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NGF phosphorylates NTRK1. 200 / 209
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"NGF-induced phosphorylation of TrkA and mitogen-activated protein kinase was significantly diminished in the necdin-null sensory ganglia."
16049186
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"Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF."
1706478
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"Furthermore, Aβ abrogates the NGF-induced tyrosine phosphorylation and polyubiquitination of TrkA in PC12 cells and human hippocampal tissues, and hence, deactivates the downstream Ras/MAPK and PI3K/Akt signaling pathways [ xref ]."
36291068
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"Because inhibition of endogenous SHP-1 stimulates the NGF independent phosphorylation of TrkA, SHP-1 can regulate the basal, nonliganded activity of TrkA."
14662744
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"Further evidence that EGFR and TrkA exert some of their effects by engagement of GPCR-signalling molecules was provided by the fact that PTX inhibits EGF-induced EGFR phosphorylation and ROS productio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20566383
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"As previously reported, while exposure to K-252a inhibited NGF-induced p-TrkA levels ( xref , xref ), co-treatment with 17-DMAG and K-252a produced further decline in the NGF-induced phosphorylation of TrkA ( xref )."
20663926
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"Intriguingly, it was reported that tamoxifen, prescribed to breast cancer patients, may inhibit TrkA NGF phosphorylation and, respectively, the NGF-elicited proliferation of epithelial cells from breast cancer [ xref ]."
39065809
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"NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro."
9671662
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"The treatment of cells with NGF triggered TRKA phosphorylation at Y674 and Y675 (Figure xref ), and induced potent neurite outgrowth confirmed by immunocytochemistry for a marker of young neurons, a class III ß-tubulin (TuJ1) [ xref ] (Figure xref )."
29312610
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"Specifically, NGF enhanced TrkA phosphorylation, PI3K activity, and Akt phosphorylation."
17666398
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"We found that in neurons treated with monensin, higher concentrations of NGF were required to elicit similar levels of phosphorylation of TrkA and the downstream signaling effectors Akt and Erk1/2 seen in control neurons (XREF_FIG)."
19759314
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"Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells."
14988025
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"Immunoblotting analyses with a phospho specific antibody revealed that NGF increased TrkA phosphorylation at the PLC-gamma interaction site (Y794), as compared to untreated control cultures, or cultures treated with NT-3 (XREF_FIG)."
21689596
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"Furthermore, they reported that Cav-1 scaffolding domain peptide could suppress the NGF-induced phosphorylation of TrkA as well as activity of MAPK in porcine oligodendrocytes ( Schmitz et al., 2010 )[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21693146
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"NGF caused a robust increase of TrkA phosphorylation after 10 min, whereas the TrkA phosphorylation by epinephrine was considerably delayed compared with NGF treatment and required at least 60 min."
17215105
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"Consistent with previous reports ( Howe et al., 2001 ), TrkA receptor phosphorylation induced by NGF was decreased by K252a pretreatment."
18930432
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"NGF salvages serum‐deprived NPM‐ALK + T‐cell lymphoma cells and induces the phosphorylation of TrkA in these cells."
28557340
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"Then, we set to examine whether NGF induces the phosphorylation of TrkA in NPM‐ALK + T‐cell lymphoma."
28557340
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"We investigated whether this compound improved NGF induced tyrosine phosphorylation of the Y490 domain of TrkA and conserved the expression of an early gene (c-fos) in human NB cell lines (IMR-32 and NB-39)."
17409494
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"Moreover, NGF-induced phosphorylation of TrkA and ERK was also attenuated by the transfection with a dominant-negative src construct."
14988025
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"To study the effect of the deletion, we used three functional assays: binding to NGF, activation of TrkA phosphorylation by NGF, and differentiation of PC12 cells with the TrkA/NGF system."
35601915
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"NGF induces the auto phosphorylation and activation of TrkA [33] ."
26476374
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"In PC12 cells, a depletion of membrane cholesterol decreased the magnitude and duration of NGF stimulated p42/44 MAPK as well as the phosphorylation of TrkA."
22740150
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"Given that many NGF effects are mediated by activation of its receptor TrkA and downstream signaling kinases such as MAPKs and PI3K/AKT, we examined whether L5 weakens NGF-induced TrkA phosphorylation and resultant activation of MAPKs (ERK, JNK, and p38) and Akt in PC12 cultures."
28800073
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"We demonstrate that the constitutively active Src facilitates NGF-induced phosphorylation of TrkA, causing enhancement of the mitogen-activated protein kinase (MAPK) signaling."
14988025
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"However, and surprisingly, we found that TrkA phosphorylation induced by NGF was absent in APP YG/YG mice (XREF_FIG, bottom panel)."
21849536
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"NGF-induced tyrosine phosphorylation of phospholipase Cgamma, TrkA, and Shc was unaltered in the Shb-overexpressing cells, whereas that of Shb was greatly enhanced in these cells compared with control PC12-neo cells."
