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NGF phosphorylates NTRK1. 143 / 144
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"TrkA is a marker of the cholinergic cell bodies in the septum and NGF infusion in vivo elicits TrkA phosphorylation, increases the size of cholinergic neurons and stimulates Chat expression."
20554873
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"During early postnatal development in rats, these cholinergic neurons express TrkA mRNA ( Ringstedt et al., 1993 ) and moderate levels of p75 NGFR ( Koh and Loy, 1989 ), and show NGF-induced TrkA pho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9704891
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"NGF-induced TrkA tyrosine phosphorylation, detected using an anti-P-TrkA Y794 antibody, was diminished by adenovirus-mediated over-expression of PTP1B WT ( xref )."
28919207
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"Moreover, NGF-induced phosphorylation of TrkA and ERK was also attenuated by the transfection with a dominant-negative src construct."
14988025
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"Pretreatment with SIN-1 also resulted in a decrease in the NGF-induced phosphorylation of TrkA protein."
11169611
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"3.3 NGF salvages serum deprived NPM-ALK + T-cell lymphoma cells and induces the phosphorylation of TrkA in these cells."
28557340
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"This antibody completely blocks NGF-induced TrkA phosphorylation in septal cultures (data not shown)."
20554873
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"PACAP38 provoked an increase in basal and NGF stimulated phosphorylation of trkA."
10542132
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"The treatment of cells with NGF triggered TRKA phosphorylation at Y674 and Y675 (Figure xref ), and induced potent neurite outgrowth confirmed by immunocytochemistry for a marker of young neurons, a class III ß-tubulin (TuJ1) [ xref ] (Figure xref )."
29312610
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"NGF-induced TrkA phosphorylation and activation of MAPK are also reduced by nitrative stress caused by peroxynitrite in PC12 cells [ xref ]."
34440751
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"At a concentration of 10 ng/ml, NGF induced greater phosphorylation of TrkA (p-TrkA) and AKT in TrkA and p75 cells than in TrkA alone (XREF_FIG)."
21419569
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"Our data provide evidence that orthovanadate could mimic NGF mediated phosphorylation of the TrkA receptor.To investigate whether NGF was required for the neuroprotective effect of orthovanadate we em[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15209419
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"We found that the levels of TrkA phosphorylation induced by NGF stimulation were reduced in AS transfectants compared to CMV control cells at 3, 5 and 24 hours after NGF treatment."
26588713
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"NGF induced the phosphorylation of TrkA, and it also enhanced the level of activated Akt and vascular endothelial growth factor (VEGF) mRNA."
23337506
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"In placental total lysates no differences were found in NGF, TrkA, phosphorylated TrkA (both pY490 and pY496), Raf-1, RhoA, ROCK1 and ROCK2 protein levels between SSRI treated women, depressed women and healthy controls (XREF_TABLE)."
25611484
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"Exogenously added NGF induced rapid phosphorylation of TrkA tyrosine kinase."
14706643
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"To assess the time course of NGF-induced trk phosphorylation, cultures grown in 200 ng/ml NGF were given NGF-free medium for 2 h and then given 200 ng/ml NGF for various times. trk tyrosine phosphorylation was detected within 5 min and persisted for at least 24 h (Fig. xref b ), consistent with a role for trk autophosphorylation in mediating long-term, not just transient, signals."
9230082
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"Interestingly, although NGF and NT3 similarly stimulated TrkA phosphorylation at pH 7, NGF but not NT3 promoted phosphorylation of TrkA at pH 6 and below (XREF_FIG)."
21816277
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"Neurite outgrowth in PC12 cells depends on NGF mediated binding and activation and phosphorylation of the TrkA receptor and downstream signaling events leading to new gene expression."
21849477
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"Therefore, when considering possible mechanisms, it would be premature to rule out Ca 2+ as playing a role in propagating the NGF-induced retrograde phosphorylation of trk."
9230082
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"Additionally, NPPB and SITS, another chloride channel blocker, suppressed NGF-induced TrkA phosphorylation and subsequent PI3K/Akt phosphorylation and Rac1 activation in PC12 cells."
