"Again, we took advantage of AlphaFold to generate the structure of USP41 bound to FAT10, where we highlighted the catalytic triad of the DUB as well as FAT10 Gly165, which gets conjugated to substrates (Figure 6C)."
38853827
RACK1 affects USP41
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RACK1 binds USP41.
| 3
USP41 binds RACK1. 3 / 3
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sparser
"The Co-IP results indicated that USP41 could interact with RACK1 ( xref )."
34790772
sparser
"USP41 interacted with RACK1 in BC cells."
34790772
sparser
"Moreover, Co-Immunoprecipitation mass spectrometry results indicated that USP41 could interact with RACK1 ."
34790772
RACK1 inhibits USP41.
| 1
RACK1 inhibits USP41. 1 / 1
| 1
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"Knockdown of RACK1 inhibited cell growth and migration, and reversed the oncogenic function of USP41 in BC cells."
34790772
USP41 affects cell migration
| 3
USP41 activates cell migration. 3 / 3
| 3
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"Ectopic expression of USP41 promoted cell migration and invasion in MDA-MB-231 and MDA-MB-361 cells (Figure 3B,C)."
36675208
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"Identically, USP41 overexpression promoted cell migration in MDA-MB-231 cell line (Figure 4D)."
34790772
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"Other study revealed that USP41 knockdown inhibited cell proliferation, cell migration, and increased cell apoptosis in lung cancer (Ji et al. 2021)."
37212877
Indometacin affects USP41P
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Indometacin increases the amount of USP41P.
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Indometacin increases the amount of USP41P. 1 / 1
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ctd
No evidence text available
28628672
Indometacin decreases the amount of USP41P.
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Indometacin decreases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28628672
Hsa-miR-628-3p affects USP41
| 2
Hsa-miR-628-3p inhibits USP41. 2 / 2
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"We also selected TLR3 and MDA5, receptors of double-stranded RNA as same as RIG-I, and TNFSF13B, AIM2, USP41, STAP1, GBP4, CCL8, and IFI27 that had been reported to be down-regulated by the hsa-miR-628-3p mimic (Ueta et al., 2021b)."
36685889
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"TNFSF13B, AIM2, USP41, STAP1, GBP4, CCL8, and IFI27, reportedly down-regulated by the hsa-miR-628-3p mimic, were also significantly up-regulated in the transfected cells."
36685889
Dexamethasone affects USP41P
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Dexamethasone increases the amount of USP41P.
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Dexamethasone increases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28628672
Dexamethasone decreases the amount of USP41P.
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Dexamethasone decreases the amount of USP41P. 1 / 1
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ctd
No evidence text available
28628672
Bisphenol A affects USP41P
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Bisphenol A increases the amount of USP41P. 2 / 2
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ctd
No evidence text available
28628672
ctd
No evidence text available
29275510
USP41P affects migration
| 2
USP41P activates migration. 2 / 2
| 2
eidos
"USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer ."
33619866
eidos
"In contrast , USP41 knockdown significantly inhibited BC colony-forming ability , proliferation , and migration ."
34790772
reach
"USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer."
33619866
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"USP41 knockdown promotes lung cancer cell apoptosis."
33619866
USP41P affects RACK1
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USP41P binds RACK1. 2 / 2
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biogrid
No evidence text available
34790772
biogrid
No evidence text available
34790772
USP41 activates epithelial to mesenchymal transition. 2 / 2
| 2
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"To verify the involvement of Snail in USP41-mediated EMT regulation, we executed the overexpression of Snail in USP41-depleted cells."
36675208
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"USP41 Enhances Epithelial-Mesenchymal Transition of Breast Cancer Cells through Snail Stabilization."
36675208
USP41 affects apoptotic process
| 2
USP41 inhibits apoptotic process.
| 1
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"As shown in Figure 5A,5B, knockdown of USP41 enhanced cell apoptosis in MCF-7 and MDA-MB-231 cells."
34790772
USP41 activates apoptotic process.
| 1
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"Other study revealed that USP41 knockdown inhibited cell proliferation, cell migration, and increased cell apoptosis in lung cancer (Ji et al. 2021)."
37212877
USP41 affects USP18
| 2
USP41 binds USP18.
| 1
USP41 binds USP18. 1 / 1
| 1
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"USP41 bound to USP18, and importantly, this binding occurs through their respective USP domains (Figure 1G and Supplementary Figure 1D)."
38853827
USP41 activates USP18.
| 1
USP41 activates USP18. 1 / 1
| 1
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"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects TRIM21
| 1 1
USP41 binds TRIM21. 2 / 2
| 1 1
sparser
"Moreover, we found the interaction of USP41 and TRIM21 through Snail IP assay using USP41 antibody ( xref E)."
36675208
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"Moreover, we found the interaction of USP41 and TRIM21 through Snail IP assay using USP41 antibody (Figure 5E)."
36675208
USP41 affects ISG15
| 2
ISG15 binds USP41. 2 / 2
| 2
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"While both databases reported several identical ISG15-interacting proteins such as UBA7, the E1 for ISG15, or several members of the IFNA family of proteins (such as IFNA1, IFNA2, INFA8, IFNA10, IFNA14), neither database reported an interaction between ISG15 and USP41."
