IndraLab

Statements

MPND binds Histone. 8 / 8

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"Moreover, the DNA and the two acidic regions of MPND synergistically enhance the interaction between MPND and histones."

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"The DNA and two acidic regions of MPND synergistically enhance the interaction between MPND and histones."

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"Direct Histone Binding by MPND and Cooperative Regulation by Acidic Regions and DNA."

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"Due to the fact that the positive residues are rich in histone tails, we hypothesize that the MPND may also bind to histones directly."

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"As shown in Figure 6, MPND also bound histones, thereby indicating that the lone MPN domain of MPND interacted with histones directly.Prompted by these findings, we further examined the impact of dsDNA on MPND-binding histones."

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"In summary, MPND binds directly to histones."

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"Moreover, the two acidic regions promoted the binding of MPND to histones."

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"These findings suggest that MPND may be related to histone ubiquitination, thus indicating a previously unrecognized form of gene control and transcriptional regulation.Together, our results provide the first structural insights into the MPND–DNA complex and evidence of the direct interactions between MPND and histones."

36834777

Bisphenol A affects MPND

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Bisphenol A increases the amount of MPND.

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Bisphenol A increases the amount of MPND. 2 / 2

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ctd

No evidence text available

33221593

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ctd

No evidence text available

32156529

Bisphenol A methylates MPND.

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Bisphenol A methylates MPND. 1 / 1

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ctd

No evidence text available

28505145

MPND affects diphosphate(4-)

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MPND activates diphosphate(4-). 3 / 3

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"Interestingly, both TleC and MpnD also accepted farnesyl pyrophosphate (FPP) (C 15), geranylgeranyl pyrophosphate (GGPP) (C 20) and geranylfarnesyl pyrophosphate (GFPP) (C 25) as prenyl donors, to produce 5, 6 and 7, respectively (XREF_FIG and XREF_SUPPLEMENTARY)."

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"In contrast to typical indole PTs that exhibit broad substrate specificities towards the prenyl acceptors but with strict specificities towards the prenyl donors XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR, it is remarkable that the indolactam specific TleC and MpnD exhibited unusually relaxed substrate specificities towards the prenyl donors and accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."

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"Interestingly, the indolactam specific TleC and MpnD both accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."

26952246

MPND affects E7

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MPND binds E7. 3 / 3

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virhostnet

No evidence text available

28786561

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biogrid

No evidence text available

28786561

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biogrid

No evidence text available

28786561

Valproic acid affects MPND

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Valproic acid methylates MPND.

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Valproic acid methylates MPND. 1 / 1

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ctd

No evidence text available

29154799

Valproic acid decreases the amount of MPND.

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Valproic acid decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

15901671

Thioacetamide affects MPND

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Thioacetamide decreases the amount of MPND. 2 / 2

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ctd

No evidence text available

23411599

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ctd

No evidence text available

34492290

Benzo[a]pyrene affects MPND

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Benzo[a]pyrene decreases the amount of MPND. 2 / 2

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ctd

No evidence text available

32234424

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ctd

No evidence text available

20106945

TleC affects MPND

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MPND binds TleC. 2 / 2

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"Furthermore, the crystal structures of TleC and MpnD complexed with the substrates suggested that the distance between the C-3 position of DMSPP and the C-7 position of 1 (3.3 A in TleC and 3.1 A in MpnD) is closer than that between the C-1 position of the prenyl substrates and the N-1 position of 1 (6.0 A in TleC and MpnD) (XREF_SUPPLEMENTARY)."

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"The structural analysis of MpnD and TleC complexed with substrates suggested that the three amino acid residues Trp97, Phe170, and Ala173 in TleC and Tyr80, Trp157, and Met159 in MpnD regulate the selectivity of the length of prenyl donor and regiospecificity of prenylation position."

32180104

MPND is modified

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MPND is phosphorylated on S181. 1 / 1

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hprd

No evidence text available

17081983

MPND is phosphorylated on S178. 1 / 1

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hprd

No evidence text available

17081983

MPND affects prenyl diphosphate

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MPND activates prenyl diphosphate. 2 / 2

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"First, the indolactam specific TleC and MpnD both accepted DMAPP (C 5) and GPP (C 10) as substrates to produce pendolmycin (3), and lyngbyatoxin A (2) and 5-geranylindolactam V (4) (2:4 = 26:1 for TleC; 2:4 = 1:3 for MpnD), respectively (XREF_FIG)."

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"Thus, TleC and MpnD clearly prefer to accept GPP and DMAPP as the prenyl donors, respectively."