20144672
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"Under identical conditions, a closely related neurotrophin NGF readily induced phosphorylation of its receptor TrkA in brain microslices prepared from mature brain tissues, suggesting that the dramatic reduction in the responsiveness of TrkB to BDNF in a mature tissue is not related to a reduced penetrance of the neurotrophin or to any general unsuitability of the assay for adult brain tissues."
22396798
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"NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro."
9671662
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"We found that inhibition of CD44 and p115RhoGEF either through siRNA or the ROCK1 specific inhibitor Y-27632 totally abolished NGF-induced invasion Interestingly, blocking CD44 affected neither NGF-induced TrkA phosphorylation nor the canonical TrkA pathways that signal through Akt and Src ( xref )."
25840418
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"Mutations in the TrkA gene cause a related disorder, HSAN IV, which produces a phenotype similar to HSAN V. xref These TrkA gene mutations result in defective binding of NGF to TrkA and, as a result, the inhibition of NGF-induced TrkA phosphorylation and downstream signaling cascades. xref "
32547184
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"Moreover, 5 min of NGF stimulation after IFN-gamma treatment caused the phosphorylation of TrkA protein and downstream proteins."
10842245
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"Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF."
1706478
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"Specifically, NGF enhanced TrkA phosphorylation, PI3K activity, and Akt phosphorylation."
17666398
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"As expected, NGF promoted TrkA phosphorylation [ xref ]."
25611061
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"NGF stimulates phosphorylation of the TRK protein in neural cell lines and in embryonic dorsal root ganglia. "
1850821
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"Both NGF and DHEA strongly induced the phosphorylation of TrkA in naive PC12 cells, effects which were diminished in siRNA TrkA transfected PC12 cells (XREF_FIG)."
21541365
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"Each mutation was systematically analyzed for TRKA glycosylation states, intracellular and cell membrane expression patterns, nerve growth factor stimulated TRKA autophosphorylation, TRKA-Y496 phosphorylation, PLCgamma activity, and neurite outgrowth."
27676246
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"NGF increased TrkA phosphorylation in hippocampal neurons and provided protection that required phosphoinositol-3-phosphate (PI3)-kinase activity and Akt phosphorylation, whereas the mitogen activated protein kinases (MAPK), extracellular regulated kinases (Erk) 1/2, were not involved."
12453482
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"NGF-induced NTRK1 activation causes ABL1 (c-Abelson kinase 1 or c-Abl)–mediated phosphorylation of the adaptor protein Crk at Tyr 222 , resulting in the dissociation of paxillin and c-Abl from Crk ( xref ), which is critical for NGF-induced neurite out-growth ( xref )."
22126966
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"We found that in neurons treated with monensin, higher concentrations of NGF were required to elicit similar levels of phosphorylation of TrkA and the downstream signaling effectors Akt and Erk1/2 seen in control neurons (XREF_FIG)."
19759314
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"In this study we found that NEAP/DUSP26 expression decreased TrkA and FGFR1 phosphorylation induced by NGF and, conversely, knockdown of NEAP enhanced TrkA and FGFR1 activation."
28701747
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"Interestingly, although NGF and NT3 similarly stimulated TrkA phosphorylation at pH 7, NGF but not NT3 promoted phosphorylation of TrkA at pH 6 and below ( xref )."
21816277
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"Albanese's group xref , xref , xref reported compound 12 (milciclib, PHA-848125) as a dual inhibitor of cyclin-dependent kinase (CDK-2)/TRKA ( xref ), which can effectively inhibit NGF-induced TRKA phosphorylation and downstream signaling in DU-145 human prostate cancer cells with IC 50 values of 53 and 45 nmol/L, respectively."
33643817
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"Antisense knockdown of RabGEF1 expression reduces NGF-induced TrkA phosphorylation but not its internalization."
26588713
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"Tyrphostin AG1478, the EGFR inhibitor, inhibits fMLP and NGF-associated ROS production, fMLP-associated CD11b upregulation and NGF-induced TrkA phosphorylation; K252a, the NGF receptor inhibitor, inhibits fMLP or EGF-associated ROS production, CD11b expression and EGF-induced EGFR phosphorylation; cyclosporine H, the FPR inhibitor inhibits EGF or NGF-associated ROS production, EGF-associated CD11b upregulation and prevents EGFR and TrkA phosphorylation by their respective ligand EGF and NGF."