9751119
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"In conclusion, we have demonstrated that NGF induces Cl − conductance in a time-dependent manner and that Cl − channel inhibitors suppress NGF-induced TrkA phosphorylation and the subsequent activatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20144672
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"In this study we found that NEAP/DUSP26 expression decreased TrkA and FGFR1 phosphorylation induced by NGF and, conversely, knockdown of NEAP enhanced TrkA and FGFR1 activation."
28701747
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"The phosphorylation of TrkA by NGF at axon tips initiates diverse signals for metabolic regulation."
35775136
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"NGF led to the phosphorylation of TrkA, mitogen activated protein kinase (MAPK), and p38 MAPK but not stress activated protein kinase and c-Jun NH2-terminal kinase in PANC-1 and MIA-PaCa-2 cells."
11205897
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"These findings suggested that elevated NGF levels in the myocardium and circulation contribute to TRKA phosphorylation in tumor tissue, potentially hastening tumor growth in mice with MI-induced heart failure."
39634266
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"Moreover, 5 min of NGF stimulation after IFN-gamma treatment caused the phosphorylation of TrkA protein and downstream proteins."
10842245
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"During early postnatal development in rats, these cholinergic neurons express TrkA mRNA ( Ringstedt et al., 1993 ) and moderate levels of p75 NGFR ( Koh and Loy, 1989 ), and show NGF-induced TrkA pho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9704891
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"The development of TrkA function in the neostriatum appears to start somewhere between P0 and P7, since NGF can induce TrkA tyrosine kinase phosphorylation in neostriatal tissue in vitro from P7 but n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9704891
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"At a concentration of 10 ng/ml, NGF induced greater phosphorylation of TrkA (p-TrkA) and AKT in TrkA/p75 cells than in TrkA alone ( xref )."
21419569
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"The NGF-induced phosphorylation of TrkA and ERK1/2 was enhanced in a dose-dependent manner ( Fig. 2B )."
14988025
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"NGF treatment caused a rapid phosphorylation of trkA (NGFR) in HUVECs, determining a parallel increase of phosphorylated ERK1/2."
12154004
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"Antisense knockdown of RabGEF1 expression reduces NGF-induced TrkA phosphorylation but not its internalization."
26588713
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"The Western blots revealed that NGF and DTT but not Dox induce TrkA phosphorylation in TrkA SH-SY5Y cells ( xref c)."
36142807
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"Tyrosine residues at 490 and 670/674/674 of TrkA were rapidly phosphorylated after the NGF treatment ( Fig. 4 ); however, in the presence of the Cl − channel inhibitors, NPPB and SITS, the NGF-induced[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20144672
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"As previously described, NGF induced an increase in TrkA and P38 phosphorylation [19] (Fig. 2a)."
27576911
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"The NGF-induced TrkA phosphorylation at both 490 and 670/674/675 was completely suppressed in the presence of BAPTA ( Fig. 4 B)."
20144672
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"Surprisingly, we found little apoptosis (≤25%) in neurons provided 50 ng/ml NGF and 200 nM K252a and K252a did not significantly affect the anti-apoptotic effect of ceramide ( Fig. 6D ) although it co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14614956
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"To determine whether NRP1 controls NGF-stimulated phosphorylation of TrkA, a proximal and necessary component of TrkA signaling, dissociated mouse DRG neurons were stained with a phospho-specific antibody to TrkA Y785 (equivalent to Y791 in human TrkA)."
39589827
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"NTRK1, a neurotrophic tyrosine kinase receptor, is phosphorylated in response to NGF [6,7] ."
18077166
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"In this report, we provide preliminary evidence that overexpression of the human wildtype ortholog of Car8 (CA8 WT ), but not the reported CA8 S100P loss-of-function mutation (CA8 MT ); inhibits nerve growth factor (NGF)-induced phosphorylation of ITPR1, TrkA (NGF high affinity receptor); and ITPR1-mediated cytoplasmic free calcium release in vitro."
29789638
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"The lack of palmitoylation had no effect on the ability of p75 to enhance the short-term NGF-induced tyrosine phosphorylation of TrkA over a wide range of NGF concentrations."
11020215
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"We show for the first time that CA8 overexpression inhibited NGF-stimulated ITPR1 and TrkA phosphorylation, and ITPR1-mediated calcium release in vitro."
29789638
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"In compartmentalized cultures, NGF treatment of distal axons (100ngperml, 8h) resulted in the robust phosphorylation of TrkA receptors and of canonical signalling effectors, Erk1/2 and Akt, locally within distal axons in both RCAN1- and GFP expressing neurons."
26658127
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"Analogous to the findings with RCAN1 overexpression, axonal application of calcineurin inhibitors had no effect on NGF dependent phosphorylation of TrkA, Erk1/2 and Akt locally within distal axons."
26658127
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"Compounds 1 and 3 Enhanced NGF-Induced TrkA and Erk1/2 Phosphorylation in PC12 Cells."
