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NGF leads to the phosphorylation of NTRK1 on Y496. 17 / 17
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"These two signalling cascades are triggered by NGF-dependent phosphorylation of Y490 and Y751 residues of TrkA, which are also transphosphorylated upon FPR1 activation by N-fMLP ( xref )."
31871542
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"In the current study, our observations demonstrate that NGF promotes GC proliferation partly through phosphorylation of trkA at Tyr 490 ( Fig. S4 ) at low concentration (50 ng/ml) and suppresses GC la[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25737208
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"NGF-induced phosphorylation of TrkA at tyrosines 490 and 674/675, which are associated with TrkA recruitment of adapter proteins and kinase activity, respectively, was assessed by western blots probed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29325876
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"We investigated whether this compound improved NGF induced tyrosine phosphorylation of the Y490 domain of TrkA and conserved the expression of an early gene (c-fos) in human NB cell lines (IMR-32 and NB-39)."
17409494
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"NGF (50 ng/ml)-induced phosphorylation of TrkA at tyrosine 490, which is known to be the important site for the induction of MAPK and Akt signaling cascades [ xref ], was significantly enhanced by the addition of LPC (1 μM) ( xref C)."
23772401
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"Indeed, NGF induced the phosphorylation of TrkA at tyrosine residue 490, activating also the two TrkA down-stream pro-survival kinases ERK1/2 and AKT following an exposure of 15 min ( Fig. 2 C)."
27618740
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"Moreover, the upregulation of TrkA tyrosine-490 phosphorylation by NGF was not altered by either wortmannin or SP600125 4 h after NGF treatment, indicating a drug specificity of SP600125 and wortmannin."
27229480
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"NGF-induced phosphorylation of trkA at Y490 provides a recruitment site for binding of the adaptor protein Shc."
19126759
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"The Tyr-490 phosphorylation of TrkA stimulated by Ac-NGF(1–14) (50 μM) was inhibited by pre-treatment with BCS, but this effect was not restored by the presence of CuSO 4 and ZnSO 4 (Figure xref )."
28090201
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"However, the upregulation of TrkA tyrosine-490 phosphorylatin by NGF was significantly downregulated during the long-term inactivation of JNK caused by SP600125 treatment for 12 h, but not by wortmannin, suggesting a role of JNK in the maintenance of TrkA tyrosine-490 phosphorylation enhanced by NGF ( xref )."
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"The addition of a copper extracellular chelator, as bathocuproine disulfonate (BCS), partially inhibited Tyr-490 phosphorylation of TrkA induced by both NGF and mimicking peptides, whereas a supplement of exogenous copper ions partially restored it."
31638089
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"The addition of a copper extracellular chelator, as bathocuproine disulfonate (BCS), partially inhibited Tyr-490 phosphorylation of TrkA induced by both NGF and mimicking peptides, whereas a supplement of exogenous copper ions partially restored it.Differently, the reverse and scrambled peptides both in absence or presence of metal ions have no activity, confirming that the N-terminus sequence of protein is specifically involved in receptor interaction and metal binding specifically increase recognition process.The activation of TrkA by NGF or mimicking peptides triggered the signalling cascade of Akt and ERK."
31638089
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"Indeed, NGF induced the phosphorylation of TrkA at tyrosine residue 490, activating also the two TrkA down-stream pro-survival kinases ERK1/2 and AKT following an exposure of 15 min ( Fig. 2 C)."
27618740
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"SgG2 significantly increased NGF-dependent TrkA phosphorylation at tyrosine 490 (Tyr490) at 15 min, but not at 120 min post-incubation, when compared to control and M3 conditions ( xref )."
25611061
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"The presence of BCS totally blocked the Tyr 490 phosphorylation of TrkA stimulated by NGF (1-14) (50 muM) (P < 0.01); this effect was partially inhibited by the presence of metal ions (p < 0.05)."
28090201
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"At the molecular level, NS 1231 enhanced NGF induced signalling events, such as TrkA phosphorylation at the Shc binding site Tyr490 as well as ERK activation in PC12 cells."
12067229
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"Tyrosine residues at 490 and 670/674/674 of TrkA were rapidly phosphorylated after the NGF treatment ( Fig. 4 ); however, in the presence of the Cl − channel inhibitors, NPPB and SITS, the NGF-induced[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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