20566383
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"We have developed custom ELISA assays to measure NGF-induced phosphorylation of TrkA specific for rodent and human receptors."
28279735
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"NGF-induced tyrosine phosphorylation of phospholipase Cgamma, TrkA, and Shc was unaltered in the Shb-overexpressing cells, whereas that of Shb was greatly enhanced in these cells compared with control PC12-neo cells."
9751119
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"Stimulation of NGF induces the phosphorylation of TrkA receptors, which is followed by TrkA internalization and trafficking through the endocytic pathway [XREF_BIBR]."
26588713
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"The development of TrkA function in the neostriatum appears to start somewhere between P0 and P7, since NGF can induce TrkA tyrosine kinase phosphorylation in neostriatal tissue in vitro from P7 but n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9704891
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"Specifically, NGF enhanced TrkA phosphorylation, PI3K activity, and Akt phosphorylation."
17666398
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"CTB treatment (1 micrograms/ml) enhanced NGF-induced neurite outgrowth from PC12 cells, NGF-induced activation of ribosomal protein S6 kinase, and NGF-induced stimulation of trk phosphorylation."
8455041
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"Our findings that blocking CD44 abolished NGF-induced cell invasion but did not affect NGF-induced TrkA tyrosine kinase phosphorylation, prompted us to evaluate whether the activation state of TrkA could affect the TrkA/CD44 association at the plasma membrane."
25840418
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"Surprisingly, the antiestrogen drug tamoxifen (TAM) inhibited NGF induced MCF-7 cell proliferation and trkA (NGFR) phosphorylation in a concentration related fashion."
11306479
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"In particular, the inhibition of EGFR prevented the ligand dependent responses mediated by the other two receptors, while the inhibition of FPR abolished the EGFR and TrkA phosphorylation induced by EGF and NGF, respectively."
22251451
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"Because inhibition of endogenous SHP-1 stimulates the NGF independent phosphorylation of TrkA, SHP-1 can regulate the basal, nonliganded activity of TrkA."
14662744
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"MS-430 also prolonged the NGF-induced phosphorylation of MAPK, but the phosphorylation of TrkA induced by NGF was not affected by MS-430."
9538224
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"Given that many NGF effects are mediated by activation of its receptor TrkA and downstream signaling kinases such as MAPKs and PI3K/AKT, we examined whether L5 weakens NGF-induced TrkA phosphorylation and resultant activation of MAPKs (ERK, JNK, and p38) and Akt in PC12 cultures."
28800073
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"In compartmentalized cultures, NGF treatment of distal axons (100ngperml, 8h) resulted in the robust phosphorylation of TrkA receptors and of canonical signalling effectors, Erk1/2 and Akt, locally within distal axons in both RCAN1- and GFP expressing neurons."
26658127
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"Overall, our data provide strong evidence that orthovanadate could mimic NGF mediated phosphorylation of the TrkA receptor by preventing the dephosphorylation of the TrkA receptor in rat hippocampal n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15209419
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"Under identical conditions, a closely related neurotrophin NGF readily induced phosphorylation of its receptor TrkA in brain microslices prepared from mature brain tissues, suggesting that the dramatic reduction in the responsiveness of TrkB to BDNF in a mature tissue is not related to a reduced penetrance of the neurotrophin or to any general unsuitability of the assay for adult brain tissues."
22396798
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"TrkA/CD44 association is independent of NGF-induced TrkA phosphorylation."
25840418
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"Also, the NGF-induced TrkA phosphorylation and subsequent Akt/moesin phosphorylation was suppressed in the CLC-4 knock down cells."
24036377
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"In particular, the inhibition of EGFR prevented the ligand-dependent responses mediated by the other two receptors, while the inhibition of FPR abolished the EGFR and TrkA phosphorylation induced by EGF and NGF, respectively."
