IndraLab

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USP1 activates TP53. 3 / 3
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"The tumor suppressor p53, a well-known inducer of CDKN1A, was not increased by USP1 knockdown, suggesting that increased p21 was p53 independent.p21 is a potent inhibitor of cell cycle progression (Po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, hypoxia-inducible circWSB1 was significantly upregulated and interacts with USP10 to reduce the stability of p53 caused by USP1 and promote the progression of BC tissues [46]."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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