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MPND affects TleC

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MPND binds TleC. 2 / 2

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32180104

MPND affects DEG15

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MPND activates DEG15. 2 / 2

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"Thus, TleC and MpnD clearly prefer to accept GPP and DMAPP as the prenyl donors, respectively."

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2,3,7,8-tetrachlorodibenzodioxine affects MPND

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2,3,7,8-tetrachlorodibenzodioxine decreases the amount of MPND. 2 / 2

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ctd

No evidence text available

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ctd

No evidence text available

26290441

Trichostatin A affects MPND

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Trichostatin A decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

15901671

Trichloroethene affects MPND

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Trichloroethene decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

33387578

Tetrachloroethene affects MPND

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Tetrachloroethene decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

28973375

Sulforaphane affects MPND

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Sulforaphane decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

31838189

Sorafenib affects MPND

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Sorafenib increases the amount of MPND. 1 / 1

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ctd

No evidence text available

39786591

Saxitoxin affects MPND

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Saxitoxin decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

39571800

Pregnenolone 16alpha-carbonitrile affects MPND

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Pregnenolone 16alpha-carbonitrile increases the amount of MPND. 1 / 1

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ctd

No evidence text available

28903501

Perfluorooctane-1-sulfonic acid affects MPND

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Perfluorooctane-1-sulfonic acid decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

36331819

Methylmercury chloride affects MPND

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Methylmercury chloride decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

28001369

Methapyrilene affects MPND

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Methapyrilene demethylates MPND. 1 / 1

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ctd

No evidence text available

30157460

Jinfukang affects MPND

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Jinfukang increases the amount of MPND. 1 / 1

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ctd

No evidence text available

27392435

Hsa-miR-335-5p affects MPND

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Hsa-miR-335-5p decreases the amount of MPND. 1 / 1

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biopax:mirtarbase

No evidence text available

18185580

Hsa-let-7b-5p affects MPND

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Hsa-let-7b-5p decreases the amount of MPND. 1 / 1

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biopax:mirtarbase

No evidence text available

23622248

Hexabromocyclododecane affects MPND

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Hexabromocyclododecane decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

29177809

Genistein affects MPND

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Genistein increases the amount of MPND. 1 / 1

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ctd

No evidence text available

18847459

Folic acid affects MPND

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Folic acid decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

22206623

Double-stranded DNA affects MPND

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MPND binds double-stranded DNA. 1 / 1

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"Earlier research suggested that the MPND binds to double-stranded DNA (dsDNA) containing 6mA modifications in vitro [9]."

36834777

Deoxynivalenol affects MPND

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Deoxynivalenol decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

35307453

Cyclosporin A affects MPND

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Cyclosporin A decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

20106945

Copper(II) sulfate affects MPND

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Copper(II) sulfate decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

19549813

Copper atom affects MPND

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Copper atom increases the amount of MPND. 1 / 1

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ctd

No evidence text available

30556269

Cobalt dichloride affects MPND

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Cobalt dichloride decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

24386269

Clofibrate affects MPND

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Clofibrate decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

23811191

Bis(2-ethylhexyl) phthalate affects MPND

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Bis(2-ethylhexyl) phthalate increases the amount of MPND. 1 / 1

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ctd

No evidence text available

33754040

Beta-lapachone affects MPND

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Beta-lapachone decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

38218311

Beta-D-glucose affects MPND

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Beta-D-glucose decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

36331819

Benzo[e]pyrene affects MPND

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Benzo[e]pyrene demethylates MPND. 1 / 1

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ctd

No evidence text available

30157460

Atrazine affects MPND

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Atrazine decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

22378314

Aristolochic acid A affects MPND

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Aristolochic acid A decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

33212167

Aflatoxin B1 affects MPND

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Aflatoxin B1 decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

27153756

Abrine affects MPND

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Abrine decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

31054353

USP36 affects MPND

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USP36 binds MPND. 1 / 1

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biogrid

No evidence text available

19615732

USP30 affects MPND

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USP30 binds MPND. 1 / 1

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biogrid

No evidence text available

19615732

UBXN7 affects MPND

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UBXN7 binds MPND. 1 / 1

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biogrid

No evidence text available

37024974

TERF2IP affects MPND

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TERF2IP binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

TBX5 affects MPND

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TBX5 binds MPND. 1 / 1

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biogrid

No evidence text available

35182466

Smoke affects MPND

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Smoke decreases the amount of MPND. 1 / 1

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ctd

No evidence text available

34520756

QPRT affects MPND

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QPRT binds MPND. 1 / 1

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biogrid

No evidence text available

33961781

Particulate Matter affects MPND

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Particulate Matter increases the amount of MPND. 1 / 1

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ctd

No evidence text available

35964746

POLR1G affects MPND

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POLR1G binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

PARP1 affects MPND

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PARP1 binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

Nitrates affects MPND

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Nitrates increases the amount of MPND. 1 / 1

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ctd

No evidence text available

35964746

MPND affects tumor penetration

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MPND activates tumor penetration. 1 / 1

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eidos

"Furthermore , using multicellular tumor spheroids to mimic in vivo experiment , MPND can enhance the tumor penetration and therapeutic effect for killing the deep tumor tissue at the central location ."

