IndraLab

Statements

NGF phosphorylates NTRK1 on tyrosine. 27 / 27
| 26 1
reach
"In C6-2B cells stably transfected with the rat trkA cDNA, NGF increased c-fos mRNA, induced tyrosine phosphorylation of gp140trk, and SNT (suc associated neurotrophic factor induced tyrosine phosphorylated target), and caused morphological changes within 72 h. All of these effects of NGF were blocked by the protein kinase inhibitor K-252a suggesting that NGF signal transduction was restored by trkA expression."
7868185
reach
"Exogenously added NGF to AEC culture rapidly induced tyrosine phosphorylation of TrkA, indicating that TrkA expressed on AEC is capable of responding to NGF and of transducing NGF signals."
14706643
reach
"Here we demonstrate that extended C2-ceramide exposure dramatically increases NGF induced trkA activation and further show that C2-ceramide augments trkA tyrosine phosphorylation even in the absence of neurotrophin."
10098845
reach
"Intraparenchymal NGF injections in adult and aged rats induce long lasting Trk tyrosine phosphorylation."
8635559
reach
"DHCA had no detectable effect on the Trk tyrosine phosphorylation mediated by NGF, the primary event in NGF signaling."
9281586
reach
"In rat pheochromocytoma (PC12) cells, nerve growth factor (NGF)-mediated tyrosine phosphorylation of TrkA stimu- lates intracellular signaling pathways that are known to include activation of Shc, pho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7671302
sparser
"NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues."
1844238
reach
"NGF injection studies revealed that NGF stimulated tyrosine phosphorylation of trkA in multiple brain regions."
8572656
reach
"Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF."
1706478
reach
"In addition, GM1 potentiated the NGF mediated activation of tyrosine phosphorylation of trkA."
7790879
reach
"The development of TrkA function in the neostriatum appears to start somewhere between P0 and P7, since NGF can induce TrkA tyrosine kinase phosphorylation in neostriatal tissue in vitro from P7 but n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9704891
reach
"As expected, NGF, but not NT-3 or proNT-3, stimulated tyrosine phosphorylation of Trk A."
19940174
reach
"NGF increased tyrosine phosphorylation of the 140-kDa protein (TrkA monomer), and preincubation with GM1 potentiated this effect."
9166727
reach
"Exogenously added NGF induced rapid phosphorylation of TrkA tyrosine kinase."
14706643
reach
"BDNF stimulated much stronger interactions of PLCgamma with Trk than NGF and NT-3 in PC12 cells stably expressing TrkB and cultured cerebral cortical neurons, respectively, although BDNF, NGF and NT-3 induced similar levels of tyrosine phosphorylation of Trk."
12419535
reach
"We found that NGF caused tyrosine phosphorylation of TrkA, resulting in a sustained Ca (2+) mobilization, NFAT activation, extracellular-signal regulated kinase (ERK) phosphorylation, and chemokine, macrophage inflammatory protein-1beta (MIP-1beta) production."
15153516
reach
"Although we detected a low level of phosphorylation of these receptors in the absence of NGF, TrkA tyrosine phosphorylation was dramatically increased by NGF treatment."
12124278
reach
"Only at the highest dose of 4.5 ug did intracerebroventricularly applied NGF elicit significant Trk tyrosine phosphorylation."
8637432
reach
"NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues."
1844238
reach
"Immunoprecipitation of lysates from naive and NGF treated PC12 cells (100 ng/ml NGF for 5 min, with or without 50 muM BB), followed by SDS-PAGE, Western blotting and immunoreaction with anti-phosphoty[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10727719
reach
"Addition of NGF to PC12 cells elicits rapid phosphorylation of gp140trk on tyrosine residues and stimulates its tyrosine kinase activity."
1849459
reach
"NGF induces rapid tyrosine phosphorylation of trkA and consequent phosphorylation and activation of signal transduction substrates including extracellular signal regulated kinases (ERKs)/mitogen-activated protein kinases (MAPKs) XREF_BIBR, XREF_BIBR."
22140566
reach
"We found that intraparenchymal NGF elicits prolonged tyrosine phosphorylation of Trk type NGF receptors."
8637432
reach
"NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro."
9671662
reach
"NGF stimulated tyrosine phosphorylation of the Trk (def) + PI 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kinase in vitro and the production of PI (3,4) P2 and PI (3,4,5) P3 in vivo (comparable to wild-type)."
10467403
reach
"5min NGF exposure induced the tyrosine phosphorylation of TrkA at Tyr680 and Tyr681 (Tyr674 and Tyr675 on human TrkA isoform)."
30808933
reach
"These data demonstrate that NGF caused tyrosine phosphorylation of TrkA to induce chemokine production in HMC-1 cells via a pathway that mainly depends on sustained Ca (2+) mobilization and NFAT activation."
15153516