IndraLab

Statements

TNFAIP3 affects NFKBIA
| 1 2 6 1
TNFAIP3 binds NFKBIA.
| 5
sparser
"The expression of p300ΔC-1087 is thus associated with a reduction in A20 and IκBα expression at both the mRNA and protein levels."
24529102
sparser
"Such a balance is controlled by a combination of molecular scale biochemical processes identified in detail in this study, such as IKKK activity, A20 and IκBα interactions, and stability of mRNA transcripts associated with NF-κB-mediated responses."
22685435
sparser
"It was released from IkappaB and translocated to the nucleus but failed to bind to the kappaB site of the target A20 gene promoter."
17178723
TNFAIP3 binds NFKBIA and PTGS2. 1 / 1
| 1
sparser
"In agreement with the prolonged nuclear retention of RelA(TA2) mutant due to a defective negative feedback loop, reduced amounts of the RelA(TA2) mutant remained bound to the tnfaip3 , nfkbia , and ptgs2 promoters even at 60 min after stimulation."
24019758
HLA-C binds RIGI, IL4, NFKBIA, and TNFAIP3. 1 / 1
| 1
sparser
"These included genes such as chemokines CXCL1 , CXCL10 and CXCL8 and genes associated with autoimmune diseases such as HLA-C , DDX58 , IL4 , NFKBIA and TNFAIP3 which are associated with psoriasis susceptibility.[ xref ] Moreover, NFKB1 from this module mediates Th1/Th17 activation in the pathogenesis of psoriasis and probably other autoimmune diseases.[ xref ] Green genes also had more DMRs, either in the gene bodies or in GH elements mapped to the genes, suggesting that TNFa stimulation causes more long-lasting changes to gene expression to genes in the green set than to other sets."
32231389
TNFAIP3 inhibits NFKBIA.
| 2
TNFAIP3 inhibits NFKBIA. 2 / 2
| 2
reach
"Furthermore, we observed a downregulation of several TNF-induced genes that play a central role in curtailing TNF signalling, including the inhibitors of NFkB, NFKBIZ and NFKBIA, RGS1, TNFAIP3 and AREG.Consistent with this observation, Oncostatin M (OSM), a pro-inflammatory cytokine shown to be increased in inflammatory bowel disease patients with poor response to anti-TNF therapy 27 , was also downregulated by iLD-IL-2."
| DOI
reach
"In the current research (Figure 7), we proved that folic acid supplementation causes the down-regulation of NFKBIA and TNF alpha-induced protein 3 (TNFAIP3) which are involved in the negative mediation of NF-kappaB transcription factor activity."
31010964
TNFAIP3 phosphorylates NFKBIA.
| 1
TNFAIP3 phosphorylates NFKBIA. 1 / 1
| 1
sparser
"The exact molecular events are not well understood; however, B cells lacking A20 display increased phosphorylation of IκBα as well as p100 in response to anti-CD40 (Tavares et al. xref , Chu et al. xref )."
28524749
TNFAIP3 increases the amount of NFKBIA.
| 1
TNFAIP3 increases the amount of NFKBIA. 1 / 1
| 1
isi
"The water extract of LFH can significantly reduce the content of inflammatory factors in rats with ALI, and down-regulate the mRNA expression of TNFAIP3, IL1 R1, IL6 R and NFKBIA in the lung tissues, showing significant anti-inflammatory effect."
33350272
TNFAIP3 activates NFKBIA.
| 1
TNFAIP3 activates NFKBIA. 1 / 1
| 1
eidos
"The simulations furthermore show that the absence of A20 leads to a decrease in IkappaBalpha concentration in all three models ."
32848849
NFKBIA affects TNFAIP3
| 2 7
NFKBIA binds TNFAIP3.
| 5
sparser
"The expression of p300ΔC-1087 is thus associated with a reduction in A20 and IκBα expression at both the mRNA and protein levels."
24529102
sparser
"Such a balance is controlled by a combination of molecular scale biochemical processes identified in detail in this study, such as IKKK activity, A20 and IκBα interactions, and stability of mRNA transcripts associated with NF-κB-mediated responses."
