IndraLab

Statements

TP53 affects USP1
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TP53 decreases the amount of USP1.
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TP53 decreases the amount of USP1. 10 / 10
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"P53 represses USP1 and BRD4 expression through the P21-RB1 axis."
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"To examine whether P53 repressed USP1 expression at the transcription level, we constructed luciferase reporter plasmid driven by USP1 promoter and stably expressed this construct in liver cancer cells."
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"6, G and H and S6C), which supported P53 repressed USP1 transcription."
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"Next, we investigated how P53 triggered repression of USP1 transcription."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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"Consistently, the CA9 mRNA levels also negatively correlated with P53 and RB1 protein levels in P53 WT samples (Fig. S6, L and M), which is consistent with the finding that P53 repressed USP1 transcription through RB1."
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"Collectively, these data revealed that P53 repressed USP1 transcription and BRD4 expression through the P21–RB1 axis (Fig. 7)."
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"In this study, we uncover that transcription of USP1 is repressed by a master tumor suppressor gene, TP53."
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"We found overexpressing P53 decreased USP1 protein level (Figs."
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"Mechanistically, P53 indirectly represses the transcription of USP1, a deubiquitinase, through the P21-RB1 axis."
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TP53 increases the amount of USP1.
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TP53 increases the amount of USP1. 5 / 5
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"6, G and H and S6C), which supported P53 repressed USP1 transcription."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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"Consistently, the CA9 mRNA levels also negatively correlated with P53 and RB1 protein levels in P53 WT samples (Fig. S6, L and M), which is consistent with the finding that P53 repressed USP1 transcription through RB1."
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"Collectively, these data revealed that P53 repressed USP1 transcription and BRD4 expression through the P21–RB1 axis (Fig. 7)."
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"Consistently, knocking-down P53 in P53 WT HepG2 and SK-HEP-1 cells increased USP1 protein level (Fig. 6B)."
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USP1 affects TP53
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USP1 inhibits TP53.
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USP1 inhibits TP53. 3 / 3
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"Similarly, USP1 inhibits TfR1 and p53, but USP7 is upregulated in I/R injury."
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"Similarly, USP1 inhibits TfR1 and p53, but USP7 is upregulated in I/R injury."
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"Knocking-down USP1 diminished the effect of P53 on BRD4 expression, indicating USP1 was required for BRD4 regulation by P53 (Fig. 3L)."
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USP1 activates TP53.
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USP1 activates TP53. 3 / 3
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"The tumor suppressor p53, a well-known inducer of CDKN1A, was not increased by USP1 knockdown, suggesting that increased p21 was p53 independent.p21 is a potent inhibitor of cell cycle progression (Po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, hypoxia-inducible circWSB1 was significantly upregulated and interacts with USP10 to reduce the stability of p53 caused by USP1 and promote the progression of BC tissues [46]."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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USP1 decreases the amount of TP53.
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USP1 decreases the amount of TP53. 1 / 1
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"USP1 inhibition did not induce p53 expression or γ-H2AX nuclear foci formation (data not shown), indicating that FANCD2-L upregulation was not an indirect effect of DNA damage.Next we tested whether t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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