22251451
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"NGF caused dose dependent proliferation of HASMC and induced TrkA phosphorylation, both abolished by the tyrosine kinase inhibitor K252a."
16091303
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"In this report, we demonstrate for the first time that NGF induces TrkA and CD44 interaction independent of TrkA phosphorylation in cancer cells."
25840418
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"NGF stimulation of sympathetic axons resulted in a striking increase in phosphorylation of TrkA receptors derived from the soma surface (XREF_FIG)."
28919207
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"NGF-induced phosphorylation of TrkA and mitogen-activated protein kinase was significantly diminished in the necdin-null sensory ganglia."
16049186
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"We show that inhibiting endocytosis or furin activity reduced TrkA activation induced by proNGF but not that induced by mature NGF and that proNGF123, a mutant form of NGF lacking dibasic cleavage sites in the prodomain, does not induce TrkA phosphorylation in PC12 cells."
18299325
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"The lack of palmitoylation had no effect on the ability of p75 to enhance the short-term NGF-induced tyrosine phosphorylation of TrkA over a wide range of NGF concentrations."
11020215
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"Inhibiting TrkA by MNAC13 effectively suppressed the increased phosphorylation of TrkA induced by NGF and the NGF stimulated growth in ISC derived organoids."
30988299
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"As expected, NGF and BDNF both promoted Akt and Erk phosphorylation in TrkA and TrkB-expressing MG87 fibroblasts, respectively (Figures xref )."
28680400
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"NGF caused a robust increase of TrkA phosphorylation after 10 min, whereas the TrkA phosphorylation by epinephrine was considerably delayed compared with NGF treatment and required at least 60 min."
17215105
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"There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [ xref ]."
20482876
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"In this report, we show that methylamine activated PZP (MA-PZP), like MA-alpha (2) M, inhibits in a dose dependent way the NGF promoted neurite extension and TrkA phosphorylation in PC12 cells."
12237864
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"Analogous to the findings with RCAN1 overexpression, axonal application of calcineurin inhibitors had no effect on NGF dependent phosphorylation of TrkA, Erk1/2 and Akt locally within distal axons."
26658127
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"NGF led to the phosphorylation of TrkA, mitogen activated protein kinase (MAPK), and p38 MAPK but not stress activated protein kinase and c-Jun NH2-terminal kinase in PANC-1 and MIA-PaCa-2 cells."
11205897
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"In RNCMs, recombinant NGF induced trkA phosphorylation, followed by Ser473 phosphorylation and nuclear translocation of phospho-protein kinase B (Akt)."
17992191
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"Depletion of cholesterol resulted in an increased basal level of MAPK activity, but inhibited the activation of MAPK by TrkA, although not affecting NGF-induced phosphorylation of TrkA."
18949068
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"Then, we set to examine whether NGF induces the phosphorylation of TrkA in NPM‐ALK + T‐cell lymphoma."
28557340
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"In HEK TrkPC1 and HEK Trk0 cells such an effect takes place in presence of a transient antagonistic role on NGF-induced TrkA phosphorylation detected at the 100 ng/ml concentration, indicating that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15748886
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"Even when caffeate esters were applied together with NGF, they did not increase TrkA phosphorylation induced by NGF."
30562988
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"NGF treatment produced phosphorylation of TrkA in choroidal and retinal endothelial cells."
14614965
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"Both NGF and NT-3 induce the rapid phosphorylation of gp140trk receptors and the transient expression of c-Fos proteins."
1649007
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"We investigated whether this compound improved NGF induced tyrosine phosphorylation of the Y490 domain of TrkA and conserved the expression of an early gene (c-fos) in human NB cell lines (IMR-32 and NB-39)."
17409494
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"Furthermore, clivorine reduced the NGF induced the phosphorylations of TrkA, protein kinase B and cAMP response element binding protein in cultured PC12 cells."
27387401
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"NTRK1, a neurotrophic tyrosine kinase receptor, is phosphorylated in response to NGF [6,7] and mutations in NTRK1 have been associated with HSAN IV [8] ."