22685435
sparser
"It was released from IkappaB and translocated to the nucleus but failed to bind to the kappaB site of the target A20 gene promoter."
17178723
TNFAIP3 binds NFKBIA and PTGS2. 1 / 1
| 1
sparser
"In agreement with the prolonged nuclear retention of RelA(TA2) mutant due to a defective negative feedback loop, reduced amounts of the RelA(TA2) mutant remained bound to the tnfaip3 , nfkbia , and ptgs2 promoters even at 60 min after stimulation."
24019758
HLA-C binds RIGI, IL4, NFKBIA, and TNFAIP3. 1 / 1
| 1
sparser
"These included genes such as chemokines CXCL1 , CXCL10 and CXCL8 and genes associated with autoimmune diseases such as HLA-C , DDX58 , IL4 , NFKBIA and TNFAIP3 which are associated with psoriasis susceptibility.[ xref ] Moreover, NFKB1 from this module mediates Th1/Th17 activation in the pathogenesis of psoriasis and probably other autoimmune diseases.[ xref ] Green genes also had more DMRs, either in the gene bodies or in GH elements mapped to the genes, suggesting that TNFa stimulation causes more long-lasting changes to gene expression to genes in the green set than to other sets."
32231389
NFKBIA activates TNFAIP3.
| 1 1
NFKBIA activates TNFAIP3. 2 / 2
| 1 1
reach
"In the current research (Figure 7), we proved that folic acid supplementation causes the down-regulation of NFKBIA and TNF alpha-induced protein 3 (TNFAIP3) which are involved in the negative mediation of NF-kappaB transcription factor activity."
31010964
sparser
"Endogenous MALT1 activity was evaluated by western blotting for A20, BCL10, and CYLD, and NF-κB activation by phospho-IκB-α and total IκB-α ( xref )."
23238016
NFKBIA phosphorylates TNFAIP3.
| 1
NFKBIA phosphorylates TNFAIP3. 1 / 1
| 1
sparser
"Consistently, the pivotal role of modulation of sphingolipids in δTE-mediated A20 upregulation and anti-NF-κB is also supported by the observation that pharmacological blockage of de novo sphingolipids synthesis with myriocin, which prevents accumulation of dhCers, diminished δTE’s inhibitory effect on IκBα phosphorylation and induction of A20."
30471562
NFKBIA inhibits TNFAIP3.
| 1
NFKBIA inhibits TNFAIP3. 1 / 1
| 1
reach
"This was attributable at least partially to the NIK induced overexpression of some canonical pathway inhibitors like Nfkbia, Nfkbie, and Tnfaip3 (A20) (XREF_FIG)."
27733012
NFKBIA affects NFkappaB, REL, TNF, TNFAIP3, TNIP1, and TRAF3IP2
| 1
TNIP1 binds TNFAIP3, TRAF3IP2, NFKBIA, REL, TNF, and NFkappaB. 1 / 1
| 1
sparser
"TNIP1 , TNFAIP3 , TRAF3IP2 , NFKBIA , and REL are associated with the TNF-α pathway and activation of NF-κB; while IL23R , IL12B , IL23A , and TYK2 are associated with activation of the Th17 pathway."
22577363
NFKBIA affects IL4
| 1
HLA-C binds RIGI, IL4, NFKBIA, and TNFAIP3. 1 / 1
| 1
sparser
"These included genes such as chemokines CXCL1 , CXCL10 and CXCL8 and genes associated with autoimmune diseases such as HLA-C , DDX58 , IL4 , NFKBIA and TNFAIP3 which are associated with psoriasis susceptibility.[ xref ] Moreover, NFKB1 from this module mediates Th1/Th17 activation in the pathogenesis of psoriasis and probably other autoimmune diseases.[ xref ] Green genes also had more DMRs, either in the gene bodies or in GH elements mapped to the genes, suggesting that TNFa stimulation causes more long-lasting changes to gene expression to genes in the green set than to other sets."
32231389