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MINDY2 activates cell population proliferation. 3 / 3
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"Moreover, the Kaplan-Meier analysis of survival demonstrated that the overall survival of patients with high MINDY2 expression was considerably lower than that of the control group ( Figure 3D ).2.3 MINDY2 promotes PC cell proliferation, invasion, and migration in vitro ."
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"To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed ( Figures 7A–C )."
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"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
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