IndraLab

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TP53 decreases the amount of USP1. 10 / 10
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"P53 represses USP1 and BRD4 expression through the P21-RB1 axis."
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"To examine whether P53 repressed USP1 expression at the transcription level, we constructed luciferase reporter plasmid driven by USP1 promoter and stably expressed this construct in liver cancer cells."
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"6, G and H and S6C), which supported P53 repressed USP1 transcription."
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"Next, we investigated how P53 triggered repression of USP1 transcription."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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"Consistently, the CA9 mRNA levels also negatively correlated with P53 and RB1 protein levels in P53 WT samples (Fig. S6, L and M), which is consistent with the finding that P53 repressed USP1 transcription through RB1."
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"Collectively, these data revealed that P53 repressed USP1 transcription and BRD4 expression through the P21–RB1 axis (Fig. 7)."
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"In this study, we uncover that transcription of USP1 is repressed by a master tumor suppressor gene, TP53."
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"We found overexpressing P53 decreased USP1 protein level (Figs."
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"Mechanistically, P53 indirectly represses the transcription of USP1, a deubiquitinase, through the P21-RB1 axis."
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