IndraLab

Statements

eidos
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation , invasive metastasis , and EMT ."
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"In contrast, the knockdown MINDY2 group significantly inhibited PC cell liver metastasis in vivo ( Figure 5C )."
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"Thus, MINDY2 promoted PC growth and liver metastasis in vivo.2.5 MINDY2 interacts with ACTN4 and stabilizes ACTN4 by deubiquitination function."
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"To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed ( Figures 7A–C )."
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"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
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"We found that the expression level of MINDY2 was elevated in PC."
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eidos
"The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K / AKT / mTOR signaling pathway ."
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"Moreover, the Kaplan-Meier analysis of survival demonstrated that the overall survival of patients with high MINDY2 expression was considerably lower than that of the control group ( Figure 3D ).2.3 MINDY2 promotes PC cell proliferation, invasion, and migration in vitro ."
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"MINDY2 stabilized ACTN4 expression and then promoted the growth and metastasis of PC [36]."
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"In light of the preceding findings, MINDY2 may increase the invasion and metastasis of PC cells via EMT.2.4 MINDY2 promotes PC growth and liver metastasis in vivo ."
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UBC affects MINDY2
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UBC binds MINDY2. 6 / 6
6 |
biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
34529927
Bisphenol A affects MINDY2
5 |
Bisphenol A decreases the amount of MINDY2.
3 |
Bisphenol A decreases the amount of MINDY2. 3 / 3
3 |
ctd
No evidence text available
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ctd
No evidence text available
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ctd
No evidence text available
34947998
Bisphenol A increases the amount of MINDY2.
2 |
Bisphenol A increases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
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ctd
No evidence text available
25181051
MINDY2 affects Neoplasm Metastasis
| 1 4
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"In light of the preceding findings, MINDY2 may increase the invasion and metastasis of PC cells via EMT.2.4 MINDY2 promotes PC growth and liver metastasis in vivo ."
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"In contrast, the knockdown MINDY2 group significantly inhibited PC cell liver metastasis in vivo ( Figure 5C )."
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"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
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eidos
"The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K / AKT / mTOR signaling pathway ."
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"MINDY2 stabilized ACTN4 expression and then promoted the growth and metastasis of PC [36]."
39907925
Titanium dioxide affects MINDY2
4 |
Titanium dioxide methylates MINDY2.
2 |
ctd
No evidence text available
35295148
ctd
No evidence text available
34973136
Titanium dioxide demethylates MINDY2.
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Titanium dioxide demethylates MINDY2. 1 / 1
1 |
ctd
No evidence text available
35295148
Titanium dioxide decreases the amount of MINDY2.
1 |
Titanium dioxide decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
30012374
Particulate Matter increases the amount of MINDY2.
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Particulate Matter increases the amount of MINDY2. 2 / 2
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ctd
No evidence text available
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ctd
No evidence text available
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Particulate Matter decreases the amount of MINDY2.
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Particulate Matter decreases the amount of MINDY2. 2 / 2
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ctd
No evidence text available
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ctd
No evidence text available
34057650
MINDY2 affects ACTN4
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MINDY2 increases the amount of ACTN4.
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MINDY2 increases the amount of ACTN4. 1 / 1
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"The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K/AKT/mTOR signaling pathway."
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MINDY2 deubiquitinates ACTN4.
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MINDY2 deubiquitinates ACTN4. 1 / 1
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"MINDY Lysine 48 Deubiquitinase 2 (MINDY2) interacts with and deubiquitinates ACTN4, stabilizes ACTN4, and activates the PI3K/AKT/mTOR signaling pathway to promote pancreatic cancer proliferation and metastasis [20]."
39115875
MINDY2 decreases the amount of ACTN4.
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MINDY2 decreases the amount of ACTN4. 1 / 1
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"Ubiquitination experiments showed that over-expression of MINDY2 markedly decreased the ubiquitination level of ACTN4; at the same time, the level of ACTN4 ubiquitination was significantly higher after MINDY2 downregulation ( Figures 6H, I )."
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MINDY2 activates ACTN4.
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MINDY2 activates ACTN4. 1 / 1
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"Thus, MINDY2 promoted PC growth and liver metastasis in vivo.2.5 MINDY2 interacts with ACTN4 and stabilizes ACTN4 by deubiquitination function."
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ACTN4 affects MINDY2
| 4
ACTN4 activates MINDY2.
| 3
ACTN4 activates MINDY2. 3 / 3
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"Therefore, we conducted a series of cell biology tests after silencing ACTN4 in PC cells overexpressing MINDY2 and discovered that silencing ACTN4 reversed the pro-carcinogenic role of MINDY2 in PC."
