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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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NGF phosphorylates NTRK1. 10 / 124
2 | 2 54 65
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"TrkA is a marker of the cholinergic cell bodies in the septum and NGF infusion in vivo elicits TrkA phosphorylation, increases the size of cholinergic neurons and stimulates Chat expression."
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"During early postnatal development in rats, these cholinergic neurons express TrkA mRNA ( Ringstedt et al., 1993 ) and moderate levels of p75 NGFR ( Koh and Loy, 1989 ), and show NGF-induced TrkA pho[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"Analogous to the findings with RCAN1 overexpression, axonal application of calcineurin inhibitors had no effect on NGF dependent phosphorylation of TrkA, Erk1/2 and Akt locally within distal axons."
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"Both NGF and DHEA strongly increased phosphorylation of TrkA as early as 10 min, an effect which was also maintained at 20 min (XREF_FIG)."
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"These studies are similar to recent findings in peripheral sensory neurons where increased surface expression of TRPV1 channels in DRG neurons is induced via NGF mediated activation of TrkA and subsequent channel phosphorylation by Src kinase."
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"NGF increased TrkA phosphorylation in hippocampal neurons and provided protection that required phosphoinositol-3-phosphate (PI3)-kinase activity and Akt phosphorylation, whereas the mitogen activated protein kinases (MAPK), extracellular regulated kinases (Erk) 1/2, were not involved."
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"NGF led to the phosphorylation of TrkA, mitogen activated protein kinase (MAPK), and p38 MAPK but not stress activated protein kinase and c-Jun NH2-terminal kinase in PANC-1 and MIA-PaCa-2 cells."
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"NGF-induced TrkA tyrosine phosphorylation, detected using an anti-P-TrkA Y794 antibody, was diminished by adenovirus-mediated over-expression of PTP1B WT ( xref )."
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"Moreover, NGF-induced phosphorylation of TrkA and ERK was also attenuated by the transfection with a dominant-negative src construct."
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"In RNCMs, recombinant NGF induced trkA phosphorylation, followed by Ser473 phosphorylation and nuclear translocation of phospho-protein kinase B (Akt)."
NGF leads to the phosphorylation of NTRK1 on tyrosine. 10 / 21
| 1 20
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"In C6-2B cells stably transfected with the rat trkA cDNA, NGF increased c-fos mRNA, induced tyrosine phosphorylation of gp140trk, and SNT (suc associated neurotrophic factor induced tyrosine phosphorylated target), and caused morphological changes within 72 h. All of these effects of NGF were blocked by the protein kinase inhibitor K-252a suggesting that NGF signal transduction was restored by trkA expression."
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"Addition of NGF to PC12 cells elicits rapid phosphorylation of gp140trk on tyrosine residues and stimulates its tyrosine kinase activity."
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"NGF induces rapid tyrosine phosphorylation of trkA and consequent phosphorylation and activation of signal transduction substrates including extracellular signal regulated kinases (ERKs)/mitogen-activated protein kinases (MAPKs) XREF_BIBR, XREF_BIBR."
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"We found that intraparenchymal NGF elicits prolonged tyrosine phosphorylation of Trk type NGF receptors."
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"As expected, NGF, but not NT-3 or proNT-3, stimulated tyrosine phosphorylation of Trk A."
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"NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro."
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"NGF stimulated tyrosine phosphorylation of the Trk (def) + PI 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kinase in vitro and the production of PI (3,4) P2 and PI (3,4,5) P3 in vivo (comparable to wild-type)."
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"NGF increased tyrosine phosphorylation of the 140-kDa protein (TrkA monomer), and preincubation with GM1 potentiated this effect."
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"Exogenously added NGF induced rapid phosphorylation of TrkA tyrosine kinase."
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"NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues."
NGF leads to the phosphorylation of NTRK1 on Y496. 10 / 10
| 7 3
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"We investigated whether this compound improved NGF induced tyrosine phosphorylation of the Y490 domain of TrkA and conserved the expression of an early gene (c-fos) in human NB cell lines (IMR-32 and NB-39)."
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"Nogo-A over-expression also changed NGF-induced phosphorylation of TrkA at tyrosines 490 and 674/675 from sustained to transient, and prevented the regulated intramembrane proteolysis of p75 NTR , indicating that Nogo-A was altering the function of the two neurotrophin receptors."
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"NGF (50 ng/ml)-induced phosphorylation of TrkA at tyrosine 490, which is known to be the important site for the induction of MAPK and Akt signaling cascades [ xref ], was significantly enhanced by the addition of LPC (1 μM) ( xref C)."
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"The Tyr-490 phosphorylation of TrkA stimulated by Ac-NGF(1–14) (50 μM) was inhibited by pre-treatment with BCS, but this effect was not restored by the presence of CuSO 4 and ZnSO 4 (Figure xref )."
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"The presence of BCS totally blocked the Tyr 490 phosphorylation of TrkA stimulated by NGF (1-14) (50 muM) (P < 0.01); this effect was partially inhibited by the presence of metal ions (p < 0.05)."
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"Moreover, the upregulation of TrkA tyrosine-490 phosphorylation by NGF was not altered by either wortmannin or SP600125 4 h after NGF treatment, indicating a drug specificity of SP600125 and wortmannin."
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"However, the upregulation of TrkA tyrosine-490 phosphorylatin by NGF was significantly downregulated during the long-term inactivation of JNK caused by SP600125 treatment for 12 h, but not by wortmannin, suggesting a role of JNK in the maintenance of TrkA tyrosine-490 phosphorylation enhanced by NGF ( xref )."
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"At the molecular level, NS 1231 enhanced NGF induced signalling events, such as TrkA phosphorylation at the Shc binding site Tyr490 as well as ERK activation in PC12 cells."
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"SgG2 significantly increased NGF-dependent TrkA phosphorylation at tyrosine 490 (Tyr490) at 15 min, but not at 120 min post-incubation, when compared to control and M3 conditions ( xref )."
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"NGF-induced phosphorylation of trkA at Y490 provides a recruitment site for binding of the adaptor protein Shc."
NGF leads to the phosphorylation of NTRK1 on Y681. 2 / 2
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
NGF leads to the phosphorylation of NTRK1 on Y680. 2 / 2
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
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"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
NGF phosphorylates NTRK1 on Y791. 2 / 2
| 1 1
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"The phosphorylation of residue Tyr 785 of TrkA by NGF leads to PLC-1γ recruitment and phosphorylation."
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"The phosphorylation of residue Tyr 785 of TrkA by NGF leads to PLC-1gamma recruitment and phosphorylation."