IndraLab

Statements

USP41 inhibits UBD. 2 / 2
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"Finally, we propose that USP41 antagonizes conjugation of the understudied ubiquitin-like protein FAT10 (HLA-F adjacent transcript 10) from substrates in a catalytic-independent manner."
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"Based on our data and the AlphaFold prediction, it is tempting to speculate that USP41 might be sequestering FAT10 away from its conjugation machinery, leading to decreased levels of FAT10 conjugation, but this will require additional investigation.Finally, it is notable that over the course of our study, USP41 went from being annotated as a protein-coding gene in databases to now being a pseudogene."
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