IndraLab

Statements


RAET1E affects KLRK1
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RAET1E binds KLRK1.
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"ULBP4-NKG2D interaction can not only activate NK cell and NK-mediated cytotoxicity [ xref , xref , xref ], but also serve to stimulate the cytotoxicity of CD8+ T cell [ xref ], which suggests an influence of ULBP4 on both innate and adaptive immune responses."

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"It is intriguing that ULBP-4 and hMSH2 can also bind to NKG2D to induce the cytotoxicity of Vgamma9Vdelta2-T cells against tumor cells through TCR and NKG2D engagement."
RAET1E inhibits KLRK1.
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RAET1E inhibits KLRK1. 3 / 3
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"RAET1E2, a soluble isoform of the UL16 binding protein RAET1E produced by tumor cells, inhibits NKG2D mediated NK cytotoxicity."

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"In other words, RAET1E might impair NKG2D mediated NK cell cytotoxicity to tumors [XREF_BIBR]."
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"We previously reported that RAET1E2, a soluble isoform of the RAET1E (ULBP4), inhibits NKG2D mediated NK cytotoxicity."
RAET1E decreases the amount of KLRK1.
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RAET1E decreases the amount of KLRK1. 1 / 2
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"Moreover, co-culture-free soluble forms of ULBP4 splice variants (their alpha1 + alpha2 ectodomains) and RAET1G3 (soluble splice variant of RAET1G2) with NK cells down-regulated the cell surface expression of NKG2D."
RAET1E activates KLRK1.
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RAET1E activates KLRK1. 1 / 2
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"Indeed a soluble, secreted splicing variant of RAET1E has also been reported XREF_BIBR Therefore expression of soluble isoforms of RAET1G and RAET1E could allow cancer cells to produce soluble NKG2D ligand without the need for metalloproteinase activity."
TGFB affects RAET1E
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TGFB decreases the amount of RAET1E. 4 / 4
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"TGF-beta inhibits the transcription of MICA, ULBP2, and ULBP4 mRNA, whereas MICB, ULBP1, and ULBP3 mRNA levels remained unchanged."

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"Secretion of TGF-beta by NPC cells is well documented and is known to promote the progression and metastasis of NPC [XREF_BIBR, XREF_BIBR], herein ULBP4 expression may be also downregulated by TGF-beta on NPC cells."

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"Additionally, transforming growth factor-beta (TGF-beta) selectively downregulates the expression of MICA, ULBP2, and ULBP4, but not MICB, ULBP1, or ULBP3, in malignant glioma cells [XREF_BIBR]."

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"We further delineate two independent mechanisms that can explain these expression patterns : (i) transforming growth factor-beta (TGF-beta) is upregulated during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected."
TCR affects RAET1E
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"ULBP4 also can bind to Vγ9Vδ2 TCR and thus induce the cytotoxic activity of Vγ9Vδ2T cells toward tumor cells through both TCR and NKG2D engagement ( xref )."

sparser
"They can be activated by γδ TCR ligands such as phosphoantigens, or by MHC-associated ligands of the activatory receptor killer cell lectin-like receptor subfamily K, member 1 (KLRK1, best known as NKG2D, such as MHC class I polypeptide-related sequence A (MICA), MICB, and various members of the UL16-binding protein (ULBP) family. γδ T cells also express killer-cell immunoglobulin-like receptors (KIRs), which can be either activatory or inhibitory, including killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 1 (KIR2DL1) xref and killer cell immunoglobulin-like receptor, 3 domains, long cytoplasmic tail, 1 (KIR3DL1). xref Tumors possess the ability to manipulate this balance to stimulate tolerance by inhibitory signals, including soluble NKG2D ligands, transforming growth factor β1 (TGFβ1), galectin 3 and prostaglandin E 2 (PGE 2 ) xref , xref , xref , xref Elevated circulating levels of sMICA, sMICB, and sULBP1 might be particularly active against effector γδ T cells, as the latter express high amounts of NKG2D. Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some γδ T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells. xref "

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"Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some gammadelta T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells."

