IndraLab

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ANG translocates to the nucleus. 10 / 274
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"During the study of the mechanism by which ANG is translocated to the nucleus of endothelial cells, neomycin, a phospholipase C (PLC) inhibitor, was found to block nuclear translocation of ANG [XREF_BIBR]."

sparser
"This normally well-controlled process of nuclear translocation of ANG is hijacked by cancer cells that constitutively uptake ANG and translocate it into the nucleus so that rRNA is constantly transcribed to meet a higher metabolic requirement of this cells."

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"Angiogenin (ANG) can translocate to the target cell nucleus and accumulate in the nucleolus to enhance rRNA transcription, thus promoting cell proliferation."

sparser
"Ectopic expression of human PLXNB2 in COS-7 cells, which express a low level of endogenous monkey PlxnB2 ( xref ), enabled nuclear translocation of ANG ( xref ) and AKT phosphorylation ( xref ) upon ANG stimulation in these originally ANG-unresponsive cells."

sparser
"We have now established that neamine ( xref ), a nontoxic degradation product of neomycin, effectively inhibits nuclear translocation of ANG ( xref )."

sparser
"Angiogenin is constitutively translocated to the nucleus in HUVEC cells."

sparser
"In efforts to understand the mechanism by which ANG is translocated to the nucleus of endothelial cells, neomycin was discovered to block nuclear translocation of ANG and to inhibit ANG-induced cell proliferation and angiogenesis [ xref ]."

sparser
"Inhibition of nuclear translocation of ANG resulted in reduced BCBL-1 and TIVE-LTC (latently infected endothelial) cell survival and proliferation, while EBV(-) and EBV(+) Akata cells were unaffected."

sparser
"Nuclear translocation of angiogenin does not occur in nonproliferative, confluent CPAE cells."

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"When cells have a high metabolic demand and need more ribosomes, ANG is taken up by the cells through receptor mediated endocytosis and is translocated to the nucleus."
ANG translocates to the cytoplasm. 6 / 6
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sparser
"Given the facts that phosphorylation of VE-cadherin was enhanced and endocytosis of disassembled VE-cadherin increased when cytoplasmic translocation of exogenous ANG took place, we conclude that, in addition to its angiogenic role, ANG is a key enhancing factor on endothelial barrier dysfunction."

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"As a stress activated and secreted ribonuclease, ANG can be transported to the cytoplasm under stress conditions."

sparser
"By investigating the function and potential effects of this compartmentalized translocation of ANG, we found that rickettisial infection-triggered cytoplasmic translocation of ANG, enhanced phosphorylation of VE-cadherin, reduced VE-cadherin stability, and attenuated endothelial barrier function."

sparser
"Most importantly, ANG was translocated into the cytoplasm at 48 hrs p.i. (Figure  xref K) and predominated in the cytoplasmic location at 72 hrs p.i. (Figure  xref L)."

sparser
"However, there is no direct evidence of cytoplasmic translocation of ANG in endothelial cells triggered by adverse events [ xref ]."

sparser
"The mechanism by which SFG rickettsial infection-triggered cytoplasmic translocation of ANG results in phosphorylation of VE-cadherin mediated endothelial barrier dysfunction has yet to be determined."
ANG translocates to the cytosol. 4 / 4
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"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."

sparser
"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."

reach
"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."

sparser
"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."
ANG translocates from the nucleus. 4 / 4
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"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."

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"The release of nuclear angiogenin from the nucleus by DNase I indicates that it can directly bind to nuclear DNA."

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"Several stressors induce ANG translocation from the nucleus into the cytoplasm, where it cleaves transfer RNAs (tRNAs) in the anticodon loop to produce tRNA derived stress induced RNA (tiRNAs) [XREF_BIBR, XREF_BIBR]."

sparser
"At the same time, under stress conditions, ANG translocates from the nucleus and accumulates in the cytoplasm, slicing mature tRNAs to produce tiRNAs [ xref ]."
ANG translocates to the nucleolus. 2 / 2
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"ANG binds to endothelial cells and translocates to nucleolus where it binds to DNA."

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"To promote cell growth and proliferation, angiogenin translocates to the nucleus and nucleolus where it stimulates rRNA transcription."
ANG translocates from the nucleus to the cytoplasm. 2 / 2
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sparser
"In response to different stress stimuli such as sodium arsenite (SA) treatment, ANG translocates into the cytoplasm from the nucleus, and dissociates from RNH1 ( xref )."

sparser
"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."
Modified ANG translocates to the cytoplasm. 1 / 1
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"Typically, exogenous ANG translocates into the nucleus at 24 hrs and to the cytoplasm at 72 hrs post-infection."
Modified ANG translocates to the nucleus. 1 / 1
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"ANG translocates to the nucleus, where it binds ribosomal DNA and stimulates the transcription of rRNA XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR for diverse functions beyond angiogenesis."