28758954
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"Rab7 CMT2B mutants expressing PC12 cells show differential TrkA phosphorylation following NGF stimulation."
21151572
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"But the time window of TrkA phosphorylation induced by CB-NGF and NGF was different."
18585441
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"Later, linear cell-penetrating peptides, synthesised as HIV Tat fusions, were shown to inhibit NGF-stimulated TrkA phosphorylation and to suppress NGF-induced TRPV1 expression in PC12 cells xref ."
30700786
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"However, the addition of NGF (50 ng/ml) increased Trk phosphorylation by 40-fold, an extent significantly greater than in control cells ( Fig. 4 A)."
24333329
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"NGF 5 ng/mL triggered TrkA phosphorylation in PC12 cells ( Fig. 3 B); however, none of the test compounds could cause any detectable phosphorylation in TrkA receptor."
28495385
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"In this sense, antibodies against p75 NTR reduced NGF-mediated TrkA phosphorylation in PC12 cells and primary neurons, whereas the co-expression of p75 NTR and TrkA in heterologous expression systems [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21978666
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"In this reversed experiment, both NGF-induced TrkA and FGFR1 Tyr phosphorylation (normalized by receptor levels) were elevated in PC12-shNEAP cells in comparison to those in PC12-pSuper control cells (Fig.  xref )."
28701747
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"Inhibiting TrkA by MNAC13 effectively suppressed the increased phosphorylation of TrkA induced by NGF and the NGF stimulated growth in ISC derived organoids."
30988299
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"Consistent with previous reports ( Howe et al., 2001 ), TrkA receptor phosphorylation induced by NGF was decreased by K252a pretreatment."
18930432
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"For example, NGF stimulates TrkA phosphorylation in vitro in human keratinocytes, and their proliferation through apoptosis inhibition [50,70,71] ."
26920228
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"Neurite outgrowth in PC12 cells depends on NGF mediated binding and activation and phosphorylation of the TrkA receptor and downstream signaling events leading to new gene expression."
21849477
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"Instead the mimicking peptides NGF(1–14) and dNGF(1–15) induced exclusively TrkA phosphorylation, an effect strongly influenced by copper ions."
31638089
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"NGF activates the high-affinity receptor tropomyosin receptor kinase A (TrkA), increasing phosphorylation and activity of TRPV1 channels."
35490907
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"In this study we found that NEAP and DUSP26 expression decreased TrkA and FGFR1 phosphorylation induced by NGF and, conversely, knockdown of NEAP enhanced TrkA and FGFR1 activation."
28701747
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"As expected, NGF promoted TrkA phosphorylation [ xref ]."
25611061
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"In these B cells, NGF failed to induce Trk A phosphorylation, cytoskeleton assembly, or MAP kinase activation."
15163901
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"As expected, NGF and BDNF both promoted Akt and Erk phosphorylation in TrkA and TrkB-expressing MG87 fibroblasts, respectively (Figures xref )."
28680400
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"There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [ xref ]."
20482876
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"Preincubation with SgG2 did not affect NGF dependent TrkA or ERK phosphorylation ( xref ) and, in agreement with xref , changes on signaling were detected only when SgG2 was added together with NGF."
25611061
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"Our study reveals that lipid A in LPS markedly enhanced NGF-induced phosphorylation of TrkA upon binding to TrkA."
39589893
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"Nor did BPA affect NGF-induced phosphorylation of MEK1/2, which is a MAPK upstream of ERK1/2 ( Fig. 7 C and D), or the NGF-induced phosphorylation of TrkA, which is a receptor for NGF ( Fig. 7 E)."
21871873
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"Furthermore, clivorine reduced the NGF induced the phosphorylations of TrkA, protein kinase B and cAMP response element binding protein in cultured PC12 cells."
27387401
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"NGF‐induced phosphorylation of TrkA and MAPK is diminished in Ndn‐null DRG explants (Figure  xref )."
34338396
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"Mechanistically, lipid A in LPS binding to TrkA enhanced NGF-induced TrkA phosphorylation, synergistically stimulating mast cells to release neurotrophin-3 (NT3), thereby promoting MSC chondrogenic differentiation in situ."
39589893
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"Moreover, in cells lacking endogenous GM1, NGF did not induce the auto‐phosphorylation of TrkA, but the rescue of GM1 content restored the responsiveness of TrkA to its ligand [ xref ]."
36638010
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"Mouse and pig aortic endothelial cells produce NGF, express both NGF receptors TrkA and p75, exogenously added NGF induced rapid phosphorylation of TrkA and pig aortic endothelial cells migrated when [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17764704
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"Pretreatment with SIN-1 also resulted in a decrease in the NGF-induced phosphorylation of TrkA protein."
11169611
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"Levels of TrkA receptor phosphorylation and downstream ERK activation induced by NGF were not influenced by GnT-VB expression."