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"We also show that ULBP4 binds to a soluble chimeric protein containing TCRgamma9 and delta2 and activates TCR (-) Jurkat T cells transfected with TCRgamma9 and delta2."
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Pirinixic acid increases the amount of RAET1E. 3 / 3
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RAET1E binds.
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RAET1E translocates.
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RAET1E translocates from the cytoplasm to the plasma membrane. 1 / 1
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sparser
"In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane."
E2F1 affects RAET1E
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E2F1 activates RAET1E.
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E2F1 activates RAET1E. 2 / 2
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"To investigate whether E2F1 activates the Raet1e promoter reporter construct described in XREF_FIG, fibroblasts maintained in 0% serum were cotransfected with the reporter construct and increasing amounts of a pcDNA vector encoding E2F1."

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"E2F1 was much less effective in activating a Raet1e reporter plasmid in which both putative E2F sites were mutated, indicating that E2F transcription factors directly bind and activate the Raet1e promoter construct (XREF_FIG, right)."
E2F1 binds RAET1E.
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sparser
"An investigation of the roles of factors known to regulate the cell cycle showed that E2F1–3, the activating E2F transcription factors, bind to the Raet1e promoter in vivo and transactivate the endogenous Raet1e gene as well as the Raet1e promoter in a reporter plasmid."
Reliable detection reagents affects RAET1E
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Reliable detection reagents activates RAET1E. 2 / 2
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eidos
"The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts [ 32 ] ."

eidos
"Reply : For clarification , we amended the text as follows : '' The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts ( Zoller et al ., 2018 ) ."
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Paracetamol decreases the amount of RAET1E. 2 / 2
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Carbon nanotube increases the amount of RAET1E.
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Carbon nanotube increases the amount of RAET1E. 1 / 1
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Carbon nanotube decreases the amount of RAET1E.
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Carbon nanotube decreases the amount of RAET1E. 1 / 1
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"Consistent with these findings, we observed that the chemical HDAC inhibitor butyrate activated the WT Raet1e promoter (XREF_FIG)."
Butyric acid activates mutated RAET1E. 1 / 1
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"Interestingly, butyrate treatment failed to drive expression from the m18RE * mutant Raet1e promoter (XREF_FIG)."
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Aflatoxin B1 methylates RAET1E.
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Aflatoxin B1 increases the amount of RAET1E.
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Aflatoxin B1 increases the amount of RAET1E. 1 / 1
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ULBP3 affects RAET1E
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sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
ULBP2 affects RAET1E
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sparser
"However, it is noteworthy that high expression of ULBP2 and ULBP4 has been paradoxically associated with poor prognosis in ovarian cancer, and it does not appear to be related to an increase of the shedding of these molecules ( xref , xref )."
RAET1G affects RAET1E
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"Given the results of Cao et al.’s study and the fact that many isoforms were also stained during RAET1E and RAET1G IHC staining, it is possible that high RAET1E and RAET1G expression may be associated with poor prognosis."

sparser
"Intriguingly, although the results of our multivariate analysis were not significant, in univariate analysis, high RAET1E or RAET1G expression was associated with poor disease-free survival (Table  xref )."
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"Our results indicate that Letal promotes tumor immune surveillance by promoting the survival and intratumoral expansion of antitumor cytotoxic lymphocytes."

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"These results suggest that Letal delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes."

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"Here we show that immobilized soluble ULBP4 (rULBP4) induces the proliferation of human ovarian epithelial carcinoma- or colonic carcinoma derived Vdelta2 (+) T cells in vitro."