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"Also, it was found that the knockdown of ACTN4 reduced the ability of MINDY2 to promote EMT ( Figure 7E ); both the Transwell test and the wound healing experiment demonstrated that MINDY2’s capacity to encourage PC cell invasion and migration was significantly reduced ( Figures 7F, G )."
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"First, we found that the half-life of ACTN4 was significantly prolonged after treating cells overexpressing MINDY2 with CHX, and the half-life of ACTN4 was shortened after silencing MINDY2.Furthermore, the regulatory effect of MINDY2 on ACTN4 protein disappeared after the addition of MG132-treated cells."
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ACTN4 inhibits MINDY2.
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ACTN4 inhibits MINDY2. 1 / 1
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"Therefore, we conducted a series of cell biology tests after silencing ACTN4 in PC cells overexpressing MINDY2 and discovered that silencing ACTN4 reversed the pro-carcinogenic role of MINDY2 in PC."
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Valproic acid affects MINDY2
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Valproic acid increases the amount of MINDY2.
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Valproic acid increases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
21427059
ctd
No evidence text available
19136453
Valproic acid decreases the amount of MINDY2.
1 |
Valproic acid decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
26272509
Sodium arsenite affects MINDY2
3 |
Sodium arsenite decreases the amount of MINDY2.
2 |
Sodium arsenite decreases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
34032870
ctd
No evidence text available
28595984
Sodium arsenite increases the amount of MINDY2.
1 |
Sodium arsenite increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
38568856
Pirinixic acid affects MINDY2
3 |
Pirinixic acid decreases the amount of MINDY2.
2 |
Pirinixic acid decreases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
23811191
ctd
No evidence text available
19710929
Pirinixic acid activates MINDY2.
1 |
ctd
No evidence text available
19710929
USP22 affects MINDY2
3 |
MINDY2 binds USP22. 3 / 3
3 |
biogrid
No evidence text available
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No evidence text available
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No evidence text available
26186194
SLC2A8 affects MINDY2
3 |
MINDY2 binds SLC2A8. 3 / 3
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No evidence text available
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No evidence text available
28514442
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No evidence text available
33961781
SLC27A2 affects MINDY2
3 |
biogrid
No evidence text available
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biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
SCCPDH affects MINDY2
3 |
MINDY2 binds SCCPDH. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
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biogrid
No evidence text available
28514442
RETSAT affects MINDY2
3 |
MINDY2 binds RETSAT. 3 / 3
3 |
biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
33961781
PTRH2 affects MINDY2
3 |
MINDY2 binds PTRH2. 3 / 3
3 |
biogrid
No evidence text available
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biogrid
No evidence text available
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biogrid
No evidence text available
28514442
PRAF2 affects MINDY2
3 |
MINDY2 binds PRAF2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
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biogrid
No evidence text available
33961781
PPM1B affects MINDY2
3 |
MINDY2 binds PPM1B. 3 / 3
3 |
biogrid
No evidence text available
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biogrid
No evidence text available
26186194
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No evidence text available
28514442
MINDY2 is modified
3 |
MINDY2 is phosphorylated on S94. 3 / 3
3 |
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
hprd
No evidence text available
18669648
MINDY2 activates cell population proliferation. 3 / 3
| 3
reach
"Moreover, the Kaplan-Meier analysis of survival demonstrated that the overall survival of patients with high MINDY2 expression was considerably lower than that of the control group ( Figure 3D ).2.3 MINDY2 promotes PC cell proliferation, invasion, and migration in vitro ."
37207150
reach
"To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed ( Figures 7A–C )."