16606368
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"MS-430 also prolonged the NGF induced phosphorylation of MAPK, but the phosphorylation of TrkA induced by NGF was not affected by MS-430."
9538224
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"Indeed, MNAC13 effectively inhibited the NGF-induced phosphorylation of TrkA and Akt in 3T3 cells expressing TrkA, but did not suppress the phosphorylation of TrkB/C induced by BDNF and NT-3 in 3T3 cells expressing TrkB/C (Supplementary Fig.  xref )."
30988299
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"NTRK1, a neurotrophic tyrosine kinase receptor, is phosphorylated in response to NGF [6,7] and mutations in NTRK1 have been associated with HSAN IV [8] ."
16373086
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"MS-430 also prolonged the NGF-induced phosphorylation of MAPK, but the phosphorylation of TrkA induced by NGF was not affected by MS-430."
9538224
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"Approximately equivalent levels of soluble versus immobilized ligand were applied based on our previous assessments of TrkA phosphorylation by the NGF microparticles."
17785519
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"NGF induces autophosphorylation of tyrosine residues on the trkA receptor, phosphorylation of signaling molecules of MAPK/ERK and PI3K/Akt pathways, activation of gene transcription and rearrangement [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33798505
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"This antibody completely blocks NGF-induced TrkA phosphorylation in septal cultures (data not shown)."
20554873
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"In particular, the inhibition of EGFR prevented the ligand dependent responses mediated by the other two receptors, while the inhibition of FPR abolished the EGFR and TrkA phosphorylation induced by EGF and NGF, respectively."
22251451
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"In addition, monoamine activated alpha1M enhanced the NGF promoted TrkA phosphorylation and up-regulated the expression of NGF inducible immediate-early genes (c-jun and NGFI-A) and delayed response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect."
10617108
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"To identify the cellular component (s) at which LPC acts to potentiate NGF-TrkA signal, we examined the phosphorylation of MEK and TrkA, and found that LPC enhances TrkA phosphorylation induced by NGF."
23772401
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"Surprisingly, the antiestrogen drug tamoxifen (TAM) inhibited NGF induced MCF-7 cell proliferation and trkA (NGFR) phosphorylation in a concentration related fashion."
11306479
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"The developmentally reduced ability of BDNF to induce TrkB phosphorylation in the mouse brain microslices is probably not due to reduced penetrance of BDNF into mature brain tissue since a highly related neurotrophin, NGF (nerve growth factor), readily induced TrkA phosphorylation (Y674/5) in hippocampal microslices obtained from P24 mice (XREF_FIG)."
22396798
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"NGF causes the phosphorylation of TrkA on many sites, including one that allows it to recruit and activate PLCgamma."
27503831
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"TrkA phosphorylation and activation by NGF is enhanced when p75 NTR is present [ xref ]."
39598254
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"Moreover, in cells lacking endogenous GM1, NGF did not induce the auto‐phosphorylation of TrkA, but the rescue of GM1 content restored the responsiveness of TrkA to its ligand [40]."
36638010
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"ACAF4 and ACAF12 were also tested for their ability to potentiate NGF-induced TrkA phosphorylation, but their concomitant incubation with NGF did not induce any alteration in the phosphorylation level[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28495385
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"As shown in Fig. 4 A, NGF rapidly phosphorylated TrkA at 30 min after NGF addition in both MIAPaCa-2 and PANC-1 cells, whereas KK5101 significantly inhibited phosphorylation of TrkA and its downstream[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29605512
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"Under identical conditions, a closely related neurotrophin NGF readily induced phosphorylation of its receptor TrkA in brain microslices prepared from mature brain tissues, suggesting that the dramatic reduction in the responsiveness of TrkB to BDNF in a mature tissue is not related to a reduced penetrance of the neurotrophin or to any general unsuitability of the assay for adult brain tissues."
22396798
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"NGF-induced TrkA tyrosine phosphorylation, detected using an anti-P-TrkA Y794 antibody, was diminished by adenovirus-mediated over-expression of PTP1B WT ( xref )."
28919207
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"NGF-dependent trkA phosphorylation was significantly enhanced by the presence of the peptide, whereas high-affinity binding of 125I-NGF, both NGF receptors mRNA and protein expression, and trkA dimer/monomer ratios were not influenced."
9603197
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"NGF can cause phosphorylation of TrkA."
16181609
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"When we examined the effect of Nogo-A overexpression on NGF-induced phosphorylation at two of these sites, tyrosines 490 and 674/675, which are responsible for the recruitment of adapter proteins and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29325876
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"Further, none of the test compounds increased NGF-induced TrkA phosphorylation."
28495385
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"Our results demonstrate that elevated levels of NGF are not sufficient to induce TrkA phosphorylation in non-Tg and TgCRND8 mice at 90 min following MRIgFUS alone."
32010781
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"NGF can cause phosphorylation of TrkA."