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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
RAET1E affects ULBP3
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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
RAET1E affects ULBP2
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sparser
"However, it is noteworthy that high expression of ULBP2 and ULBP4 has been paradoxically associated with poor prognosis in ovarian cancer, and it does not appear to be related to an increase of the shedding of these molecules ( xref , xref )."
RAET1E affects RAET1G
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"Given the results of Cao et al.’s study and the fact that many isoforms were also stained during RAET1E and RAET1G IHC staining, it is possible that high RAET1E and RAET1G expression may be associated with poor prognosis."

sparser
"Intriguingly, although the results of our multivariate analysis were not significant, in univariate analysis, high RAET1E or RAET1G expression was associated with poor disease-free survival (Table  xref )."
RAET1E affects CD8
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RAET1E activates CD8. 2 / 2
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"As shown earlier, the intermediate cells had the highest expression of genes involved in co-stimulation and antigen presentation, but also genes involved in NK cell and CD8 T cell activation, such as MICB, RAET1E, RAET1G, RAET1L and ULBP3 were enriched on intermediate monocytes."

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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
1,2-dichloroethane decreases the amount of RAET1E. 2 / 2
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(+)-JQ1 compound decreases the amount of RAET1E. 2 / 2
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Trichloroethene increases the amount of RAET1E. 1 / 1
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Transcription factor JUNB decreases the amount of RAET1E. 1 / 1
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"The transcription of Raet1e was inhibited by the transcription factor JUNB in cell lines and mouse tissues XREF_BIBR."
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Titanium dioxide increases the amount of RAET1E. 1 / 1
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Sodium dodecyl sulfate decreases the amount of RAET1E. 1 / 1
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Silicon dioxide decreases the amount of RAET1E. 1 / 1
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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
Self-made mAb DUMO1 affects RAET1E
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Self-made mAb DUMO1 activates RAET1E. 1 / 1
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eidos
"In contrast , our self-made mAb DUMO1 specifically binds to ULBP4-transfected cell lines ( but not mock-transfected cells ) and recombinantly produced ULBP4 , but does not bind to cells that do NOT contain ULBP4 / RAET1E transcripts such as HepG2 cells or human monocytes ( see Zoller et al ., 2018 and our present manuscript ) ."
Rotenone affects RAET1E
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Rotenone decreases the amount of RAET1E. 1 / 1
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Resveratrol increases the amount of RAET1E. 1 / 1
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No evidence text available
Psmb9-a affects RAET1E
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"EBV LMP2A reduces MICA and ULBP4 in lymphoblastoid cell lines and inhibits recognition by CD8+ T cells [XREF_BIBR], and this allows it to block its recognition and destruction by NK cells."
Propanal affects RAET1E
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Propanal increases the amount of RAET1E. 1 / 1
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"To determine whether the ULBP4 protein is transmembrane or GPI linked, cells expressing the transiently transfected ULBP4 or MICB or ULBP3 were treated with phosphatidylinositol specific phospholipase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
Jinfukang affects RAET1E
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Jinfukang increases the amount of RAET1E. 1 / 1
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Hsa-miR-8485 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-7977 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-6847-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-6821-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-6811-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-6733-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-6514-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-5690 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-557 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-512-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-510-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-507 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-450b-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-4302 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-4284 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-4276 decreases the amount of RAET1E. 1 / 1
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Hsa-miR-3680-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-33b-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-33a-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-24-3p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-214-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-129-5p decreases the amount of RAET1E. 1 / 1
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Hsa-miR-1268b decreases the amount of RAET1E. 1 / 1
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Hsa-miR-1268a decreases the amount of RAET1E. 1 / 1
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Hsa-miR-124-3p decreases the amount of RAET1E. 1 / 1
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sparser
"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."
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Formaldehyde increases the amount of RAET1E. 1 / 1