38853827
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"Finally, we examined whether USP41 could bind ISG15, since USP18 non-covalently interacts with ISG15."
38853827
USP18 affects USP41
| 2
USP18 binds USP41.
| 1
USP41 binds USP18. 1 / 1
| 1
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"USP41 bound to USP18, and importantly, this binding occurs through their respective USP domains (Figure 1G and Supplementary Figure 1D)."
38853827
USP18 activates USP41.
| 1
USP18 activates USP41. 1 / 1
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"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
UBD affects USP41
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USP41 binds UBD. 2 / 2
| 2
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"We first assessed binding between USP41 and FAT10 by co-immunoprecipitation experiment."
38853827
reach
"Again, we took advantage of AlphaFold to generate the structure of USP41 bound to FAT10, where we highlighted the catalytic triad of the DUB as well as FAT10 Gly165, which gets conjugated to substrates (Figure 6C)."
38853827
TRIM21 affects USP41
| 1 1
USP41 binds TRIM21. 2 / 2
| 1 1
sparser
"Moreover, we found the interaction of USP41 and TRIM21 through Snail IP assay using USP41 antibody ( xref E)."
36675208
reach
"Moreover, we found the interaction of USP41 and TRIM21 through Snail IP assay using USP41 antibody (Figure 5E)."
36675208
RACK1 affects USP41P
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USP41P binds RACK1. 2 / 2
2 |
biogrid
No evidence text available
34790772
biogrid
No evidence text available
34790772
OGT affects USP41
| 1 1
OGT binds USP41.
| 1
USP41 binds OGT. 1 / 1
| 1
sparser
"Mechanically, USP41 interacted with OGT in MDA-MB-231 cells."
39923575
OGT activates USP41.
| 1
OGT activates USP41. 1 / 1
| 1
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"Overexpression of OGT enhanced the protein stability of USP41."
39923575
ISG15 affects USP41
| 2
ISG15 binds USP41. 2 / 2
| 2
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"While both databases reported several identical ISG15-interacting proteins such as UBA7, the E1 for ISG15, or several members of the IFNA family of proteins (such as IFNA1, IFNA2, INFA8, IFNA10, IFNA14), neither database reported an interaction between ISG15 and USP41."
38853827
reach
"Finally, we examined whether USP41 could bind ISG15, since USP18 non-covalently interacts with ISG15."
38853827
3-isobutyl-1-methyl-7H-xanthine increases the amount of USP41P.
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3-isobutyl-1-methyl-7H-xanthine increases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28628672
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP41P.
1 |
3-isobutyl-1-methyl-7H-xanthine decreases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28628672
Urethane affects USP41P
1 |
Urethane decreases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28818685
ctd
No evidence text available
26179874
Transferase affects USP41
| 1
sparser
"The interaction between USP41 and O-linked N-acetylglucosamine transferase (OGT) was evaluated by co-immunoprecipitation assay."
39923575
Lipopolysaccharide activates USP41P. 1 / 1
| 1
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"An independent cohort confirmed LPS induction of USP41 and IL10 genes."
27434537
Let-7a-5p affects USP41
| 1
Let-7a-5p activates USP41. 1 / 1
| 1
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"Elsewhere , we reported that let-7a-5p could positively regulate STAP1, IFI44L, CXCL11, TNFSF10, AIM2, RSAD2, IFITM1, CXCL10, CCL8, TRIM22, HERC5, IFI27, IFIT2, GBP4, IFIT1, TNFSF13B, and USP41; genes that were negatively regulated by the miR-628-3p mimic."
39762541
Doxorubicin affects USP41P
1 |
Doxorubicin decreases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
29803840
Bis(2-ethylhexyl) phthalate increases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
31163220
ZBTB16 affects USP41
| 1
ZBTB16 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41P affects protein RACK1
| 1
USP41P activates protein RACK1. 1 / 1
| 1
eidos
"USP41 promoted the protein expression of RACK1 ."
34790772
USP41P affects migration A549 H1299 cells
| 1
USP41P inhibits migration A549 H1299 cells. 1 / 1
| 1
eidos
"Transwell assay further demonstrated that USP41 knockdown increased the migration rate of A549 and H1299 cells ."
33619866
USP41P affects messenger RNA
| 1
USP41P activates messenger RNA. 1 / 1
| 1
eidos
"In addition , depletion of USP41 downregulated Snail protein expression , an epithelial-mesenchymal transition marker , but not mRNA expression ."
36675208
USP41P activates epithelial to mesenchymal transition. 1 / 1
| 1
reach
"We knocked down E-cadherin in lung cancer cell lines using siRNA, and demonstrated that E-Cadherin knockout offseted the effect of inhibition of USP41 on cell migration, and inhibition of USP41 may reverse EMT of lung cancer cells."
33619866
USP41P affects cell migration
| 1
USP41P activates cell migration. 1 / 1
| 1
reach
"These results indicated that USP41 promoted lung cancer cell migration."
33619866
USP41P affects cell apoptosis lung cancer
| 1
USP41P inhibits cell apoptosis lung cancer. 1 / 1
| 1
eidos
"USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer ."
