IndraLab

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Phosphorylated SMAD3 phosphorylates SMAD3. 4 / 4
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"Knocking down Rictor could not affect Smad3 phosphorylation induced by TGFbeta1 treatment, suggesting that the profibrotic role of Rictor in fibroblast is independent of Smad3 phosphorylation (XREF_SUPPLEMENTARY)."

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"As can be seen in XREF_FIG, PM2.5 enhanced the phosphorylation of Smad3 (P < 0.01), and 20% medicated serum inhibited the phosphorylation of Smad3 (XREF_FIG, P < 0.05)."

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"The transforming growth factor beta (TGF-beta) activates JNK, phosphorylates Smad3 to linker phosphorylated Smad3 (pSmad3L), resulting in liver tumorigenesis."

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"Phosphorylated forms (phospho-isoforms) in Smad-related pathways can transmit opposing signals: cytostatic C-terminally-phosphorylated Smad3 (pSmad3C) and carcinogenic linker-phosphorylated Smad3 (pSmad3L) signals."