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No evidence text available
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Fenofibrate increases the amount of RAET1E. 1 / 1
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Endosulfan affects RAET1E
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Endosulfan increases the amount of RAET1E. 1 / 1
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Dichloroacetic acid increases the amount of RAET1E. 1 / 1
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Dibenz[a,h]anthracene decreases the amount of RAET1E. 1 / 1
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Clofibrate affects RAET1E
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Clofibrate increases the amount of RAET1E. 1 / 1
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Avobenzone affects RAET1E
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Avobenzone decreases the amount of RAET1E. 1 / 1
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Aluminium atom decreases the amount of RAET1E. 1 / 1
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Vgamma9Vdelta2 affects RAET1E
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Vgamma9Vdelta2 activates RAET1E. 1 / 1
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"Overexpression of the NKG2D ligands ULBP1 and ULBP4 by hematological and epithelial tumors, respectively, drives efficient cytotoxic responses by Vgamma9Vdelta2 T-cells."
ULBP3 affects MICA
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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
TNFSF9 affects RAET1E
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TFF2 affects RAET1E
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TFF2 inhibits RAET1E. 1 / 1
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"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."
TCRgamma9 affects RAET1E
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RAET1E binds TCRgamma9. 1 / 1
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"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."
SDK2 affects RAET1E
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RYK affects RAET1E
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"It remains unclear, however, whether AP-1 acts directly on the Raet1e gene to repress transcription or by an indirect mechanism that alters Raet1e transcription or mRNA stability."
RAET1E affects soluble 35-kDa protein
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RAET1E activates soluble 35-kDa protein. 1 / 1
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eidos
"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble , 35-kDa protein ( named RAET1E2 ) in tumor cells ."
| PMC
RAET1E affects pspA
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RAET1E activates pspA. 1 / 1
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"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble, 35-kDa protein (named RAET1E2) in tumor cells."
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RAET1E affects luciferase reporter construct
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RAET1E activates luciferase reporter construct. 1 / 1
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"E2F overexpression was sufficient to activate endogenous Raet1 genes in cells as well as a luciferase reporter construct driven by the Raet1e promoter."
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"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."
RAET1E affects atherosclerosis modifier locus Ath11 10b
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RAET1E activates atherosclerosis modifier locus Ath11 10b. 1 / 1
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"Altered expression of Raet1e, a major histocompatibility complex class 1 like molecule, underlies the atherosclerosis modifier locus Ath11 10b."
RAET1E affects adverse response
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RAET1E activates adverse response. 1 / 1
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eidos
"We then transiently knocked down the expression of Raet1e via siRNA inUbr5 - / -4 T1 tumor ( Figure 5b ) , which , when implanted in mice , caused a partial reversal of the inhibited growth of the parental tumor ( Figure 5c ) , but did not alter thein vitro growth rates ( Figure S1E ) , suggesting that higher Raet1e expression may mediate an adverse response against the tumor and that UBR5 deficiency in tumor cells may generate immunogens that attract anti-tumor responses.Upregulated proteins inUbr5 - / -4 T1 tumor.Potential immunogens and interacting partners controlled by UBR5 ."
RAET1E affects TNFSF9
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RAET1E affects TCRgamma9
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RAET1E binds TCRgamma9. 1 / 1
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"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."
RAET1E affects T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e
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RAET1E activates T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e. 1 / 1
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eidos
"It has been shown to function as a ligand for both TCRgamma9delta2and NKG2D through which Raet1e induces T cell-mediated cytotoxicity to tumor cells.18Decreased Raet1e expression is a poor prognostic marker in nasopharyngeal carcinoma ,19 whereas high expression of Raet1e is an indicator of good prognosis in cervical cancer.20We first confirmed the MS finding of Raet1e 's overexpression by Western blot in WT and inUbr5 - / - cells treated with the proteasome inhibitor MG132 ( Figure 5a ) , which also indicated that Raet1e protein level was indeed regulated by a proteasome-mediated mechanism ."
RAET1E affects SDK2
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RAET1E affects RYK
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RAET1E affects RAE1
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RAET1E increases the amount of RAE1. 1 / 1
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"Although E2F sites in the Raet1e promoter have been shown to drive RAE-1 expression during proliferation, these sites were dispensable for activation of the Raet1e promoter by m18 (XREF_FIG)."
