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NGF leads to the phosphorylation of NTRK1. 10 / 144
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"TrkA is a marker of the cholinergic cell bodies in the septum and NGF infusion in vivo elicits TrkA phosphorylation, increases the size of cholinergic neurons and stimulates Chat expression."
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"During early postnatal development in rats, these cholinergic neurons express TrkA mRNA ( Ringstedt et al., 1993 ) and moderate levels of p75 NGFR ( Koh and Loy, 1989 ), and show NGF-induced TrkA pho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NGF-induced TrkA tyrosine phosphorylation, detected using an anti-P-TrkA Y794 antibody, was diminished by adenovirus-mediated over-expression of PTP1B WT ( xref )."
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"Moreover, NGF-induced phosphorylation of TrkA and ERK was also attenuated by the transfection with a dominant-negative src construct."
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"Pretreatment with SIN-1 also resulted in a decrease in the NGF-induced phosphorylation of TrkA protein."
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"3.3 NGF salvages serum deprived NPM-ALK + T-cell lymphoma cells and induces the phosphorylation of TrkA in these cells."
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"This antibody completely blocks NGF-induced TrkA phosphorylation in septal cultures (data not shown)."
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"PACAP38 provoked an increase in basal and NGF stimulated phosphorylation of trkA."
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"The treatment of cells with NGF triggered TRKA phosphorylation at Y674 and Y675 (Figure xref ), and induced potent neurite outgrowth confirmed by immunocytochemistry for a marker of young neurons, a class III ß-tubulin (TuJ1) [ xref ] (Figure xref )."
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"NGF-induced TrkA phosphorylation and activation of MAPK are also reduced by nitrative stress caused by peroxynitrite in PC12 cells [ xref ]."
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NGF phosphorylates NTRK1 on tyrosine. 10 / 27
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"In C6-2B cells stably transfected with the rat trkA cDNA, NGF increased c-fos mRNA, induced tyrosine phosphorylation of gp140trk, and SNT (suc associated neurotrophic factor induced tyrosine phosphorylated target), and caused morphological changes within 72 h. All of these effects of NGF were blocked by the protein kinase inhibitor K-252a suggesting that NGF signal transduction was restored by trkA expression."
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"Exogenously added NGF to AEC culture rapidly induced tyrosine phosphorylation of TrkA, indicating that TrkA expressed on AEC is capable of responding to NGF and of transducing NGF signals."
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"Here we demonstrate that extended C2-ceramide exposure dramatically increases NGF induced trkA activation and further show that C2-ceramide augments trkA tyrosine phosphorylation even in the absence of neurotrophin."
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"Intraparenchymal NGF injections in adult and aged rats induce long lasting Trk tyrosine phosphorylation."
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"DHCA had no detectable effect on the Trk tyrosine phosphorylation mediated by NGF, the primary event in NGF signaling."
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"In rat pheochromocytoma (PC12) cells, nerve growth factor (NGF)-mediated tyrosine phosphorylation of TrkA stimu- lates intracellular signaling pathways that are known to include activation of Shc, pho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues."
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"NGF injection studies revealed that NGF stimulated tyrosine phosphorylation of trkA in multiple brain regions."
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"Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF."
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"In addition, GM1 potentiated the NGF mediated activation of tyrosine phosphorylation of trkA."
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NGF leads to the phosphorylation of NTRK1 on Y496. 10 / 11
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"We investigated whether this compound improved NGF induced tyrosine phosphorylation of the Y490 domain of TrkA and conserved the expression of an early gene (c-fos) in human NB cell lines (IMR-32 and NB-39)."
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"The presence of BCS totally blocked the Tyr 490 phosphorylation of TrkA stimulated by NGF (1-14) (50 muM) (P < 0.01); this effect was partially inhibited by the presence of metal ions (p < 0.05)."
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"However, the upregulation of TrkA tyrosine-490 phosphorylatin by NGF was significantly downregulated during the long-term inactivation of JNK caused by SP600125 treatment for 12 h, but not by wortmannin, suggesting a role of JNK in the maintenance of TrkA tyrosine-490 phosphorylation enhanced by NGF ( xref )."
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"NGF (50 ng/ml)-induced phosphorylation of TrkA at tyrosine 490, which is known to be the important site for the induction of MAPK and Akt signaling cascades [ xref ], was significantly enhanced by the addition of LPC (1 μM) ( xref C)."
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"These two signalling cascades are triggered by NGF-dependent phosphorylation of Y490 and Y751 residues of TrkA, which are also transphosphorylated upon FPR1 activation by N-fMLP ( xref )."
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"Nogo-A over-expression also changed NGF-induced phosphorylation of TrkA at tyrosines 490 and 674/675 from sustained to transient, and prevented the regulated intramembrane proteolysis of p75 NTR , indicating that Nogo-A was altering the function of the two neurotrophin receptors."
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"Moreover, the upregulation of TrkA tyrosine-490 phosphorylation by NGF was not altered by either wortmannin or SP600125 4 h after NGF treatment, indicating a drug specificity of SP600125 and wortmannin."
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"The Tyr-490 phosphorylation of TrkA stimulated by Ac-NGF(1–14) (50 μM) was inhibited by pre-treatment with BCS, but this effect was not restored by the presence of CuSO 4 and ZnSO 4 (Figure xref )."
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"At the molecular level, NS 1231 enhanced NGF induced signalling events, such as TrkA phosphorylation at the Shc binding site Tyr490 as well as ERK activation in PC12 cells."
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"SgG2 significantly increased NGF-dependent TrkA phosphorylation at tyrosine 490 (Tyr490) at 15 min, but not at 120 min post-incubation, when compared to control and M3 conditions ( xref )."
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NGF phosphorylates NTRK1 on Y791. 2 / 2
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"NGF induces TrkA phosphorylation on a Y785 residue, which is also transphosphorylated by FPR1 activation ( xref ) and which represents a docking site for the activation of the PLC γ 1/PKC pathway."
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"The phosphorylation of residue Tyr 785 of TrkA by NGF leads to PLC-1γ recruitment and phosphorylation."
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NGF leads to the phosphorylation of NTRK1 on Y681. 2 / 2
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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NGF leads to the phosphorylation of NTRK1 on Y680. 2 / 2
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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NGF phosphorylates NTRK1 on Y757. 1 / 1
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"These two signalling cascades are triggered by NGF-dependent phosphorylation of Y490 and Y751 residues of TrkA, which are also transphosphorylated upon FPR1 activation by N-fMLP ( xref )."
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Mutated NGF leads to the phosphorylation of NTRK1. 1 / 1
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"This was further supported by the ability of mutant NGF to phosphorylate Erk1/2, a downstream target of TrkA."
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