33619866
USP41P affects Osteosarcoma
| 1
USP41P inhibits Osteosarcoma. 1 / 1
| 1
reach
"Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619."
34571917
USP41P affects Breast Neoplasms
| 1
eidos
"USP41 promotes breast cancer via regulating RACK1 ."
34790772
USP41P affects BC colony-forming
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USP41P activates BC colony-forming. 1 / 1
| 1
eidos
"In contrast , USP41 knockdown significantly inhibited BC colony-forming ability , proliferation , and migration ."
34790772
USP41 affects wound healing
| 1
USP41 activates wound healing. 1 / 1
| 1
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"Knockdown of USP41 suppressed wound healing activity and migration in two breast cancer cells (Figure 2B,C)."
36675208
USP41 affects transferase
| 1
sparser
"The interaction between USP41 and O-linked N-acetylglucosamine transferase (OGT) was evaluated by co-immunoprecipitation assay."
39923575
reach
"USP41 contributes to invasion, apoptosis and drug resistance in breast and lung cancer cells."
36675208
USP41 affects conjugation
| 1
USP41 inhibits conjugation. 1 / 1
| 1
reach
"Finally, we propose that USP41 antagonizes conjugation of the understudied ubiquitin-like protein FAT10 (HLA-F adjacent transcript 10) from substrates in a catalytic-independent manner."
38853827
USP41 affects cell growth
| 1
USP41 activates cell growth. 1 / 1
| 1
reach
"Knockdown of USP41 inhibited migration and growth of breast cancer cells, whereas overexpression of USP41 increased cell growth and migration."
36675208
USP41 affects ZBTB16
| 1
USP41 activates ZBTB16. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects UBASH3B
| 1
USP41 activates UBASH3B. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects STAG3
| 1
USP41 activates STAG3. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects SPATS2L
| 1
USP41 activates SPATS2L. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects RSAD2
| 1
USP41 activates RSAD2. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects RGS13
| 1
USP41 activates RGS13. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects OGT
| 1
USP41 binds OGT. 1 / 1
| 1
sparser
"Mechanically, USP41 interacted with OGT in MDA-MB-231 cells."
39923575
USP41 affects OAS3
| 1
USP41 activates OAS3. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects ILI27
| 1
USP41 activates ILI27. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects IL1R2
| 1
USP41 activates IL1R2. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects IFI44L
| 1
USP41 activates IFI44L. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects FKBP5
| 1
USP41 activates FKBP5. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects FERIL14
| 1
USP41 activates FERIL14. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41 affects CDH1
| 1
USP41 activates CDH1. 1 / 1
| 1
reach
"Previously, Ji et al. reported that shRNA-mediated USP41 knockout suppresses migration via E-cadherin upregulation in lung adenocarcinoma [26]."
36675208
USP41 affects BC
| 1
USP41 activates BC. 1 / 1
| 1
reach
"Overexpression of USP41 greatly enhanced BC colony-forming ability, proliferation, and migration."
34790772
reach
"Previously, Ji et al. reported that shRNA-mediated USP41 knockout suppresses migration via E-cadherin upregulation in lung adenocarcinoma [26]."
36675208
UBASH3B affects USP41
| 1
UBASH3B activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
STAG3 affects USP41
| 1
STAG3 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
SPATS2L affects USP41
| 1
SPATS2L activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
RSAD2 affects USP41
| 1
RSAD2 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
RGS13 affects USP41
| 1
RGS13 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
PM affects USP41
| 1
PM inhibits USP41. 1 / 1
| 1
reach
"In summary, PM inhibited cell viability, proliferation, and migration of BC by regulating the O-GlcNAcylation of USP41."
39923575
OAS3 affects USP41
| 1
OAS3 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
USP41P is modified
| 1
USP41P is deubiquitinated. 1 / 1
| 1
trips
"Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration."
33619866
Neoplasms affects USP41
| 1
Neoplasms increases the amount of USP41. 1 / 1
| 1
reach
"Tumor tissues of breast cancer patients were overexpressed USP41 expression and had shorter survival time than patients with low expression of USP41 (Figure 1C,D)."
36675208
ILI27 affects USP41
| 1
ILI27 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
IL1R2 affects USP41
| 1
IL1R2 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
IFNA affects USP41P
1 |
IFNA increases the amount of USP41P. 1 / 1
1 |
bel
"Table 3. Genes on chromosome 22 exhibiting IFN-sensitive expression changes"
16319195
IFI44L affects USP41
| 1
IFI44L activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
FKBP5 affects USP41
| 1
FKBP5 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
FERIL14 affects USP41
| 1
FERIL14 activates USP41. 1 / 1
| 1
reach
"OAS3, RGS13, STAG3, IFI44L, STS-1, FERIL14, ZBTB16, USP18, USP41, RSAD2, FKBP5, IL1R2, DNAPTP6 and ILI27, which top 14 significantly upregulated mRNAs in SLE patients compared with Healthy donors, sho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923569
4,4'-sulfonyldiphenol decreases the amount of USP41P. 1 / 1
1 |
ctd
No evidence text available
28628672