IndraLab

Statements

EGF leads to the phosphorylation of RAF1. 10 / 35
| 19 16
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"In this report, we show that EGF phosphorylates and activates Raf-1 and B-Raf."
12644307
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"When overexpressed in cells, all variants were unable to negatively modulate EGF-promoted RAF1, MEK, and ERK phosphorylation, and time-course experiments in primary fibroblasts (p."
34626534
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"Both estrogen and epidermal growth factor (EGF) induced phosphorylation of c-raf and ERK1/2 while stimulating the proliferation of SKBR3 cells [XREF_BIBR], and the two agents were more effective in combination."
19308726
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"EGF stimulated the phosphorylation of ERK and Raf-1 in both ADPKD and HKC cells, but had no effect on B-Raf."
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"Moreover, the Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF) stimulation is impaired by an inhibitor of phosphoinositide 3-kinase (PI 3-kinase) 17 suggesting that PAK2 mediat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11316611
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"Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization."
1645717
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"Consistent with this, we found that MEK inhibition inhibits CRAF NtA phosphorylation induced by EGF."
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"The result showed that melatonin significantly increased the phosphorylation of c-Raf, ERK1/2 and c-Myc and EGF significantly increased phosphorylation of c-Raf, ERK1/2 and c-Myc when compared with control."
28275319
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"Defects in the EGFR signaling pathway cascade were found in all examined drug resistant sublines, including altered EGF-induced Shc, Raf-1, or mitogen-activated protein kinase phosphorylation."
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"Moreover, simultaneous knockdown of both PAK2 and PLA2G7 did not further attenuate EGF-stimulated S338-phosphorylation of RAF1 or phosphorylation of MEK and ERK (Figure 7F, right three lanes), which further support that PLA2G7 and PAK2 exist in the same signal pathway to regulate RAF1 activation."
35417664
EGF leads to the phosphorylation of RAF1 on S338. 5 / 5
| 3 2
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"While little or no effect was seen in cells treated with PLX4032, RGS treatment completely inhibited EGF-induced c-RAF Ser338 phosphorylation ( xref )."
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"Moreover, the Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF) stimulation is impaired by an inhibitor of phosphoinositide 3-kinase (PI 3-kinase) 17 suggesting that PAK2 mediat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11316611
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"Pharmacological inhibitors of PI 3-kinase also blocked both activation and Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF)."
10712905
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"On the other hand, co-expression of constitutively active PAK5 caused a very strong phosphorylation of cytoplasmic Raf-1 on serine 338 that was not further stimulated by addition of EGF (compare lanes 11 and 12), indicating that PAK5 could access Raf-1 in this fraction."
18465753
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"Moreover, simultaneous knockdown of both PAK2 and PLA2G7 did not further attenuate EGF-stimulated S338-phosphorylation of RAF1 or phosphorylation of MEK and ERK (Figure 7F, right three lanes), which further support that PLA2G7 and PAK2 exist in the same signal pathway to regulate RAF1 activation."
35417664
EGF leads to the phosphorylation of RAF1 on serine. 3 / 3
| 3
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"Inhibition of Pak reduced the Ser (338) phosphorylation of c-Raf in response to both PDGF and EGF; however, in the case of EGF, the reduction in Ser (338) phosphorylation was not accompanied by a significant decrease in c-Raf activity."
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"In vivo EGF treatment rapidly stimulated phosphorylation of RAF-1 exclusively on serine residues."
1645717
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"EGF induced RAF-1 serine phosphorylation required the intrinsic tyrosine kinase activity of the EGF receptor but was independent of EGF receptor self phosphorylation and of ligand induced receptor internalization."
1645717
EGF leads to the phosphorylation of RAF1 on S294. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983
EGF leads to the phosphorylation of RAF1 on S301. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
17081983