16181609
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"Even when caffeate esters were applied together with NGF, they did not increase TrkA phosphorylation induced by NGF."
30562988
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"Similarly to what was observed for PC12 cells, even when caffeate esters were added in addition to NGF, they did not increase NGF-induced TrkA phosphorylation."
30562988
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"Each mutation was systematically analyzed for TRKA glycosylation states, intracellular and cell membrane expression patterns, nerve growth factor stimulated TRKA autophosphorylation, TRKA-Y496 phosphorylation, PLCgamma activity, and neurite outgrowth."
27676246
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"The results of western blot analysis clearly show that NGF stimulated TrkA phosphorylation on several tyrosine sites, including tyrosine 490, 674/675, and 785 (Fig.  xref )."
31694615
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"As expected in cultured PC12 cells, the applied NGF-induced Trk phosphorylation in a dose-dependent manner ( xref )."
35754681
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"NRP1 knockdown blunts NGF-stimulated TrkA phosphorylation, kinase signaling and transcription, whereas NRP1 overexpression enhances signaling."
38106002
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"NGF induced similar levels of TRK-A phosphorylation in control PC12 cells and in those lacking ARAF, but the duration of the RAS-ERK signal was shortened in the latter (Figure S5A)."
35613620
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"NGF application to the distal process compartment activated local pro-survival TrkA phosphorylation and signaling diffusion to the cell bodies within 1 min from the beginning of the treatment, precedi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26778332
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"The phosphorylation of TrkA by NGF at axon tips initiates diverse signals for metabolic regulation."
35775136
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"NGF-induced TrkA phosphorylation and activation of MAPK are also reduced by nitrative stress caused by peroxynitrite in PC12 cells [ xref ]."
34440751
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"In addition, GM1 potentiated the NGF mediated activation of tyrosine phosphorylation of trkA."
7790879
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"NGF-induced NTRK1 activation causes ABL1 (c-Abelson kinase 1 or c-Abl)–mediated phosphorylation of the adaptor protein Crk at Tyr 222 , resulting in the dissociation of paxillin and c-Abl from Crk ( xref ), which is critical for NGF-induced neurite out-growth ( xref )."
22126966
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"Alternatively, it cannot be ruled out that the survival maintained in the presence of K252a reflects a yet-uncharacterized Trk-independent survival mechanism, perhaps involving pro-survival signaling [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14573392
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"As shown in Fig. 4 A, NGF rapidly phosphorylated TrkA at 30 min after NGF addition in both MIAPaCa-2 and PANC-1 cells, whereas KK5101 significantly inhibited phosphorylation of TrkA and its downstream[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29605512
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"We show for the first time that CA8 overexpression inhibited NGF-stimulated ITPR1 and TrkA phosphorylation, and ITPR1-mediated calcium release in vitro ."
29789638
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"Moreover, mice with myocardial infarction exhibited increased tumor progression caused by elevated levels of NGF, which phosphorylated TrkA and activated the PI3K/AKT signaling pathway."
39825376
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"Our data showed that cavtratin suppresses the NGF-induced phosphorylation of TrkA as well as the activation of MAPK in porcine oligodendrocytes significantly."
21523467
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"Therefore, we conclude that while the rapid retrograde TrkA phosphorylation induced in the cell bodies by NGF at the distal axons likely serves other signaling functions, it is not necessary for the r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14573392
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"NGF (3 pM) induced TrkA receptor phosphorylation within 10 s; it reached a plateau at 30 s to 15 min and decreased after 30 min."
16091303
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"To study the effect of the deletion, we used three functional assays: binding to NGF, activation of TrkA phosphorylation by NGF, and differentiation of PC12 cells with the TrkA/NGF system."
35601915
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"NT-3 [XREF_BIBR - XREF_BIBR], but not NGF [XREF_BIBR, XREF_BIBR], stimulates Trk phosphorylation and downstream signaling in rat primary cortical neurons."
26223799
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"NGF at low level induced the phosphorylations of TrkA (~ 140 kDA), Erk1/2 (~ 44/42kDa), and Akt (~ 60kDa) within 5min (XREF_FIG)."
22761636
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"3.3 NGF salvages serum deprived NPM-ALK + T-cell lymphoma cells and induces the phosphorylation of TrkA in these cells."
28557340
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"Then, we set to examine whether NGF induces the phosphorylation of TrkA in NPM-ALK + T-cell lymphoma."
28557340
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"When NGF activates TrkA phosphorylated TrkAPPFRS2α PROTAC binds to FRS2α and inhibits the downstream signaling.The first evidence of in vivo use of PROTACs was demonstrated by using a phosphoPROTAC (ErB2PPPI3K) molecule for induced knockdown of phosphoinositide 3-kinase (PI3K) protein when stimulated by growth factors."
38213543
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"It is known that NGF activates PDK1, which phosphorylates PKC, via phosphorylation of TrkA, and TPA, OAG, and DG activate the phosphorylated PKC."