16373086
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"NGF at low level induced the phosphorylations of TrkA (~ 140 kDA), Erk1/2 (~ 44/42kDa), and Akt (~ 60kDa) within 5min (XREF_FIG)."
22761636
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"At a concentration of 10 ng/ml, NGF induced greater phosphorylation of TrkA (p-TrkA) and AKT in TrkA/p75 cells than in TrkA alone ( xref )."
21419569
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"Interestingly, NGF was more efficient in the induction of Trk and Akt phosphorylation, thus, NGF significantly increased Trk phosphorylation, in comparison with trimmed ganglia, from 15 +/- 1 to 40 +/- 1% of neurons (p < 0.0001), whereas Akt phosphorylation increased from 10 +/- 1 to 41 +/- 1% of neurons (p < 0.0001)."
28744222
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"As previously reported, while exposure to K-252a inhibited NGF-induced p-TrkA levels ( xref , xref ), co-treatment with 17-DMAG and K-252a produced further decline in the NGF-induced phosphorylation of TrkA ( xref )."
20663926
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"NGF can cause phosphorylation of TrkA."
16181609
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"NGF stimulates phosphorylation of the TRK protein in neural cell lines and in embryonic dorsal root ganglia. "
11205897
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"We show for the first time that CA8 overexpression inhibited NGF-stimulated ITPR1 and TrkA phosphorylation, and ITPR1-mediated calcium release in vitro."
29789638
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"However, and surprisingly, we found that TrkA phosphorylation induced by NGF was absent in APP YG/YG mice (XREF_FIG, bottom panel)."
21849536
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"Exogenous NGF induced greater phosphorylation of TrkA and AKT."
21419569
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"NGF treatment induced equal phosphorylation of TrkA and AKT in TrkA and TrkA and p75 cells at higher concentrations (100 ng/ml)."
21419569
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"In addition, monoamine-activated alpha1M enhanced the NGF-promoted TrkA phosphorylation and up-regulated the expression of NGF-inducible immediate-early genes (c-jun and NGFI-A) and delayed-response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect."
10617108
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"In this reversed experiment, both NGF-induced TrkA and FGFR1 Tyr phosphorylation (normalized by receptor levels) were elevated in PC12-shNEAP cells in comparison to those in PC12-pSuper control cells (Fig.  xref )."
28701747
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"In addition, GM1 potentiated the NGF mediated activation of tyrosine phosphorylation of trkA."
7790879
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"In addition, monoamine activated alpha1M enhanced the NGF promoted TrkA phosphorylation and up-regulated the expression of NGF inducible immediate-early genes (c-jun and NGFI-A) and delayed response genes (SCG10 and transin) in PC12 cells; normal alpha1M, in contrast, produced little or no effect."
10617108
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"Then, we set to examine whether NGF induces the phosphorylation of TrkA in NPM-ALK + T-cell lymphoma."
28557340
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"NTRK1, a neurotrophic tyrosine kinase receptor, is phosphorylated in response to NGF [6,7] ."
18077166
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"Immunoprecipitation of lysates from naive and NGF-treated PC12 cells (100 ng/ml NGF for 5 min, with or without 50 μM BB), followed by SDS-PAGE, Western blotting and immunoreaction with anti-phosphotyr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10727719
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"In these B cells, NGF failed to induce Trk A phosphorylation, cytoskeleton assembly, or MAP kinase activation."
15163901
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"NGF causes the phosphorylation of TrkA on many sites, including one that allows it to recruit and activate PLCgamma."
27503831
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"However in HEK293 cells transfected with TrkA receptors, PTX was unable to affect the induction of TrkA phosphorylation by NGF or DHEA (XREF_SUPPLEMENTARY)."
21541365
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"Each mutation was systematically analyzed for TRKA glycosylation states, intracellular and cell membrane expression patterns, nerve growth factor stimulated TRKA autophosphorylation, TRKA-Y496 phosphorylation, PLCγ activity, and neurite outgrowth."
27676246
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"Rab7 CMT2B mutants expressing PC12 cells show differential TrkA phosphorylation following NGF stimulation."
