IndraLab

Statements



reach
"Interestingly, the indolactam specific TleC and MpnD both accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."

reach
"In contrast to typical indole PTs that exhibit broad substrate specificities towards the prenyl acceptors but with strict specificities towards the prenyl donors XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR, it is remarkable that the indolactam specific TleC and MpnD exhibited unusually relaxed substrate specificities towards the prenyl donors and accepted different chain lengths (from C 5 to C 25) of prenyl pyrophosphate in vitro."

reach
"Interestingly, both TleC and MpnD also accepted farnesyl pyrophosphate (FPP) (C 15), geranylgeranyl pyrophosphate (GGPP) (C 20) and geranylfarnesyl pyrophosphate (GFPP) (C 25) as prenyl donors, to produce 5, 6 and 7, respectively (XREF_FIG and XREF_SUPPLEMENTARY)."