37207150
reach
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
37207150
MINDY2 affects USP22
3 |
MINDY2 binds USP22. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY2 affects SLC2A8
3 |
MINDY2 binds SLC2A8. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
MINDY2 affects SLC27A2
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
MINDY2 affects SCCPDH
3 |
MINDY2 binds SCCPDH. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects RETSAT
3 |
MINDY2 binds RETSAT. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
MINDY2 affects PTRH2
3 |
MINDY2 binds PTRH2. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects PRAF2
3 |
MINDY2 binds PRAF2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
MINDY2 affects PPM1B
3 |
MINDY2 binds PPM1B. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects MBLAC2
3 |
MINDY2 binds MBLAC2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
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biogrid
No evidence text available
33961781
MINDY2 affects KCNJ11
3 |
KCNJ11 binds MINDY2. 3 / 3
3 |
biogrid
No evidence text available
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biogrid
No evidence text available
33961781
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No evidence text available
28514442
MINDY2 affects GNPAT
3 |
MINDY2 binds GNPAT. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY2 affects DNAJC1
3 |
MINDY2 binds DNAJC1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
MINDY2 affects CYP2J2
3 |
MINDY2 binds CYP2J2. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects ARL13B
3 |
MINDY2 binds ARL13B. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
MBLAC2 affects MINDY2
3 |
MINDY2 binds MBLAC2. 3 / 3
3 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
KCNJ11 affects MINDY2
3 |
KCNJ11 binds MINDY2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
GNPAT affects MINDY2
3 |
MINDY2 binds GNPAT. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
DNAJC1 affects MINDY2
3 |
MINDY2 binds DNAJC1. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
CYP2J2 affects MINDY2
3 |
MINDY2 binds CYP2J2. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ARL13B affects MINDY2
3 |
MINDY2 binds ARL13B. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
Bisphenol F affects MINDY2
2 |
Bisphenol F increases the amount of MINDY2.
1 |
Bisphenol F increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
38685157
Bisphenol F decreases the amount of MINDY2.
1 |
Bisphenol F decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
36041667
XXYLT1 affects MINDY2
2 |
MINDY2 binds XXYLT1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
Vehicle Emissions increases the amount of MINDY2.
1 |
Vehicle Emissions increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
34057650
Vehicle Emissions decreases the amount of MINDY2.
1 |
Vehicle Emissions decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
34057650
S-(1,2-dichlorovinyl)-L-cysteine increases the amount of MINDY2.
1 |
S-(1,2-dichlorovinyl)-L-cysteine increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
35811015
S-(1,2-dichlorovinyl)-L-cysteine decreases the amount of MINDY2.
1 |
S-(1,2-dichlorovinyl)-L-cysteine decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
35811015
Nanotubes, Carbon decreases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
25620056
ctd
No evidence text available
25554681
MINDY2 activates signal transduction. 2 / 2
| 2
reach
"Thus, ACTN4 is crucial in the activation of the PI3K/AKT/mTOR signaling pathway by MINDY2."
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reach
"Bioinformatics Analysis and Western blot experiments further confirmed that MINDY2 stabilizes ACTN4 through deubiquitination and thus activates the PI3K/AKT/mTOR signaling pathway."
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MINDY2 activates epithelial to mesenchymal transition. 2 / 2
| 1 1
reach
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
37207150
eidos
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation , invasive metastasis , and EMT ."
37207150
MINDY2 affects XXYLT1
2 |
MINDY2 binds XXYLT1. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects PI3K/AKT/mTOR
| 2
MINDY2 activates PI3K/AKT/mTOR. 2 / 2
| 2
reach
"Thus, ACTN4 is crucial in the activation of the PI3K/AKT/mTOR signaling pathway by MINDY2."
37207150
reach
"Bioinformatics Analysis and Western blot experiments further confirmed that MINDY2 stabilizes ACTN4 through deubiquitination and thus activates the PI3K/AKT/mTOR signaling pathway."
37207150
MINDY2 affects ARL8B
2 |
MINDY2 binds ARL8B. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
MINDY2 affects ALG11
2 |
MINDY2 binds ALG11. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
Lipopolysaccharides increases the amount of MINDY2.
1 |
Lipopolysaccharides increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
35811015
Lipopolysaccharides decreases the amount of MINDY2.
1 |
Lipopolysaccharides decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
35811015
LY294002 affects MINDY2
| 2
LY294002 activates MINDY2. 2 / 2
| 2
reach
"In addition, Western blot found that the phosphorylation levels of PI3K, AKT, and mTOR were increased after MINDY2 overexpression without significant changes in protein levels, and the addition of PI3K inhibitor LY294002 reversed this function of MINDY2; a similar effect was obtained after silencing ACTN4."
37207150
reach
"In contrast, the phosphorylation level was significantly increased, and the addition of PI3K inhibitor LY294002 reversed this function of MINDY2, A similar effect was obtained after silencing ACTN4 ( Figure 7I )."
37207150
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"In addition, Western blot found that the phosphorylation levels of PI3K, AKT, and mTOR were increased after MINDY2 overexpression without significant changes in protein levels, and the addition of PI3K inhibitor LY294002 reversed this function of MINDY2; a similar effect was obtained after silencing ACTN4."
