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ACTN4 activates MINDY2. 3 / 3
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"Therefore, we conducted a series of cell biology tests after silencing ACTN4 in PC cells overexpressing MINDY2 and discovered that silencing ACTN4 reversed the pro-carcinogenic role of MINDY2 in PC."
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"Also, it was found that the knockdown of ACTN4 reduced the ability of MINDY2 to promote EMT ( Figure 7E ); both the Transwell test and the wound healing experiment demonstrated that MINDY2’s capacity to encourage PC cell invasion and migration was significantly reduced ( Figures 7F, G )."
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"First, we found that the half-life of ACTN4 was significantly prolonged after treating cells overexpressing MINDY2 with CHX, and the half-life of ACTN4 was shortened after silencing MINDY2.Furthermore, the regulatory effect of MINDY2 on ACTN4 protein disappeared after the addition of MG132-treated cells."
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