"In C6-2B cells stably transfected with the rat trkA cDNA, NGF increased c-fos mRNA, induced tyrosine phosphorylation of gp140trk, and SNT (suc associated neurotrophic factor induced tyrosine phosphorylated target), and caused morphological changes within 72 h. All of these effects of NGF were blocked by the protein kinase inhibitor K-252a suggesting that NGF signal transduction was restored by trkA expression."
"Addition of NGF to PC12 cells elicits rapid phosphorylation of gp140trk on tyrosine residues and stimulates its tyrosine kinase activity."
"NGF induces rapid tyrosine phosphorylation of trkA and consequent phosphorylation and activation of signal transduction substrates including extracellular signal regulated kinases (ERKs)/mitogen-activated protein kinases (MAPKs) XREF_BIBR, XREF_BIBR."
"We found that intraparenchymal NGF elicits prolonged tyrosine phosphorylation of Trk type NGF receptors."
"As expected, NGF, but not NT-3 or proNT-3, stimulated tyrosine phosphorylation of Trk A."
"NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro."
"NGF stimulated tyrosine phosphorylation of the Trk (def) + PI 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kinase in vitro and the production of PI (3,4) P2 and PI (3,4,5) P3 in vivo (comparable to wild-type)."
"NGF increased tyrosine phosphorylation of the 140-kDa protein (TrkA monomer), and preincubation with GM1 potentiated this effect."
"Exogenously added NGF induced rapid phosphorylation of TrkA tyrosine kinase."
"NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues."