IndraLab

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SMAD3 phosphorylates SMAD3. 10 / 35
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"In agreement, pretreatment of MCF-7 cells with 17-beta-estradiol resulted in a reduced phosphorylation of Smad2 and Smad3 as well as a diminished Smad2 and Smad3 gene reporter activity in response to TGF-beta."
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"TGF-beta exerts its pro fibrotic effects through transcription factor signaling Smad3, and selective inhibition of Smad3 phosphorylation and inhibition of Smad3 interaction with Smad4 has been shown to reduce fibroblast activation to the myofibroblast phenotype and also reduce ECM synthetic activity of the cells."
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"In the present study, we observed that the TGF-beta1-induced phosphorylation of Smad2 and Smad3 and the TGF-beta1-induced increase in alpha-SMA production were partially dependent on Smad2 and Smad3 and were reversed by knockdown of both Smad2 and Smad3."
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"Trx overexpression further enhanced Smad3 phosphorylation and TD overexpression decreased Smad3 phosphorylation compared with the Ad-GFP control group after ox-LDL stimulation in HUVECs."
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"In vitro study showed that iTregs could suppress expression of IL-1beta and TNF-alpha, promote transcription of IL-10, and increase phosphorylation of mothers against decapentaplegic homolog 3 (SMAD3) in KCs."
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"Our data showed that both DN-Smad-2 and DN-Smad-3 significantly decreased Smad-2 and Smad-3 phosphorylation (Fig 2, A)."
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"Real time PCR was performed to look for gene expression of Fn and collagen IV and collagen I. TGFbeta1 induced the Smad1/5/8, Smad3 and p38 phosphorylation and CCN3 downregulated the TGFbeta1 induced Smad1/5/8 phosphorylation and did not affect Smad3 and p38 phosphorylation."
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"Second, although a Smad3 specific inhibitor, SIS3, potently inhibited TGFβ-induced Smad3 phosphorylation and subsequent activation of TGFβ/Smad3 dependent gene expression, it did not reverse the inhibitory effect of TGFβ on myogenesis."
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"HF showed a decrease in the TGF-β-induced accumulation of Smad3 and phosphorylated Smad3 (p-Smad3) at 300 nM."
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"In addition, knockdown of SMAD3 almost completely abolished TGF-β1-induced phosphorylation of SMAD3 but not SMAD2 ( Fig. 2 C)."
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Phosphorylated SMAD3 phosphorylates SMAD3. 4 / 4
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"Knocking down Rictor could not affect Smad3 phosphorylation induced by TGFbeta1 treatment, suggesting that the profibrotic role of Rictor in fibroblast is independent of Smad3 phosphorylation (XREF_SUPPLEMENTARY)."
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"As can be seen in XREF_FIG, PM2.5 enhanced the phosphorylation of Smad3 (P < 0.01), and 20% medicated serum inhibited the phosphorylation of Smad3 (XREF_FIG, P < 0.05)."
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"The transforming growth factor beta (TGF-beta) activates JNK, phosphorylates Smad3 to linker phosphorylated Smad3 (pSmad3L), resulting in liver tumorigenesis."
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"Phosphorylated forms (phospho-isoforms) in Smad-related pathways can transmit opposing signals: cytostatic C-terminally-phosphorylated Smad3 (pSmad3C) and carcinogenic linker-phosphorylated Smad3 (pSmad3L) signals."
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Modified SMAD3 leads to the phosphorylation of SMAD3. 3 / 3
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"Hence, both the high Smad3 level and the resistance of TbetaRI to forskolin may have contributed to the lack of the ability of forskolin to increase Smad3 phosphorylation and TGFbeta dependent gene expression in 3D cultured cells."
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"Hence, higher total levels of Smad3 not only led to higher Smad3 phosphorylation, but also to a higher transcriptional activity in response to TGFbeta."
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"Overexpression of Smad3 also increased TGFbeta dependent Smad3 phosphorylation and may therefore at least partially also be responsible for the higher phosphorylation status of Smad3 in TGFbeta treated 3D cultured cells."
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Unphosphorylated SMAD3 leads to the phosphorylation of SMAD3. 1 / 1
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"This result showed that FF might have reduced TGF‐β‐induced SMAD3 phosphorylation at a later time by dephosphorylating SMAD3 (Fig. 4A)."
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