IndraLab

Statements

MPND binds Histone. 8 / 8
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"Moreover, the DNA and the two acidic regions of MPND synergistically enhance the interaction between MPND and histones."
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"The DNA and two acidic regions of MPND synergistically enhance the interaction between MPND and histones."
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"Direct Histone Binding by MPND and Cooperative Regulation by Acidic Regions and DNA."
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"Due to the fact that the positive residues are rich in histone tails, we hypothesize that the MPND may also bind to histones directly."
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"As shown in Figure 6, MPND also bound histones, thereby indicating that the lone MPN domain of MPND interacted with histones directly.Prompted by these findings, we further examined the impact of dsDNA on MPND-binding histones."
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"In summary, MPND binds directly to histones."
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"Moreover, the two acidic regions promoted the binding of MPND to histones."
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"These findings suggest that MPND may be related to histone ubiquitination, thus indicating a previously unrecognized form of gene control and transcriptional regulation.Together, our results provide the first structural insights into the MPND–DNA complex and evidence of the direct interactions between MPND and histones."
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