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TNFAIP3 inhibits NFKBIA. 2 / 2
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"Furthermore, we observed a downregulation of several TNF-induced genes that play a central role in curtailing TNF signalling, including the inhibitors of NFkB, NFKBIZ and NFKBIA, RGS1, TNFAIP3 and AREG.Consistent with this observation, Oncostatin M (OSM), a pro-inflammatory cytokine shown to be increased in inflammatory bowel disease patients with poor response to anti-TNF therapy 27 , was also downregulated by iLD-IL-2."
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"In the current research (Figure 7), we proved that folic acid supplementation causes the down-regulation of NFKBIA and TNF alpha-induced protein 3 (TNFAIP3) which are involved in the negative mediation of NF-kappaB transcription factor activity."
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