IndraLab

Statements

UBR5 affects OTUD5
| 7 5
UBR5 binds OTUD5.
| 5 5
UBR5 binds OTUD5. 8 / 8
| 5 3
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
sparser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
reach
"OTUD5 localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis."
30508113
sparser
"First, OTUD5 interacts with UBR5 and represses RNA Pol II-mediated elongation and RNA synthesis."
32268558
reach
"The OTUD5 and UBR5 complex regulates FACT mediated transcription at damaged chromatin."
30508113
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
sparser
"Mass spectrometry coupled to short interfering RNA (siRNA) screening of ubiquitinated proteins in Duba −/− Th17 cells revealed that DUBA directly bound and deubiquitinated UBR5 (Ubiquitin protein ligase E3 component n-recognin 5)."
34635393
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
UBR5 inhibits OTUD5.
| 1
UBR5 bound to OTUD5 inhibits OTUD5. 1 / 1
| 1
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
UBR5 activates OTUD5.
| 1
UBR5 activates OTUD5. 1 / 1
| 1
reach
"UBR5 destabilizes DUBA through ubiquitylation, whereas DUBA stabilizes UBR5 in activated T cells by attenuating degradative auto-ubiquitylation, triggering UBR5 mediated ubiquitylation of the transcription factor RORyt in response to TGF-beta [XREF_BIBR]."
27834739
OTUD5 affects UBR5
1 | 6 5
OTUD5 binds UBR5.
| 5 5
UBR5 binds OTUD5. 8 / 8
| 5 3
reach
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
sparser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells."
25470037
reach
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
reach
"OTUD5 localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis."
30508113
sparser
"First, OTUD5 interacts with UBR5 and represses RNA Pol II-mediated elongation and RNA synthesis."
32268558
reach
"The OTUD5 and UBR5 complex regulates FACT mediated transcription at damaged chromatin."
30508113
reach
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells (XREF_FIG)."
| PMC
sparser
"Mass spectrometry coupled to short interfering RNA (siRNA) screening of ubiquitinated proteins in Duba −/− Th17 cells revealed that DUBA directly bound and deubiquitinated UBR5 (Ubiquitin protein ligase E3 component n-recognin 5)."
34635393
SUPT16H binds UBR5 and OTUD5. 1 / 1
| 1
sparser
"OTUD5 interacts with UBR5 and SPT16 independently through two distinct regions, and both interactions are necessary for arresting the Pol II elongation at lesions."
30508113
UBR5 binds OTUD5, HCFC1, and HDAC2. 1 / 1
| 1
sparser
"We could confirm the interactions between OTUD5 and ARID1A/B, HDAC2, HCF1, and UBR5 by immunoblotting at the endogenous level in hES H1 cells ( xref )."
| PMC
OTUD5 deubiquitinates UBR5.
1 | 1
OTUD5 deubiquitinates UBR5. 2 / 2
1 | 1
reach
"When DUBA deubiquitylates UBR5 and rescues it from degradation, UBR5 is free to polyubiquitylate RORgammaT, driving its degradation and consequently limiting Th17 differentiation."
27183634
ubibrowser
"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells. DUBA accumulated in activated T cells and stabilized UBR5, which then ubiquitylated ROR纬t in response to TGF-尾 signalling.?"
25470037