35007003

MPND affects pathogenesis

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MPND activates pathogenesis. 1 / 1

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"We observed an overlap between nAMD/(iAMD) and MPNd in immunological markers that differed between the MPNs with and without drusen, supporting that these specific changes could be a part of drusen/AMD pathogenesis."

36200281

MPND affects pPAJV643

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MPND activates pPAJV643. 1 / 1

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"The mpnD gene encodes a prenyltransferase that , unlike TleC or LtxC , transfers a dimethylallyl group to the C-7 position of ILV to complete the biosynthesis of pendolmycin.7 Like the verification of tleC above , mpnD was cloned into the position of ltxC to create pPAJV643 ( ltxAB-mpnD ) ."

31846576

MPND affects migration breast cancer cells

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MPND inhibits migration breast cancer cells. 1 / 1

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"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."

35423422

MPND affects double-stranded DNA

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MPND binds double-stranded DNA. 1 / 1

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"Earlier research suggested that the MPND binds to double-stranded DNA (dsDNA) containing 6mA modifications in vitro [9]."

36834777

MPND affects cellular uptake

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MPND activates cellular uptake. 1 / 1

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"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."

35423422

MPND affects active proteins

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MPND activates active proteins. 1 / 1

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"These results show that the codon-optimized tleC , tleD , and mpnD all produce active proteins with the expected activity when heterologously expressed in Anabaena 7120.9 , 15 This demonstrates that the native levels of transcriptional and translational regulation exerted when these genes occupy the same positions as ltxC ( tleC , mpnD ) and ltxD ( tleD ) in the ltx gene cluster are sufficient to produce proteins that efficiently catalyzed the desired reactions ; each protein completely converted its substrate to the expected product ( s ) because 1 was not observed in extracts of ltxABC-tleD or ltxAB-mpnD ."

31846576

MPND affects USP36

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USP36 binds MPND. 1 / 1

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biogrid

No evidence text available

19615732

MPND affects USP30

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USP30 binds MPND. 1 / 1

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biogrid

No evidence text available

19615732

MPND affects UBXN7

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UBXN7 binds MPND. 1 / 1

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biogrid

No evidence text available

37024974

MPND affects Therapeutics

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MPND activates Therapeutics. 1 / 1

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eidos

35007003

MPND affects TERF2IP

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TERF2IP binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

MPND affects TBX5

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TBX5 binds MPND. 1 / 1

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biogrid

No evidence text available

35182466

MPND affects QPRT

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QPRT binds MPND. 1 / 1

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biogrid

No evidence text available

33961781

MPND affects POLR1G

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POLR1G binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

MPND affects PARP1

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PARP1 binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

MPND affects Neoplasms

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MPND activates Neoplasms. 1 / 1

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"Furthermore, using multicellular tumor spheroids to mimic in vivo experiment, MPND can enhance the tumor penetration and therapeutic effect for killing the deep tumor tissue at the central location."

35007003

MPND affects MECP2

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MECP2 binds MPND. 1 / 1

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biogrid

No evidence text available

38697112

MPND affects DOX

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MPND decreases the amount of DOX. 1 / 1

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"When the MPND is internalized into the cancer cell, the rupture of -S-S- bridges and the degradation of MPND occur in the tumor microenvironment with a high level of GSH, inducing the on-demand release of DOX."

35007003

MPND affects DLG4

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DLG4 binds MPND. 1 / 1

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biogrid

No evidence text available

21653829

MPND affects COIL

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COIL binds MPND. 1 / 1

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biogrid

No evidence text available

34079125

MPND affects C5

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MPND activates C5. 1 / 1

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"This would be the reason why MpnD produces not only the C-7 ' reverse ' prenylation product 2 but also the C-5 ' normal ' prenylation product 4."

26952246

MPND affects Biological Availability

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MPND activates Biological Availability. 1 / 1

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eidos

"Results showed that MPND causes enhanced bioavailability , better cellular uptake , and inhibition of the migration of breast cancer cells as compared to the drug alone ."

35423422