37207150
reach
"In contrast, the phosphorylation level was significantly increased, and the addition of PI3K inhibitor LY294002 reversed this function of MINDY2, A similar effect was obtained after silencing ACTN4 ( Figure 7I )."
37207150
Air Pollutants affects MINDY2
2 |
Air Pollutants increases the amount of MINDY2.
1 |
Air Pollutants increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
37586242
Air Pollutants decreases the amount of MINDY2.
1 |
Air Pollutants decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
37586242
ARL8B affects MINDY2
2 |
MINDY2 binds ARL8B. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ALG11 affects MINDY2
2 |
MINDY2 binds ALG11. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
4,4'-sulfonyldiphenol decreases the amount of MINDY2. 2 / 2
2 |
ctd
No evidence text available
36041667
ctd
No evidence text available
39298647
Urethane affects MINDY2
1 |
Urethane increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
28818685
Troglitazone affects MINDY2
1 |
Troglitazone decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
28973697
Triphenyl phosphate increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
30589522
Thiram affects MINDY2
1 |
Thiram increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
38568856
Tetrachloroethene increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
28973375
Succimer affects MINDY2
1 |
Succimer decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
21641980
Sodium arsenate affects MINDY2
1 |
Sodium arsenate increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
21795629
Resveratrol affects MINDY2
1 |
Resveratrol increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
23557933
Propiconazole affects MINDY2
1 |
Propiconazole decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
21278054
Phenobarbital affects MINDY2
1 |
Phenobarbital decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
23091169
Paraquat affects MINDY2
1 |
Paraquat decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
32680482
Miconazole affects MINDY2
1 |
Miconazole decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
27462272
Methylmercury chloride decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
28001369
Methamphetamine affects MINDY2
1 |
Methamphetamine increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
19564919
Magnetite nanoparticle decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
21641980
Hydrogen peroxide decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
26846883
Hsa-mir-4438 affects MINDY2
1 |
Hsa-mir-4438 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-mir-4425 affects MINDY2
1 |
Hsa-mir-4425 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-mir-4252 affects MINDY2
1 |
Hsa-mir-4252 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-mir-3185 affects MINDY2
1 |
Hsa-mir-3185 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-mir-3147 affects MINDY2
1 |
Hsa-mir-3147 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-769-3p affects MINDY2
1 |
Hsa-miR-769-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-7151-3p affects MINDY2
1 |
Hsa-miR-7151-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-7-5p affects MINDY2
1 |
Hsa-miR-7-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6851-3p affects MINDY2
1 |
Hsa-miR-6851-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6832-5p affects MINDY2
1 |
Hsa-miR-6832-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6823-5p affects MINDY2
1 |
Hsa-miR-6823-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6759-3p affects MINDY2
1 |
Hsa-miR-6759-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-6728-5p affects MINDY2
1 |
Hsa-miR-6728-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6513-5p affects MINDY2
1 |
Hsa-miR-6513-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6504-3p affects MINDY2
1 |
Hsa-miR-6504-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-619-5p affects MINDY2
1 |
Hsa-miR-619-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-6077 affects MINDY2
1 |
Hsa-miR-6077 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5580-5p affects MINDY2
1 |
Hsa-miR-5580-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5100 affects MINDY2
1 |
Hsa-miR-5100 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-510-3p affects MINDY2
1 |
Hsa-miR-510-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-5096 affects MINDY2
1 |
Hsa-miR-5096 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5095 affects MINDY2
1 |
Hsa-miR-5095 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5089-5p affects MINDY2
1 |
Hsa-miR-5089-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-494-3p affects MINDY2
1 |
Hsa-miR-494-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4802-3p affects MINDY2
1 |
Hsa-miR-4802-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4781-3p affects MINDY2
1 |
Hsa-miR-4781-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4755-3p affects MINDY2
1 |
Hsa-miR-4755-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4670-3p affects MINDY2
1 |
Hsa-miR-4670-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-4524b-3p affects MINDY2
1 |
Hsa-miR-4524b-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4524a-3p affects MINDY2
1 |
Hsa-miR-4524a-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-450b-3p affects MINDY2
1 |
Hsa-miR-450b-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-4435 affects MINDY2
