IndraLab

Statements

Modified SMAD3 leads to the phosphorylation of SMAD3. 3 / 3
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"Hence, higher total levels of Smad3 not only led to higher Smad3 phosphorylation, but also to a higher transcriptional activity in response to TGFbeta."
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"Hence, both the high Smad3 level and the resistance of TbetaRI to forskolin may have contributed to the lack of the ability of forskolin to increase Smad3 phosphorylation and TGFbeta dependent gene expression in 3D cultured cells."
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"Overexpression of Smad3 also increased TGFbeta dependent Smad3 phosphorylation and may therefore at least partially also be responsible for the higher phosphorylation status of Smad3 in TGFbeta treated 3D cultured cells."
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