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Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGF phosphorylates RAF1. 10 / 23
| 15 8
reach
"Consistent with this, we found that MEK inhibition inhibits CRAF NtA phosphorylation induced by EGF."
sparser
"In this report, we show that EGF phosphorylates and activates Raf-1 and B-Raf."
reach
"Activation ofRas by growth factors such as epidermal growth factor (EGF) phosphorylates C-Raf, causing its translocation from cytosol to the plasma membrane."
reach
"The result showed that melatonin significantly increased the phosphorylation of c-Raf, ERK1/2 and c-Myc and EGF significantly increased phosphorylation of c-Raf, ERK1/2 and c-Myc when compared with control."
sparser
"Defects in the EGFR signaling pathway cascade were found in all examined drug resistant sublines, including altered EGF-induced Shc, Raf-1, or mitogen-activated protein kinase phosphorylation."
reach
"Inhibition of Pak reduced the Ser (338) phosphorylation of c-Raf in response to both PDGF and EGF; however, in the case of EGF, the reduction in Ser (338) phosphorylation was not accompanied by a significant decrease in c-Raf activity."
sparser
"Down-regulation of protein kinase C did not affect the EGF-induced increase in RAF-1 phosphorylation."
reach
"Both estrogen and epidermal growth factor (EGF) induced phosphorylation of c-raf and ERK1/2 while stimulating the proliferation of SKBR3 cells [XREF_BIBR], and the two agents were more effective in combination."
reach
"EGF stimulated the phosphorylation of ERK and Raf-1 in both ADPKD and HKC cells, but had no effect on B-Raf."
sparser
"EGF-induced RAF-1 serine phosphorylation required the intrinsic tyrosine kinase activity of the EGF receptor but was independent of EGF receptor self-phosphorylation and of ligand-induced receptor internalization."
EGF leads to the phosphorylation of RAF1 on S338. 3 / 3
| 2 1
sparser
"While little or no effect was seen in cells treated with PLX4032, RGS treatment completely inhibited EGF-induced c-RAF Ser338 phosphorylation ( xref )."
reach
"On the other hand, co-expression of constitutively active PAK5 caused a very strong phosphorylation of cytoplasmic Raf-1 on serine 338 that was not further stimulated by addition of EGF (compare lanes 11 and 12), indicating that PAK5 could access Raf-1 in this fraction."
sparser
"Pharmacological inhibitors of PI 3-kinase also blocked both activation and Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF)."
EGF leads to the phosphorylation of RAF1 on serine. 3 / 3
| 3
reach
"Inhibition of Pak reduced the Ser (338) phosphorylation of c-Raf in response to both PDGF and EGF; however, in the case of EGF, the reduction in Ser (338) phosphorylation was not accompanied by a significant decrease in c-Raf activity."
reach
"In vivo EGF treatment rapidly stimulated phosphorylation of RAF-1 exclusively on serine residues."
reach
"EGF induced RAF-1 serine phosphorylation required the intrinsic tyrosine kinase activity of the EGF receptor but was independent of EGF receptor self phosphorylation and of ligand induced receptor internalization."
EGF leads to the phosphorylation of RAF1 on S301. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
EGF leads to the phosphorylation of RAF1 on S294. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"