1 |
Hsa-miR-4435 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-411-5p affects MINDY2
1 |
Hsa-miR-411-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-409-3p affects MINDY2
1 |
Hsa-miR-409-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-3942-3p affects MINDY2
1 |
Hsa-miR-3942-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-335-5p affects MINDY2
1 |
Hsa-miR-335-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18185580
Hsa-miR-3190-5p affects MINDY2
1 |
Hsa-miR-3190-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-197-3p affects MINDY2
1 |
Hsa-miR-197-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-192-5p affects MINDY2
1 |
Hsa-miR-192-5p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19074876
Hsa-miR-1273g-3p affects MINDY2
1 |
Hsa-miR-1273g-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-124-3p affects MINDY2
1 |
Hsa-miR-124-3p decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668037
Folic acid affects MINDY2
1 |
Folic acid decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
22206623
Flutamide affects MINDY2
1 |
Flutamide decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
24793618
Doxorubicin affects MINDY2
1 |
Doxorubicin decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
29803840
Diuron affects MINDY2
1 |
Diuron increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
25152437
Deltamethrin affects MINDY2
1 |
Deltamethrin increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
37019170
Crocidolite asbestos decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
29523930
Clofibrate affects MINDY2
1 |
Clofibrate decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
23811191
Cisplatin affects MINDY2
1 |
Cisplatin decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
27392435
Chlorpyrifos affects MINDY2
1 |
Chlorpyrifos decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
18668222
Chloroprene affects MINDY2
1 |
Chloroprene increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
23125180
Cck affects MINDY2
| 1
Cck activates MINDY2. 1 / 1
| 1
reach
"The cell viability and colony-forming ability of PC cells were significantly reduced after silencing MINDY2, and this ability was significantly enhanced after upregulating MINDY2 by CCK8 and clonogenic plate experiments ( Figures 4D, E )."
37207150
Aristolochic acid A decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
33212167
Alpha-phellandrene increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
25075043
Aflatoxin B1 affects MINDY2
1 |
Aflatoxin B1 increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
19770486
TUBB8 affects MINDY2
1 |
MINDY2 binds TUBB8. 1 / 1
1 |
biogrid
No evidence text available
33961781
TLX2 affects MINDY2
1 |
TLX2 decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
Soman affects MINDY2
1 |
Soman decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
19281266
Smoke affects MINDY2
1 |
Smoke decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
34520756
SREBF1 affects MINDY2
1 |
SREBF1 decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
SPTBN1 affects MINDY2
1 |
SPTBN1 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
35575683
SLC27A6 affects MINDY2
1 |
biogrid
No evidence text available
26186194
S-2-pentyl-4-pentynoic hydroxamic acid increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
21427059
RUNX2 affects MINDY2
1 |
RUNX2 decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
Plant Extracts affects MINDY2
1 |
Plant Extracts increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
23557933
Pancreatic Neoplasms activates MINDY2. 1 / 1
| 1
reach
"Therefore, we conducted a series of cell biology tests after silencing ACTN4 in PC cells overexpressing MINDY2 and discovered that silencing ACTN4 reversed the pro-carcinogenic role of MINDY2 in PC."
37207150
PRKD2 affects MINDY2
1 |
PRKD2 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
30652415
NF1 affects MINDY2
1 |
NF1 decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
NEK4 affects MINDY2
1 |
NEK4 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
25798074
NCR3LG1 affects MINDY2
1 |
biogrid
No evidence text available
26186194
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal activates MINDY2. 1 / 1
| 1
reach
"We also discovered that the addition of the proteasome inhibitor MG132 eliminated MINDY2’s ability to regulate ACTN4 protein expression ( Figure 6F )."
37207150
MIR375 affects MINDY2
1 |
MIR375 decreases the amount of MINDY2. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20215506
MINDY2 affects cell cycle
| 1
MINDY2 inhibits cell cycle. 1 / 1
| 1
reach
"Flow cytometry demonstrated that MINDY2 inhibited the G1/S phase transition of the cell cycle ( Figure 7D )."
37207150
MINDY2 affects TUBB8
1 |
MINDY2 binds TUBB8. 1 / 1
1 |
biogrid
No evidence text available
33961781
MINDY2 affects SPTBN1
1 |
SPTBN1 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
35575683
MINDY2 affects SLC27A6
1 |
biogrid
No evidence text available
26186194
MINDY2 affects PRKD2
1 |
PRKD2 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
30652415
reach
"Moreover, the Kaplan-Meier analysis of survival demonstrated that the overall survival of patients with high MINDY2 expression was considerably lower than that of the control group ( Figure 3D ).2.3 MINDY2 promotes PC cell proliferation, invasion, and migration in vitro ."