21151572
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"Later, linear cell-penetrating peptides, synthesised as HIV Tat fusions, were shown to inhibit NGF-stimulated TrkA phosphorylation and to suppress NGF-induced TRPV1 expression in PC12 cells xref ."
30700786
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"The developmentally reduced ability of BDNF to induce TrkB phosphorylation in the mouse brain microslices is probably not due to reduced penetrance of BDNF into mature brain tissue since a highly related neurotrophin, NGF (nerve growth factor), readily induced TrkA phosphorylation (Y674/5) in hippocampal microslices obtained from P24 mice (XREF_FIG)."
22396798
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"Immunoblotting analyses with a phospho specific antibody revealed that NGF increased TrkA phosphorylation at the PLC-gamma interaction site (Y794), as compared to untreated control cultures, or cultures treated with NT-3 (XREF_FIG)."
21689596
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"Compounds 1 and 3 Enhanced NGF-Induced TrkA and Erk1/2 Phosphorylation in PC12 Cells."
28758954
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"Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells."
14988025
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"In this study we found that NEAP and DUSP26 expression decreased TrkA and FGFR1 phosphorylation induced by NGF and, conversely, knockdown of NEAP enhanced TrkA and FGFR1 activation."
28701747
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"The results of western blot analysis clearly show that NGF stimulated TrkA phosphorylation on several tyrosine sites, including tyrosine 490, 674/675, and 785 (Fig.  xref )."
31694615
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"Both NGF and DHEA strongly increased phosphorylation of TrkA as early as 10 min, an effect which was also maintained at 20 min (XREF_FIG)."
21541365
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"These studies are similar to recent findings in peripheral sensory neurons where increased surface expression of TRPV1 channels in DRG neurons is induced via NGF mediated activation of TrkA and subsequent channel phosphorylation by Src kinase."
19748836
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"But the time window of TrkA phosphorylation induced by CB-NGF and NGF was different."
18585441
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"At the molecular level, NS 1231 enhanced NGF induced signalling events, such as TrkA phosphorylation at the Shc binding site Tyr490 as well as ERK activation in PC12 cells."
12067229
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"Although P28L strongly decreased NGF-induced phosphorylation of TrkA and the phosphorylation of the downstream kinase Akt (without affecting the phosphorylation of ERK1/2), the neighboring R26Q mutati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20472890
sparser
"We show for the first time that CA8 overexpression inhibited NGF-stimulated ITPR1 and TrkA phosphorylation, and ITPR1-mediated calcium release in vitro ."
29789638
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"In PC12 cells, a depletion of membrane cholesterol decreased the magnitude and duration of NGF stimulated p42/44 MAPK as well as the phosphorylation of TrkA."
22740150
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"Preincubation with SgG2 did not affect NGF dependent TrkA or ERK phosphorylation ( xref ) and, in agreement with xref , changes on signaling were detected only when SgG2 was added together with NGF."
25611061
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"In this report, we provide preliminary evidence that overexpression of the human wildtype ortholog of Car8 (CA8 WT ), but not the reported CA8 S100P loss-of-function mutation (CA8 MT ); inhibits nerve growth factor (NGF)-induced phosphorylation of ITPR1, TrkA (NGF high affinity receptor); and ITPR1-mediated cytoplasmic free calcium release in vitro."
29789638
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"CTB treatment (1 micrograms/ml) enhanced NGF induced neurite outgrowth from PC12 cells, NGF induced activation of ribosomal protein S6 kinase, and NGF induced stimulation of trk phosphorylation."
8455041
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"As previously described, NGF induced an increase in TrkA and P38 phosphorylation [19] (Fig. 2a)."
27576911
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"Interestingly, NGF was more efficient in the induction of Trk and Akt phosphorylation, thus, NGF significantly increased Trk phosphorylation, in comparison with trimmed ganglia, from 15 ± 1 to 40 ± 1% of neurons ( p < 0.0001), whereas Akt phosphorylation increased from 10 ± 1 to 41 ± 1% of neurons ( p < 0.0001)."
28744222
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"It has been known that NGF induced autophosphorylation of Y-670, Y-674, and Y-675 is essential for TrkA activity and causes trans-phosphorylation of TrkA at Y-490 and Y-785, resulting in the activation of NGF mediated TrkA signaling XREF_BIBR."