21740889
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"If NGF-induced TrkA activation is dependent on Neu1 sialidase activity, then neuraminidase inhibitor like Tamiflu should have an inhibitory effect on NGF-induced phosphorylation of TrkA (pTrkA) in Trk[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347965
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"Although P28L strongly decreased NGF-induced phosphorylation of TrkA and the phosphorylation of the downstream kinase Akt (without affecting the phosphorylation of ERK1/2), the neighboring R26Q mutati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20472890
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"NGF treatment produced phosphorylation of TrkA in choroidal and retinal endothelial cells."
14614965
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"At the molecular level, NS 1231 enhanced NGF induced signalling events, such as TrkA phosphorylation at the Shc binding site Tyr490 as well as ERK activation in PC12 cells."
12067229
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"Our data provide evidence that orthovanadate could mimic NGF mediated phosphorylation of the TrkA receptor.To investigate whether NGF was required for the neuroprotective effect of orthovanadate we em[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15209419
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"Mutations in the TrkA gene cause a related disorder, HSAN IV, which produces a phenotype similar to HSAN V. xref These TrkA gene mutations result in defective binding of NGF to TrkA and, as a result, the inhibition of NGF-induced TrkA phosphorylation and downstream signaling cascades. xref "
32547184
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"Overall, our data provide strong evidence that orthovanadate could mimic NGF mediated phosphorylation of the TrkA receptor by preventing the dephosphorylation of the TrkA receptor in rat hippocampal n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15209419
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"Interestingly, NGF was more efficient in the induction of Trk and Akt phosphorylation, thus, NGF significantly increased Trk phosphorylation, in comparison with trimmed ganglia, from 15 ± 1 to 40 ± 1% of neurons ( p < 0.0001), whereas Akt phosphorylation increased from 10 ± 1 to 41 ± 1% of neurons ( p < 0.0001)."
28744222
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"CTB treatment (1 micrograms/ml) enhanced NGF-induced neurite outgrowth from PC12 cells, NGF-induced activation of ribosomal protein S6 kinase, and NGF-induced stimulation of trk phosphorylation."
8455041
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"NRP1 knockdown blunts NGF-stimulated TrkA phosphorylation, kinase signaling and transcription, whereas NRP1 overexpression enhances signaling."
38106002
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"Depletion of cholesterol resulted in an increased basal level of MAPK activity, but inhibited the activation of MAPK by TrkA, although not affecting NGF-induced phosphorylation of TrkA."
18949068
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"Furthermore, the knockdown of EGFR by siRNA abolishes NGF-induced TrkA phosphorylation (tyrosine 490) and reciprocal siTrkA abolishes EGF-induced EGFR phosphorylation [ xref ]."
37046604
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"NGF induces phosphorylation of its high-affinity receptor tropomyosin-related kinase A (TrkA), leading to the activation of the MAPK/ERK signaling pathway, which promotes CRC metastasis [ xref ]."
37610689
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"In RNCMs, recombinant NGF induced trkA phosphorylation, followed by Ser473 phosphorylation and nuclear translocation of phospho-protein kinase B (Akt)."
17992191
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"First, we evaluated whether ligand-dependent phosphorylation of its cognate receptor was dependent upon a crosstalk with another receptor: EGF-induced EGFR phosphorylation is decreased when TrkA or FP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20566383
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"TrkA is a marker of the cholinergic cell bodies in the septum and NGF infusion in vivo elicits TrkA phosphorylation, increases the size of cholinergic neurons and stimulates Chat expression."
20554873
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"According to the same researchers, NGF deprivation is also linked to NGF-independent phosphorylation of TrkA, which results much higher than that observed in the presence of NGF."
24835196
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"In addition, mechanistic studies suggested that SCGs reinforced the NGF-induced phosphorylation of TrkA, coupled with ERK1/2 activation, triggering the activation of cAMP response element-binding protein (CREB) that results in a marked increase in BDNF expression."
37623732
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"In this report, we demonstrate for the first time that NGF induces TrkA and CD44 interaction independent of TrkA phosphorylation in cancer cells."
25840418
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"Albanese's group xref , xref , xref reported compound 12 (milciclib, PHA-848125) as a dual inhibitor of cyclin-dependent kinase (CDK-2)/TRKA ( xref ), which can effectively inhibit NGF-induced TRKA phosphorylation and downstream signaling in DU-145 human prostate cancer cells with IC 50 values of 53 and 45 nmol/L, respectively."
33643817
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"Application of nerve growth factor (NGF) covalently cross linked to beads increased the phosphorylation of TrkA and Akt, but not of mitogen activated protein kinase, in cultured rat sympathetic neurons."
11799202
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"NGF stimulation of sympathetic axons resulted in a striking increase in phosphorylation of TrkA receptors derived from the soma surface (XREF_FIG)."