RAET1E affects RAB3B
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RAET1E affects PODXL2
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RAET1E affects Neoplasms
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eidos
"Ligands for NKG2D include MICA , ULBP4 , and ULBP1 , which are implicated in NKG2D mediated recognition of multiple cancers 8, 9 ."
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RAET1E affects NRN1
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RAET1E affects NKG2D-mediated NK cell cytotoxicity
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RAET1E inhibits NKG2D-mediated NK cell cytotoxicity. 1 / 1
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eidos
"In other words , RAET1E might impair NKG2D-mediated NK cell cytotoxicity to tumors [ 43 ] ."
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RAET1E affects NCR3LG1
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RAET1E affects Major Histocompatibility Complex Class 1
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RAET1E activates Major Histocompatibility Complex Class 1. 1 / 1
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"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."
RAET1E affects MICA
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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
RAET1E affects MFAP3
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RAET1E affects IGDCC4
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RAET1E affects IFNGR1
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RAET1E affects GOLIM4
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RAET1E affects FGFR2
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RAET1E affects FGFR1
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RAET1E affects FAS
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RAET1E decreases the amount of FAS. 1 / 1
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"Letal also down-regulated the expression of Fas in CD8+ cells and rendered them resistant to Fas ligand induced apoptosis."
RAET1E affects EPHA7
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RAET1E affects E2F1
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"An investigation of the roles of factors known to regulate the cell cycle showed that E2F1–3, the activating E2F transcription factors, bind to the Raet1e promoter in vivo and transactivate the endogenous Raet1e gene as well as the Raet1e promoter in a reporter plasmid."
RAET1E affects E2F
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"Collectively, the data demonstrate that E2F transcription factors bind and transactivate the Raet1e promoter, play an important role in supporting Raet1 transcription in proliferating cells, and function potentially redundantly in driving Raet1 transcription."
RAET1E affects DUMO1
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RAET1E binds DUMO1. 1 / 1
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"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
RAET1E affects Atherosclerosis Modifier Locus Ath11 10b
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RAET1E activates Atherosclerosis Modifier Locus Ath11 10b. 1 / 1
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"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."
RAET1E affects AS1
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"According to both the data from GEPIA () and TCGA (), we unveiled that the expression of LINC01559, LINC00483, LINC01296, RAET1E-AS1 and PCED1B-AS1 was significantly high in STAD (stomach adenocarcinoma) tissues in contrast with normal gastric tissues (Fig. xref , Supplementary Fig. xref )."
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RAET1E affects ARL8B
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RAET1E affects ALG11
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"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
RAB3B affects RAET1E
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PODXL2 affects RAET1E
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PAMP affects RAET1E
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PAMP increases the amount of RAET1E. 1 / 1
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"Collectively, the presented data exclude that ULBP4 is expressed by human monocytes under normal conditions and upon activation by PAMP."
RAET1E is modified
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RAET1E is glycosylated. 1 / 1
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"Position 82 is polymorphic and occupied either by asparagine (stULBP4) or tyrosine (Uniprot reference sequence at), and therefore ULBP4 glycosylation can be expected to be variable within the human population with potential consequences for expression and detection."
NRN1 affects RAET1E
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NCR3LG1 affects RAET1E
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MKN45 cells HKHP affects RAET1E
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MKN45 cells HKHP activates RAET1E. 1 / 1
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eidos
"Stimulation of MKN45 cells with HKHP increased MICA , ULBP4 ( another NKG2DL ) , and TLR4 at the protein and transcriptional levels ."
MICA affects ULBP3
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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
MFAP3 affects RAET1E
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No evidence text available
IGDCC4 affects RAET1E
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No evidence text available
IFNGR1 affects RAET1E
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No evidence text available
HDAC3 affects RAET1E
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HDAC3 inhibits RAET1E. 1 / 1
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"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."
GOLIM4 affects RAET1E
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No evidence text available
FGFR2 affects RAET1E
1 |
1 |

No evidence text available
FGFR1 affects RAET1E
1