23319303
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"In contrast, NGF and NT-3-mediated phosphorylation of TrkA and TrkC, respectively, do not require cAMP."
25064589
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"Our data showed that cavtratin suppresses the NGF-induced phosphorylation of TrkA as well as the activation of MAPK in porcine oligodendrocytes significantly."
21523467
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"NGF-dependent trkA phosphorylation was significantly enhanced by the presence of the peptide, whereas high-affinity binding of 125I-NGF, both NGF receptors mRNA and protein expression, and trkA dimer/monomer ratios were not influenced."
9603197
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"NT-3 [XREF_BIBR - XREF_BIBR], but not NGF [XREF_BIBR, XREF_BIBR], stimulates Trk phosphorylation and downstream signaling in rat primary cortical neurons."
26223799
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"Sixth, LPA and/or NGF stimulated the translocation of tyrosine phosphorylated Trk A receptor and LPA (1) receptor to the nucleus."
14607283
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"Similarly to what was observed for PC12 cells, even when caffeate esters were added in addition to NGF, they did not increase NGF-induced TrkA phosphorylation."
30562988
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"NGF can cause phosphorylation of TrkA."
16181609
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"Approximately equivalent levels of soluble versus immobilized ligand were applied based on our previous assessments of TrkA phosphorylation by the NGF microparticles."
17785519
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"Application of nerve growth factor (NGF) covalently cross linked to beads increased the phosphorylation of TrkA and Akt, but not of mitogen activated protein kinase, in cultured rat sympathetic neurons."
11799202
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"NGF (3 pM) induced TrkA receptor phosphorylation within 10 s; it reached a plateau at 30 s to 15 min and decreased after 30 min."
16091303
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"Indeed, MNAC13 effectively inhibited the NGF-induced phosphorylation of TrkA and Akt in 3T3 cells expressing TrkA, but did not suppress the phosphorylation of TrkB/C induced by BDNF and NT-3 in 3T3 cells expressing TrkB/C (Supplementary Fig.  xref )."
30988299
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"Before attempting to investigate retrograde tyrosine phosphorylations in compartmented cultures, the NGF-induced trk phosphorylation was characterized in mass cultures of rat sympathetic neurons."
9230082
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"We first tested the ability of AZ64 to inhibit Trk phosphorylation induced by exogenous NGF or BDNF in the SY5Y-Trk-transfected neuroblastoma lines."
22623209
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"Levels of TrkA receptor phosphorylation and downstream ERK activation induced by NGF were not influenced by GnT-VB expression."
16606368
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"NGF treatment caused a rapid phosphorylation of trkA (NGFR) in HUVECs, determining a parallel increase of phosphorylated ERK1/2."
12154004
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"Therefore, we conclude mat the presence of Trk b, but not p751 ' < GFR, Trk a, or Trk c, on transformed B lympho- cytes and the phosphorylation of Trk b on these cells by physiological concentrations [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8632056
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"To identify the cellular component (s) at which LPC acts to potentiate NGF-TrkA signal, we examined the phosphorylation of MEK and TrkA, and found that LPC enhances TrkA phosphorylation induced by NGF."
23772401
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"NGF salvages serum‐deprived NPM‐ALK + T‐cell lymphoma cells and induces the phosphorylation of TrkA in these cells."
28557340
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"Tyrphostin AG1478, the EGFR inhibitor, inhibits fMLP and NGF associated ROS production, fMLP associated CD11b upregulation and NGF induced TrkA phosphorylation; K252a, the NGF receptor inhibitor, inhibits fMLP or EGF associated ROS production, CD11b expression and EGF induced EGFR phosphorylation; cyclosporine H, the FPR inhibitor inhibits EGF or NGF associated ROS production, EGF associated CD11b upregulation and prevents EGFR and TrkA phosphorylation by their respective ligand EGF and NGF."
20566383
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"MS-430 also prolonged the NGF induced phosphorylation of MAPK, but the phosphorylation of TrkA induced by NGF was not affected by MS-430."
9538224