28919207
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"Moreover, NGF caused a rapid phosphorylation of TrkA that was prevented by selective inhibitor k252a and NGF expression is increased in serum-deprived HUVECs, suggesting that NGF upregulation may be a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17764704
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"In particular, the inhibition of EGFR prevented the ligand-dependent responses mediated by the other two receptors, while the inhibition of FPR abolished the EGFR and TrkA phosphorylation induced by EGF and NGF, respectively."
22251451
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"Therefore, we conclude that while the rapid retrograde TrkA phosphorylation induced in the cell bodies by NGF at the distal axons likely serves other signaling functions, it is not necessary for the r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14573392
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"This action is associated with the stimulation of nerve growth factor (NGF) synthesis and subsequently increased phosphorylation of the TrkA receptor by NGF, leading to the activation of ERK and Akt signaling pathways."
37958943
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"In contrast, NGF and NT-3-mediated phosphorylation of TrkA and TrkC, respectively, do not require cAMP."
25064589
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"The Western blots revealed that NGF and DTT but not Dox induce TrkA phosphorylation in TrkA SH-SY5Y cells (Figure 7c)."
36142807
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"Also, the NGF-induced TrkA phosphorylation and subsequent Akt/moesin phosphorylation was suppressed in the CLC-4 knock down cells."
24036377
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"Interestingly, although NGF and NT3 similarly stimulated TrkA phosphorylation at pH 7, NGF but not NT3 promoted phosphorylation of TrkA at pH 6 and below ( xref )."
21816277
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"Before attempting to investigate retrograde tyrosine phosphorylations in compartmented cultures, the NGF-induced trk phosphorylation was characterized in mass cultures of rat sympathetic neurons."
9230082
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"Instead the mimicking peptides NGF(1–14) and dNGF(1–15) induced exclusively TrkA phosphorylation, an effect strongly influenced by copper ions."
31638089
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"Exogenous NGF induced greater phosphorylation of TrkA and AKT."
21419569
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"To assess the time course of NGF-induced trk phosphorylation, cultures grown in 200 ng/ml NGF were given NGF-free medium for 2 h and then given 200 ng/ml NGF for various times. trk tyrosine phosphorylation was detected within 5 min and persisted for at least 24 h (Fig. xref b ), consistent with a role for trk autophosphorylation in mediating long-term, not just transient, signals."
9230082
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"Both NGF and DHEA strongly increased phosphorylation of TrkA as early as 10 min, an effect which was also maintained at 20 min (XREF_FIG)."
21541365
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"Both NGF and DHEA strongly induced the phosphorylation of TrkA in naive PC12 cells, effects which were diminished in siRNA TrkA transfected PC12 cells (XREF_FIG)."
21541365
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"At a concentration of 10 ng/ml, NGF induced greater phosphorylation of TrkA (p-TrkA) and AKT in TrkA and p75 cells than in TrkA alone (XREF_FIG)."
21419569
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"In addition, monoamine-activated alpha1M enhanced the NGF-promoted TrkA phosphorylation and up-regulated the expression of NGF-inducible immediate-early genes (c-jun and NGFI-A) and delayed-response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect."
10617108
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"In placental total lysates no differences were found in NGF, TrkA, phosphorylated TrkA (both pY490 and pY496), Raf-1, RhoA, ROCK1 and ROCK2 protein levels between SSRI treated women, depressed women and healthy controls (XREF_TABLE)."
25611484
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"NGF treatment induced equal phosphorylation of TrkA and AKT in TrkA and TrkA and p75 cells at higher concentrations (100 ng/ml)."
21419569
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"It has been known that NGF induced autophosphorylation of Y-670, Y-674, and Y-675 is essential for TrkA activity and causes trans-phosphorylation of TrkA at Y-490 and Y-785, resulting in the activation of NGF mediated TrkA signaling XREF_BIBR."
23319303
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"Under identical conditions, a closely related neurotrophin NGF readily induced phosphorylation of its receptor TrkA in brain microslices prepared from mature brain tissues, suggesting that the dramatic reduction in the responsiveness of TrkB to BDNF in a mature tissue is not related to a reduced penetrance of the neurotrophin or to any general unsuitability of the assay for adult brain tissues."
22396798
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"We have developed custom ELISA assays to measure NGF-induced phosphorylation of TrkA specific for rodent and human receptors."
28279735
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"In this report, we show that methylamine activated PZP (MA-PZP), like MA-alpha (2) M, inhibits in a dose dependent way the NGF promoted neurite extension and TrkA phosphorylation in PC12 cells."
12237864
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"Interestingly, although NGF and NT3 similarly stimulated TrkA phosphorylation at pH 7, NGF but not NT3 promoted phosphorylation of TrkA at pH 6 and below (XREF_FIG)."
21816277
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"However in HEK293 cells transfected with TrkA receptors, PTX was unable to affect the induction of TrkA phosphorylation by NGF or DHEA (XREF_SUPPLEMENTARY)."
