IndraLab

Statements

TP53 increases the amount of USP1. 5 / 5
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"6, G and H and S6C), which supported P53 repressed USP1 transcription."
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"The result showed either knockdown diminished the repressive effect of P53 on USP1-promoter reporter (Fig. 6R), which supports that P53 represses USP1 transcription through the P21–RB1 axis."
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"Consistently, the CA9 mRNA levels also negatively correlated with P53 and RB1 protein levels in P53 WT samples (Fig. S6, L and M), which is consistent with the finding that P53 repressed USP1 transcription through RB1."
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"Collectively, these data revealed that P53 repressed USP1 transcription and BRD4 expression through the P21–RB1 axis (Fig. 7)."
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"Consistently, knocking-down P53 in P53 WT HepG2 and SK-HEP-1 cells increased USP1 protein level (Fig. 6B)."
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