37207150
MINDY2 affects NEK4
1 |
NEK4 binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
25798074
MINDY2 affects NCR3LG1
1 |
biogrid
No evidence text available
26186194
MINDY2 affects MINDY2
| 1
MINDY2 leads to the methylation of MINDY2. 1 / 1
| 1
reach
"Overall, this suggests that the FAM63B methylation differences seen in whole blood from BD and controls are not strongly driven by SNPs in FAM63B, at least those that are on the Affymetrix 500K array."
27175219
MINDY2 affects KLC1
1 |
MINDY2 binds KLC1. 1 / 1
1 |
biogrid
No evidence text available
21915095
MINDY2 affects IKBIP
1 |
MINDY2 binds IKBIP. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY2 affects HSDL1
1 |
MINDY2 binds HSDL1. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY2 affects GPX1
1 |
MINDY2 binds GPX1. 1 / 1
1 |
biogrid
No evidence text available
33961781
MINDY2 affects GNA13
1 |
MINDY2 binds GNA13. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY2 affects Cell Survival
| 1
MINDY2 activates Cell Survival. 1 / 1
| 1
reach
"To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed ( Figures 7A–C )."
37207150
MINDY2 affects CTU1
1 |
MINDY2 binds CTU1. 1 / 1
1 |
biogrid
No evidence text available
26186194
MINDY2 affects CADPS
1 |
CADPS binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
33961781
MEF2A affects MINDY2
1 |
MEF2A decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
KLC1 affects MINDY2
1 |
MINDY2 binds KLC1. 1 / 1
1 |
biogrid
No evidence text available
21915095
IKBIP affects MINDY2
1 |
MINDY2 binds IKBIP. 1 / 1
1 |
biogrid
No evidence text available
26186194
HSDL1 affects MINDY2
1 |
MINDY2 binds HSDL1. 1 / 1
1 |
biogrid
No evidence text available
26186194
GSK-J4 affects MINDY2
1 |
GSK-J4 increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
29301935
GPX1 affects MINDY2
1 |
MINDY2 binds GPX1. 1 / 1
1 |
biogrid
No evidence text available
33961781
GNA13 affects MINDY2
1 |
MINDY2 binds GNA13. 1 / 1
1 |
biogrid
No evidence text available
26186194
FR900359 affects MINDY2
1 |
FR900359 dephosphorylates MINDY2. 1 / 1
1 |
ctd
No evidence text available
37730182
ELK1 affects MINDY2
1 |
ELK1 decreases the amount of MINDY2. 1 / 1
1 |
biopax:msigdb
No evidence text available
DDE affects MINDY2
1 |
DDE decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
38568856
Cyclin affects MINDY2
| 1
Cyclin increases the amount of MINDY2. 1 / 1
| 1
reach
"Western blot analysis revealed that the expression levels of Cyclin D1, Cyclin E1, CDK2, and CDK4 increased following MINDY2 overexpression, while these cyclins were decreased after the downregulation of MINDY2 compared with the control group ( Figure 4G )."
37207150
CTU1 affects MINDY2
1 |
MINDY2 binds CTU1. 1 / 1
1 |
biogrid
No evidence text available
26186194
CDK4 affects MINDY2
| 1
CDK4 increases the amount of MINDY2. 1 / 1
| 1
reach
"Western blot analysis revealed that the expression levels of Cyclin D1, Cyclin E1, CDK2, and CDK4 increased following MINDY2 overexpression, while these cyclins were decreased after the downregulation of MINDY2 compared with the control group ( Figure 4G )."
37207150
CDK2 affects MINDY2
| 1
CDK2 increases the amount of MINDY2. 1 / 1
| 1
reach
"Western blot analysis revealed that the expression levels of Cyclin D1, Cyclin E1, CDK2, and CDK4 increased following MINDY2 overexpression, while these cyclins were decreased after the downregulation of MINDY2 compared with the control group ( Figure 4G )."
37207150
CADPS affects MINDY2
1 |
CADPS binds MINDY2. 1 / 1
1 |
biogrid
No evidence text available
33961781
2-phenylethylamine leads to the methylation of MINDY2. 1 / 1
| 1
reach
"Additionally, PEA induced the hypermethylation of Celsr2 promoter and Fam63b in genebody, genes associated with blood lipids and T2DM [39,79], triglyceride, HDL and LDL phenotypes [80]."
40153413
17alpha-ethynylestradiol increases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
29097150
1,2-dimethylhydrazine decreases the amount of MINDY2. 1 / 1
1 |
ctd
No evidence text available
22206623