21541365
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"We found that inhibition of CD44 and p115RhoGEF either through siRNA or the ROCK1 specific inhibitor Y-27632 totally abolished NGF-induced invasion Interestingly, blocking CD44 affected neither NGF-induced TrkA phosphorylation nor the canonical TrkA pathways that signal through Akt and Src ( xref )."
25840418
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"TrkA/CD44 association is independent of NGF-induced TrkA phosphorylation."
25840418
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"PACAP38 provoked an increase in basal and NGF stimulated phosphorylation of trkA."
10542132
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"Our findings that blocking CD44 abolished NGF-induced cell invasion but did not affect NGF-induced TrkA tyrosine kinase phosphorylation, prompted us to evaluate whether the activation state of TrkA could affect the TrkA/CD44 association at the plasma membrane."
25840418
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"NGF induces phosphorylation of its high-affinity receptor tropomyosin-related kinase A (TrkA), leading to the activation of the MAPK/ERK signaling pathway, which promotes CRC metastasis [62]."
37610689
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"Therefore, when considering possible mechanisms, it would be premature to rule out Ca 2+ as playing a role in propagating the NGF-induced retrograde phosphorylation of trk."
9230082
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"In HEK TrkPC1 and HEK Trk0 cells such an effect takes place in presence of a transient antagonistic role on NGF-induced TrkA phosphorylation detected at the 100 ng/ml concentration, indicating that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15748886
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"Stimulation of NGF induces the phosphorylation of TrkA receptors, which is followed by TrkA internalization and trafficking through the endocytic pathway [XREF_BIBR]."
26588713
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"We found that the levels of TrkA phosphorylation induced by NGF stimulation were reduced in AS transfectants compared to CMV control cells at 3, 5 and 24 hours after NGF treatment."
26588713
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"NGF induces oligomerization and transphosphorylation of TrkA."
28494216
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"Therefore, we investigated whether these signaling pathways are activated after NGF stimulation in SK-N-MC cells.Exposure of serum-starved SK-N-MC cells to NGF induced the phosphorylation of TrkA, whi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14988025
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"K252a was found to inhibit NGF-induced TrkA tyrosine phosphorylation, and it binds TrkA with high affinity ( K D = 3 nM); however, it also broadly interferes with other tyrosine and serine/threonine p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23103525
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"NGF increased TrkA phosphorylation in hippocampal neurons and provided protection that required phosphoinositol-3-phosphate (PI3)-kinase activity and Akt phosphorylation, whereas the mitogen activated protein kinases (MAPK), extracellular regulated kinases (Erk) 1/2, were not involved."
12453482
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"We first tested the ability of AZ64 to inhibit Trk phosphorylation induced by exogenous NGF or BDNF in the SY5Y-Trk-transfected neuroblastoma lines."
22623209
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"We show that inhibiting endocytosis or furin activity reduced TrkA activation induced by proNGF but not that induced by mature NGF and that proNGF123, a mutant form of NGF lacking dibasic cleavage sites in the prodomain, does not induce TrkA phosphorylation in PC12 cells."
18299325
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"These studies are similar to recent findings in peripheral sensory neurons where increased surface expression of TRPV1 channels in DRG neurons is induced via NGF mediated activation of TrkA and subsequent channel phosphorylation by Src kinase."
19748836
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"Specifically, NGF enhanced TrkA phosphorylation, PI3K activity, and Akt phosphorylation."
17666398
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"Therefore, we conclude mat the presence of Trk b, but not p751 ' < GFR, Trk a, or Trk c, on transformed B lympho- cytes and the phosphorylation of Trk b on these cells by physiological concentrations [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8632056
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"Interestingly, NGF was more efficient in the induction of Trk and Akt phosphorylation, thus, NGF significantly increased Trk phosphorylation, in comparison with trimmed ganglia, from 15 +/- 1 to 40 +/- 1% of neurons (p < 0.0001), whereas Akt phosphorylation increased from 10 +/- 1 to 41 +/- 1% of neurons (p < 0.0001)."
28744222
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"CTB treatment (1 micrograms/ml) enhanced NGF induced neurite outgrowth from PC12 cells, NGF induced activation of ribosomal protein S6 kinase, and NGF induced stimulation of trk phosphorylation."
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"Immunoprecipitation of lysates from naive and NGF-treated PC12 cells (100 ng/ml NGF for 5 min, with or without 50 μM BB), followed by SDS-PAGE, Western blotting and immunoreaction with anti-phosphotyr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10727719
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"Although pre-treatment of PC12 cells with ceramide for short periods of time as those used in Salina's studies might not have affected TrkA, it has been demonstrated that longer ceramide exposure dram[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17084809
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"16 From this library, acetaldehyde adduct 5a (R1 = methyl, R2 = H) was found to be a potent TrkA inhibitor (IC 50 = 33 nM) with a cell score of 4 for inhibition of NGF-stimulated Trk phosphorylation."
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