IndraLab

Statements

eidos
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation , invasive metastasis , and EMT ."
37207150
reach
"In contrast, the knockdown MINDY2 group significantly inhibited PC cell liver metastasis in vivo ( Figure 5C )."
37207150
reach
"Thus, MINDY2 promoted PC growth and liver metastasis in vivo.2.5 MINDY2 interacts with ACTN4 and stabilizes ACTN4 by deubiquitination function."
37207150
reach
"To further clarify the role of ACTN4 in the cancer-promoting process of MINDY2, after we down-regulated ACTN4 and upregulated MINDY2 co-treated BxPC-3 cells, the results of CCK-8, clonal plate, and EdU experiments suggested that the function of MINDY2 in enhancing PC cell viability and proliferation ability was reversed ( Figures 7A–C )."
37207150
reach
"In vivo and in vitro experiments further suggested that elevated MINDY2 promotes PC proliferation, invasive metastasis, and EMT."
37207150
reach
"We found that the expression level of MINDY2 was elevated in PC."
37207150
eidos
"The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K / AKT / mTOR signaling pathway ."
37207150
reach
"Moreover, the Kaplan-Meier analysis of survival demonstrated that the overall survival of patients with high MINDY2 expression was considerably lower than that of the control group ( Figure 3D ).2.3 MINDY2 promotes PC cell proliferation, invasion, and migration in vitro ."
37207150
reach
"MINDY2 stabilized ACTN4 expression and then promoted the growth and metastasis of PC [36]."
39907925
reach
"In light of the preceding findings, MINDY2 may increase the invasion and metastasis of PC cells via EMT.2.4 MINDY2 promotes PC growth and liver metastasis in vivo ."
37207150